Navigation Links
Migraine sufferers more prone to hangover headache
Date:10/18/2009

(PHILADELPHIA) Migraine sufferers, beware. You may be more prone to an alcohol-induced headache after a night of drinking, according to researchers from the Jefferson Headache Center. The research will be presented at Neuroscience 2009, the Annual Meeting of the Society for Neuroscience, in Chicago.

Until now, studying the mechanism behind migraine and other forms of recurrent headaches has not been possible in an animal model, according to Michael Oshinsky, Ph.D., assistant professor of Neurology at Jefferson Medical College of Thomas Jefferson University, and a member of the Jefferson Headache Center team. In order to facilitate the study of migraine, Dr. Oshinsky developed a rat model in which headaches are induced by repeatedly stimulating, over weeks to months, the brain's dura mater with an inflammatory mixture.

Dr. Oshinsky and Christina Maxwell, a Ph.D. student in the Neuroscience program at the Jefferson College of Graduate Studies, used their rat model to study the effects of alcohol on rats who suffer recurrent migraines, compared to rats that do not get headaches. They analyzed four groups of rats: two groups received repeated dural simulation, followed by an oral ingestion of saline or alcohol (the equivalent of one to two shots of liquor). Two control groups received no inflammatory stimulation, and received the similar oral ingestion of saline or alcohol.

Migraine headaches are associated with hypersensitivity to light, sound and light touch on the head and face. The researchers measured the rats' sensitivity to touch around the eye, using von Frey monofilaments. They monitored the change in pain threshold of the face resulting from the repeated dural stimulation.

The rats that received dural stimulation followed by alcohol showed an initial analgesic effect within the first two hours after alcohol ingestion. However, four to six hours later, their pain sensitivity increased, indicating a more painful state. There were no changes in alcohol-induced sensitivity in the control groups.

"Our results suggest that dehydration or impurities in alcohol are not responsible for hangover headache," Dr. Oshinsky said. "Since these rats were sufficiently hydrated and the alcohol they received contained no impurities, the alcohol itself or a metabolite must be causing the hangover-like headache. These data confirm the clinical observation that people with migraine are more susceptible to alcohol-induced headaches."

Dr. Oshinsky and his laboratory are now also studying the mechanism for the induction of headache, and also the metabolites of alcohol that cause hangover.


'/>"/>

Contact: Emily Shafer
emily.shafer@jefferson.edu
215-955-6300
Thomas Jefferson University
Source:Eurekalert

Related medicine news :

1. Migraine Research Foundation Announces Winners of 2009 Research Grants
2. New Migraine Drug Shows Promise
3. Jefferson Headache Center study shows novel, orally inhaled migraine therapy effective
4. Latest Holiday Migraine Survey Results Published
5. While Some New Agents Will Achieve Strong Sales, the Migraine Drug Market Will Decline $1.3 Billion by 2018 as Generic Erosion Takes Toll on Top-Selling Brands
6. Plastic Surgery Technique Might Ease Migraines
7. Migraines Linked to Reduced Breast Cancer Risk
8. Link between migraines and reduced breast cancer risk confirmed in follow-up study
9. Migraine Frequency Tied to Stroke, Heart Attack Risk
10. Smoking more than 5 cigarettes a day provokes migraine attacks
11. Migraine With Aura May Lead to Brain Lesions
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... , ... June 26, 2016 , ... PawPaws brand ... new product that was developed to enhance the health of felines. The formula is ... The two main herbs in the PawPaws Cat Kidney Support Supplement Soft ...
(Date:6/25/2016)... ... June 25, 2016 , ... ... issues and applications at AcademyHealth’s Annual Research Meeting June 26-28, 2016, at the ... several important health care topics including advance care planning, healthcare costs and patient ...
(Date:6/25/2016)... Viejo, California (PRWEB) , ... June 25, 2016 , ... ... to fit their specific project," said Christina Austin - CEO of Pixel Film Studios. ... fully customizable and all within Final Cut Pro X . Simply select a ...
(Date:6/25/2016)... Oklahoma (PRWEB) , ... June 25, 2016 , ... ... both athletes and non-athletes recover from injury. Recently, he has implemented orthobiologic procedures ... Oklahoma City area —Johnson is one of the first doctors to perform the ...
(Date:6/24/2016)... Angeles, CA (PRWEB) , ... June 24, 2016 , ... ... surgery procedures that most people are unfamiliar with. The article goes on to state ... procedures, but also many of these less common operations such as calf and cheek ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... , June 23, 2016 ... CAPR ), a biotechnology company focused on ... today announced that patient enrollment in its ongoing ... Duchenne) has exceeded 50% of its 24-patient target. ... in the third quarter of 2016, and to ...
(Date:6/23/2016)... and INDIANAPOLIS , June 23, 2016 ... Lilly Diabetes Tomorrow,s Leaders Scholarship is any indication, the ... announced today online at www.diabetesscholars.org by the ... diabetes stand in the way of academic and community ... Foundation,s scholarship program since 2012, and continues to advocate ...
(Date:6/23/2016)... , June 23, 2016 The vast majority ... outpatient dialysis facility.  Treatments are usually 3 times a ... per visit, including travel time, equipment preparation and wait ... but especially grueling for patients who are elderly and ... skilled nursing and rehabilitation centers for some duration of ...
Breaking Medicine Technology: