Navigation Links
Migraine sufferers more prone to hangover headache
Date:10/18/2009

(PHILADELPHIA) Migraine sufferers, beware. You may be more prone to an alcohol-induced headache after a night of drinking, according to researchers from the Jefferson Headache Center. The research will be presented at Neuroscience 2009, the Annual Meeting of the Society for Neuroscience, in Chicago.

Until now, studying the mechanism behind migraine and other forms of recurrent headaches has not been possible in an animal model, according to Michael Oshinsky, Ph.D., assistant professor of Neurology at Jefferson Medical College of Thomas Jefferson University, and a member of the Jefferson Headache Center team. In order to facilitate the study of migraine, Dr. Oshinsky developed a rat model in which headaches are induced by repeatedly stimulating, over weeks to months, the brain's dura mater with an inflammatory mixture.

Dr. Oshinsky and Christina Maxwell, a Ph.D. student in the Neuroscience program at the Jefferson College of Graduate Studies, used their rat model to study the effects of alcohol on rats who suffer recurrent migraines, compared to rats that do not get headaches. They analyzed four groups of rats: two groups received repeated dural simulation, followed by an oral ingestion of saline or alcohol (the equivalent of one to two shots of liquor). Two control groups received no inflammatory stimulation, and received the similar oral ingestion of saline or alcohol.

Migraine headaches are associated with hypersensitivity to light, sound and light touch on the head and face. The researchers measured the rats' sensitivity to touch around the eye, using von Frey monofilaments. They monitored the change in pain threshold of the face resulting from the repeated dural stimulation.

The rats that received dural stimulation followed by alcohol showed an initial analgesic effect within the first two hours after alcohol ingestion. However, four to six hours later, their pain sensitivity increased, indicating a more painful state. There were no changes in alcohol-induced sensitivity in the control groups.

"Our results suggest that dehydration or impurities in alcohol are not responsible for hangover headache," Dr. Oshinsky said. "Since these rats were sufficiently hydrated and the alcohol they received contained no impurities, the alcohol itself or a metabolite must be causing the hangover-like headache. These data confirm the clinical observation that people with migraine are more susceptible to alcohol-induced headaches."

Dr. Oshinsky and his laboratory are now also studying the mechanism for the induction of headache, and also the metabolites of alcohol that cause hangover.


'/>"/>

Contact: Emily Shafer
emily.shafer@jefferson.edu
215-955-6300
Thomas Jefferson University
Source:Eurekalert

Related medicine news :

1. Migraine Research Foundation Announces Winners of 2009 Research Grants
2. New Migraine Drug Shows Promise
3. Jefferson Headache Center study shows novel, orally inhaled migraine therapy effective
4. Latest Holiday Migraine Survey Results Published
5. While Some New Agents Will Achieve Strong Sales, the Migraine Drug Market Will Decline $1.3 Billion by 2018 as Generic Erosion Takes Toll on Top-Selling Brands
6. Plastic Surgery Technique Might Ease Migraines
7. Migraines Linked to Reduced Breast Cancer Risk
8. Link between migraines and reduced breast cancer risk confirmed in follow-up study
9. Migraine Frequency Tied to Stroke, Heart Attack Risk
10. Smoking more than 5 cigarettes a day provokes migraine attacks
11. Migraine With Aura May Lead to Brain Lesions
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... ... 25, 2016 , ... The temporary closing of Bruton Memorial Library on June 21 due to ... a new, often overlooked aspect of head lice: the parasite’s ability to live away from ... common occurrence, but a necessary one in the event that lice have simply gotten out ...
(Date:6/25/2016)... Lewisville, TX (PRWEB) , ... June 25, 2016 , ... ... in the United States, named Dr. Sesan Ogunleye, as the Medical Director of its ... be the facility Medical Director of our new Mesquite location,” said Dr. James M. ...
(Date:6/25/2016)... Oklahoma (PRWEB) , ... June 25, 2016 , ... ... both athletes and non-athletes recover from injury. Recently, he has implemented orthobiologic procedures ... Oklahoma City area —Johnson is one of the first doctors to perform the ...
(Date:6/25/2016)... ... June 25, 2016 , ... Conventional wisdom preaches the ... In terms of the latter, setting the bar too high can result in disappointment, ... just slow progress toward their goal. , Research from PsychTests.com reveals ...
(Date:6/24/2016)... ... June 24, 2016 , ... Those who have experienced traumatic ... many turn to unhealthy avenues, such as drug or alcohol abuse, as a coping ... released tools for healthy coping following a traumatic event. , Trauma sufferers tend to ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... June 23, 2016 Research and Markets ... Market - Forecast to 2022" report to their offering. ... method for the patients with kidney failure, it replaces the ... from the patient,s blood and thus the treatment helps to ... chloride in balance. Increasing number of ESRD ...
(Date:6/23/2016)... , June 23, 2016 Roche (SIX: RO, ... clearance for its Elecsys BRAHMS PCT (procalcitonin) assay as ... or septic shock. With this clearance, Roche is the ... fully integrated solution for sepsis risk assessment and management. ... bacterial infection and PCT levels in blood can aid ...
(Date:6/23/2016)... Bracket , a leading clinical trial technology and specialty ... Bracket eCOA (SM) 6.0, at the 52 nd ... in Philadelphia , Pennsylvania.  A demonstration of ... its kind to fully integrate with RTSM, will be held ... a flexible platform for electronic clinical outcomes assessments that is ...
Breaking Medicine Technology: