Standardized measures of cognitive abilities such as memory, concentration, and attention did not show significant losses among people with migraine-associated lesions compared to those without migraine. The brain changes that give rise to the bright spots seen on MRI are unknown. More research is needed to find out if these are related to ischemia and ischemic stroke risk, according to the researchers.
The findings, which appear in the Nov. 14th issue of the Journal of the American Medical Association, update observations from an investigation conducted in 2000 showing that women with migraines were more likely than age-matched controls to have scattered areas of white matter changes on MRI scans. That initial population-based study, known as the Cerebral Abnormalities in Migraine, an Epidemiological Risk Analysis (CAMERA-1), screened and evaluated 295 men and women with migraine and compared them with 140 age- and sex-matched controls. In that study, people who had more frequent migraines also had a higher incidence of changes seen on their MRIs, suggesting that migraine attacks could have a cumulative effect.
In the current investigation, known as CAMERA-2, researchers sought to tease out differences between men and women, and to find out whether the type of migraine was associated with an increase in the volume of new white matter changes relative to that seen in the initial study. Researchers reassessed 286 of the original participants. Among them, 114 had migraine with aura, 89 had migraine without aura, and 83 were controls.
Compared with baseline, women with migraines were twice as likely as those without such attacks to have an increase in the volume of diffuse white matter changes. However, this increase was still very small, said one of the study's investigators, Lenore J. Launer, Ph.D., chief of the Neuroepidemiology Section at the National Institute on Agi
|Contact: Kathryn DeMott|
NIH/National Institute of Neurological Disorders and Stroke