Navigation Links
Migraine, Depression May Have Genetic Link
Date:1/13/2010

Study found those who had migraines more likely to suffer depression

WEDNESDAY, Jan. 13 (HealthDay News) -- Two seemingly unrelated problems might share a genetic component that may make some people more likely to suffer from both migraine and depression, Dutch researchers report.

The connection between migraine and depression has been examined before, but these researchers show that genetics may be the missing link between these two conditions.

"Migraine and depression co-occur far more frequently within subjects than to be expected by chance," said lead researcher Dr. Gisela M. Terwindt, an assistant professor of neurology at Leiden University Medical Center. "This relationship is bidirectional; migraine patients have an increased risk to develop depression and, vice versa, depressed subjects have an increased risk of getting migraine attacks," she said.

The report is published in the Jan. 13 online edition of Neurology.

For the report, Terwindt's team collected data on 2,652 people who took part in the Erasmus Rucphen Family study and were all descendants of 22 couples who lived in Rucphen in the 1850s to 1900s.

Among these people, 360 suffered from migraine, 151 of them had migraine with aura, and 977 had depression. In the latter type of migraine, the headache is preceded by flashes of light. Twenty-five percent of those with migraines also suffered from depression, compared to 13 percent of those without migraines, the researchers found.

Using this data, Terwindt's group was able to estimate the genetic contribution to both migraine and depression. They found that genetics explained 56 percent of all migraine. For migraine with aura, genetics accounted for 96 percent.

In addition, when they looked at the genetics of having both migraine and depression, the researchers found a shared genetic component, particularly for migraine with aura, Terwindt said. "Migraine patients have, at least partly, a genetic predisposition for depression," she noted.

In the future, knowing the genetics of these conditions may lead to better treatment and possibly prevention, she said.

"Identification of common genetic factors may significantly improve the insight into the molecular basis of both migraine and depression," Terwindt said. "This may help in the future to get more insight in the common pathophysiological process underlying both of these disabling disorders. This will, hopefully, lead to prevention of chronic migraine and development of tailored prophylactic treatments."

Dr. Gretchen E. Tietjen, chairwoman of neurology and director of the Headache Treatment and Research Program at University of Toledo Medical Center in Ohio, said that while genetics play a part in both migraine and depression, it may well take an environmental trigger to actually produce either condition.

Tietjen recently published a series of studies that found that children who experienced abuse or neglect were more likely to suffer from migraine and depression as adults.

"Physical, emotional or sexual abuse, and physical and emotional neglect were strongly tied to depression and other conditions that are found with migraine," she said.

Tietjen noted that stress in early life can permanently change the brain.

"Genetics is really important, and environment probably is important for turning some of these things on," she added.

More information

For more information on migraine, visit the U.S. National Library of Medicine.



SOURCES: Gisela M. Terwindt, M.D., Ph.D., assistant professor, neurology, Leiden University Medical Center, the Netherlands; Gretchen E. Tietjen, M.D., professor and chairwoman, neurology, and director, Headache Treatment and Research Program, University of Toledo Medical Center, Ohio; Jan. 13, 2010, Neurology, online


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Clinical depression linked to abnormal emotional brain circuits
2. Depression Taking Toll on Returning U.S. Vets
3. Damp, Moldy Homes May Cause Depression
4. Treating depression may improve recovery of heart rate variability following coronary syndromes
5. Study finds primary care depression treatment often does not follow quality guidelines
6. Hot ice, measuring depression, perfect invisibility and flu vaccine incentives
7. Depression May Be Worlds Most Disabling Disease
8. Depression Pushes Middle-Aged Workers to Retire
9. Maternal depression and controlling behavior associated with increased stress response in infants
10. Brain atrophy in elderly leads to unintended racism, depression and problem gambling
11. Lauren Marangell, M.D. to Join Lilly; Internationally Recognized Expert in Depression Joins as Distinguished Lilly Scholar
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/8/2016)... , ... February 08, 2016 , ... ... its newly redesigned website, federallabs.org . The site houses a wealth of ... available federal technologies through the process called technology transfer (T2). As a network ...
(Date:2/8/2016)... ... ... famous for gift giving with flowers, chocolates and other tokens of affection meant to remind ... than 5.6 million Americans suffering with Alzheimer’s, those store bought gifts - no matter ... they’ve led and the people they’ve touched. , That’s why Give To ...
(Date:2/8/2016)... , ... February 08, 2016 , ... ... and clothing, announced expansion into Canada to provide its range of unique and ... sales office in Quebec City that will provide bilingual customer service and marketing ...
(Date:2/8/2016)... , ... February 08, 2016 , ... Delta Dental of ... help combat pancreatic cancer. , Gary D. Radine, who recently retired as president and ... American Cancer Society’s 2015 CEO of the Year , helped lead the effort ...
(Date:2/8/2016)... ... 08, 2016 , ... FileHold's document management software has been ... cloud hosted environment for FileHold software that is pay per user subscription-based and ... using the FileHold web services API. DocuSyst also advises clients on fully functioning ...
Breaking Medicine News(10 mins):
(Date:2/5/2016)... LOS ANGELES , Feb. 5, 2016  Redwood ... of a new product designed to help women balance ... oral strip delivery technology. Jason Cardiff ... company will be able to help the millions of ... suffer from the effects of imbalanced hormones. Our research ...
(Date:2/5/2016)... -- ivWatch, a medical devices company, is one of five recipients ... Terry McAuliffe,s office. ivWatch will be receiving the ... event to be held at the Science Museum of ... business that have made significant contributions to science. ... ...
(Date:2/5/2016)... in Alabama seeking prostate care with ... have to travel out of state. Vituro Health ... of Alabama to provide a total prostate management program ... Alabama is known throughout the ... using many different modalities. They are the largest and one ...
Breaking Medicine Technology: