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Microscopic 'beads' could help create 'designer' immune cells that ignore transplanted organs
Date:7/6/2009

presented the patented process along with his other latest HLA-G findings during an opening lecture of the 5th International Conference on HLA-G in Paris, July 6-8.

Marked microparticles also have treatment potential in diseases where the immune system attacks normal tissue, such as arthritis, multiple sclerosis and inflammatory bowel disease, Dr. Horuzsko says. Conversely the method could be used to deliver a compound to block HLA-G activity, which also is heightened in tumors.

The scientist also is working with Dr. Laura Mulloy, chief of the Section of Nephrology, Hypertension and Transplantation Medicine in the MCG School of Medicine, to determine if higher natural levels of HLA-G already are giving some transplant patients an edge by comparing HLA-G expression in those who keep and reject their transplanted kidneys

Dr. Horuzsko reported last year in Proceedings of the National Academy of Sciences that the dimer form of HLA-G was the most powerful of the known forms and now he and many others are searching for the most powerful dimer, hoping the most successful transplant patients will help them make that call.

HLA-G works through inhibitory receptors, ILT2, ILT3 and ILT4, on dendritic cells, triggering a signaling pathway in which several suppressive molecules get activated to help protect the transplanted organ or tissue. Human leukocyte antigen G, or HLA-G, actually is a member of a gene family called major histocompatibility complex that typically provokes an immune response. Like an errant child, HLA-G instead promotes tolerance, Dr. Horuzsko says.


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Contact: Toni Baker
tbaker@mcg.edu
706-721-4421
Medical College of Georgia
Source:Eurekalert  

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Microscopic 'beads' could help create 'designer' immune cells that ignore transplanted organs
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