Microscopic 'beads' could help create 'designer' immune cells that ignore transplan... ( AUGUSTA Ga. The future of organ tra...)

Microscopic 'beads' could help create 'designer' immune cells that ignore transplanted organs

Date:7/6/2009

AUGUSTA, Ga. The future of organ transplantation could include microscopic beads that create "designer" immune cells to help patients tolerate their new organ, Medical College of Georgia researchers say.

"It's absolutely natural," says Dr. Anatolij Horuzsko, reproductive immunologist at the MCG Center for Molecular Chaperone/Radiobiology and Cancer Virology, who has used the approach successfully in mice with skin grafts.

The degradable microparticles deliver the most powerful known form of HLA-G, a natural suppressor of the immune response, straight to dendritic cells, which typically show the immune system what to attack. The microparticles are given right after a transplant, just as dendritic cells are giving the immune system a heads up to get busy attacking the new organ.

Microparticle therapy likely would be needed for just a few weeks, until the dendritic cells have learned instead to ignore it, Dr. Horuzsko says. "It's like a calming effect and once tolerance is established, we don't need it any more."

His lab reported its success with this delivery method in mice with skin grafts last month in Human Immunology. When researchers compared the success of HLA-G microparticles with the dendritic cell marker to those without a marker, those with were much more efficient at getting where needed and acting, he says. Those without direction likely were consumed by garbage eaters called macrophages.

Unlike current anti-rejection drugs that generally suppress the immune system leaving patients vulnerable to infections, cancer and more HLA-G offers specific "tolerance." Fetuses, which also use the compound to escape rejection by the mother's immune system, are good examples of the specific tolerance HLA-G affords, Dr. Horuzsko says.

"We want to create in kidney transplant patients, the same tolerance to the new kidney." Within five years, HLA-G microparticles could be doing just that, Dr. Horuzsko says. He
'/>"/>

Contact: Toni Baker
tbaker@mcg.edu
706-721-4421
Medical College of Georgia
Source:Eurekalert

0

GOOD

Page: 1 2
Related medicine news :

1. Microscopic manufacturers produce eco-friendly plastics
2. The Power of a Tiny Microscopic Plant Found To Reduce Computer Eye Strain
3. Lung Cancer Microscopic Appearance Affects Response to Chemotherapy
4. Microscopic astronauts to go back in orbit
5. Tiny Chemo Beads Boost Liver Cancer Outcomes
6. Hair Beads Spurring Head Trauma in Kids
7. New Jefferson trial to test radiation-emitting beads against advanced liver cancer
8. CycleBeads help women manage their fertility
9. Rare sheep could be key to better diagnostic tests in developing world, says Stanford study
10. C-Section Stress Could Alter Babys Immune Cells
11. New Drug Could Work Against Leukemia

Post Your Comments:

Related Image:

Microscopic 'beads' could help create 'designer' immune cells that ignore transplanted organs

(Date:5/19/2013)... (PRWEB) May 20, 2013 Due to ... with online advertising, MileageAds.com has decided to invite bloggers ... through their ad network. , Businesses in the ... success with online marketing, specifically with ad networks. ... information and legal services and are unsure where to ...

(Date:5/19/2013)... physicians are key decisionmakers for nearly half of all ... in reducing health care costs, according to a new ... admissions from the ER increased by 17 percent over ... hospital admissions between 2003 and 2009. Hospital inpatient ... accounting for 31 percent of the nation,s health care ...

(Date:5/19/2013)... New York, NY (PRWEB) May 19, 2013 ... tickets for his two concerts in Vegas in October ... 20th. Additionaly, during the spring and summer months of ... the country. , Whenever people hear “It’s Five ... and hear the voice of Jimmy Buffett inside their heads. ...

(Date:5/19/2013)... (PRWEB) May 19, 2013 Daily Gossip reporters ... 17 Cheat Foods That Burn Fat to a ... readers. , The review is a detailed ... by the writer's recommendation. , The two nutritionists have discovered ... is responsible for the caloric intake and expenditure of our ...

(Date:5/19/2013)... May is officially known as Skin Cancer Awareness ... Australia, the country's forerunner in fashionable children’s sun ... to kick off their month long mission to bring ... staggering number of cancer cases diagnosed each year, the ... out what’s causing the epidemic and how to stop ...

Breaking Medicine News(10 mins):Health News:Mileageads Ad Network Now Invites Bloggers and Business Owners in Mesothelioma Sector to Advertise on Their Ad Network 2 Health News:ER docs are key to reducing health care costs 2 Health News:ER docs are key to reducing health care costs 3 Health News:Jimmy Buffett Las Vegas Tickets: Jimmy Buffett Tickets in Vegas at the MGM Grand on Oct. 19 and Oct. 26 Go on Public Sale Monday, May 20 at 10:00 a.m. Local Time 2 Health News:Jimmy Buffett Las Vegas Tickets: Jimmy Buffett Tickets in Vegas at the MGM Grand on Oct. 19 and Oct. 26 Go on Public Sale Monday, May 20 at 10:00 a.m. Local Time 3 Health News:The "17 Cheat Foods That Burn Fat" Review and Diet Plan Secrets Revealed by Daily Gossip 2 Health News:Leading Children’s Sun Protection Swimwear Company Platypus Australia use Skin Cancer Awareness Month to Help Educate Parents 2 Health News:Leading Children’s Sun Protection Swimwear Company Platypus Australia use Skin Cancer Awareness Month to Help Educate Parents 3

[0] Mileageads Ad Network Now Invites Bloggers and Business Owners in Mesothelioma Sector to Advertise on Their Ad Network [0] ER docs are key to reducing health care costs [0] Jimmy Buffett Las Vegas Tickets: Jimmy Buffett Tickets in Vegas at the MGM Grand on Oct. 19 and Oct. 26 Go on Public Sale Monday, May 20 at 10:00 a.m. Local Time [0] The "17 Cheat Foods That Burn Fat" Review and Diet Plan Secrets Revealed by Daily Gossip [0] Leading Children’s Sun Protection Swimwear Company Platypus Australia use Skin Cancer Awareness Month to Help Educate Parents

... Multimedia Effort to Launch Contact Lenses in Puerto ... ... 28 Johnson & Johnson Vision,Care, today announced a multi-faceted marketing campaign ... Contact Lenses in Puerto Rico, the Caribbean and Central,America., Following its ...

... in Heavy Rotation Through Primary, OAKLAND, Calif., ... crucial,primary vote Tuesday, the National Nurses Organizing Committee/California,Nurses ... Ohio with,an emphatic message to the presidential candidates ... healthcare reform., The 60-second radio ad is ...

... lupus erythematosus (SLE), commonly known as lupus, can affect ... skin, kidneys, heart, nervous system, and brain. Along ... and skin rashes, neurologic and psychiatric events often accompany ... 37 and 95 percent of SLE patients experience signs ...

... Kimmel Cancer Center in Philadelphia have shown that they ... laboratory and in experimental animal models by blocking a ... The work proves that the protein, Stat5, is both ... is a viable target for drug therapy. , The ...

... Year 2007 Highlights, - Revenue for the fourth quarter was $469.5 ... year was $1.8 billion, a 40% ... - Average occupancy for the fourth quarter was 90.6% and for the full ... from 90.4% for the full year of 2006., - Same store Facility ...

... 27 Actavis Group, the,international generic pharmaceuticals company, ... U.S. Food & Drug Administration., The four ... generic equivalent of,Bontril(R) tablets by Valeant Pharmaceuticals, are ... sales of Phendimetrazine tartrate tablets,had annual sales of ...

Eyes on Puerto Rico: Johnson & Johnson Markets New Contact Lenses Directly to Consumers Nurses Launch Major Ohio Radio Ad Campaign Telling Candidates: Stop Selling Insurance and Back Real Reform Autoantibodies and neuropsychiatric events in lupus Blocking protein kills prostate cancer cells, inhibits tumor growth, Jefferson scientists find Brookdale Announces Fourth Quarter and Full Year 2007 Results Actavis Extends Portfolio With Four New Products in the U.S.

(Date:5/17/2013)... 17, 2013 Technology advances have had a ... with a constantly evolving communication environment, companies need ... communicating with internal executives. It is challenging, however, ... tactics and tools that are part of today,s ... study, Best Practices, LLC explores the various internal ...

(Date:5/17/2013)... -- United Medical Education, a company that provides online ... Life Support (PALS) and Basic Life Support (BLS), is ... course manuals. In order to gain access to ... account with the company. By offering the free learning ... is setting a precedent among similar companies. ...

(Date:5/17/2013)... 17, 2013 /PRNewswire-iReach/ -- The escalation of new ... placing renewed emphasis on alternate delivery technologies. Alternate ... number of factors are converging to create both ... their delivery device partners . These include new ... growing trend toward self-administration for chronic diseases, shifting ...

Breaking Medicine Technology:Internal Communication Strategies and Tactics that Resonate with Key Stakeholders and Drive Organizational Effectiveness 2 ACLS Online Course Manuals are Now Available at No Cost through United Medical Education 2 Pharmaceutical Makers and Delivery Device Partners Rethink Delivery Technologies - New Report Examines this Evolving Segment 2 Pharmaceutical Makers and Delivery Device Partners Rethink Delivery Technologies - New Report Examines this Evolving Segment 3

[0] Internal Communication Strategies and Tactics that Resonate with Key Stakeholders and Drive Organizational Effectiveness [0] ACLS Online Course Manuals are Now Available at No Cost through United Medical Education [0] Pharmaceutical Makers and Delivery Device Partners Rethink Delivery Technologies - New Report Examines this Evolving Segment

... 20, 2011 Misonix, Inc. (NASDAQ: ... manufactures and markets innovative therapeutic ultrasonic products worldwide ... and other surgical and medical applications, has announced ... against it by PuriCore International Limited and PuriCore ...

... 20, 2011 Medical Device Consultants, Inc. (MDCI), a ... device industry, announced today that Mr. Frederick (Fred) Tobia ... clinical services. He will oversee the daily operations of ... Vicki Anastasi, vice president of regulatory services and business ...

Cached Medicine Technology:Misonix Announces Settlement of PuriCore Litigation, Including Entry into a U.S. Distribution Agreement for PuriCore's Advanced Wound Care Product 2 Misonix Announces Settlement of PuriCore Litigation, Including Entry into a U.S. Distribution Agreement for PuriCore's Advanced Wound Care Product 3 Misonix Announces Settlement of PuriCore Litigation, Including Entry into a U.S. Distribution Agreement for PuriCore's Advanced Wound Care Product 4 Medical Device Consultants, Inc. Welcomes Frederick Tobia as Director of Regulatory and Clinical Services 2

Misonix Announces Settlement of PuriCore Litigation, Including Entry into a U.S. Distribution Agreement for PuriCore's Advanced Wound Care Product Medical Device Consultants, Inc. Welcomes Frederick Tobia as Director of Regulatory and Clinical Services

When You Need Optimal Patient Comfort with Minimal Weight at a Nonunion Site...Demand The OrthoPak Noninvasive Bone Growth Stimulator. , ,Most Appropriate for the Proximal Femur, Metatarsal/Tar...

... Pulsed ElectroMagnetic Field (PEMF) bone growth stimulation ... option for long bone and small bone ... cast, orthopedic brace, or clothing without lessening ... in one compact, lightweight unit including success ...

Our products, with carefully researched design features, are tailored to making arthroscopic and ligament reconstructive surgery more reproducible, easier, quicker and safer....

... Cannulated Interference Screws. Optimal ... and graft selection options. ... without deformation, and chamfered ... threaded atraumatic tissue fixation. ...

Medicine Products:

BioElectron Orthopak Physio-Stim Bone Growth Stimulator Interference Screws ABSOLUTE Absorbable Cannulated Interference Screws