Navigation Links
Microneedle vaccine patch boosts flu protection through robust skin cell immune response
Date:3/5/2012

Recent research found that microneedle vaccine patches are more effective at delivering protection against influenza virus in mice than subcutaneous or intramuscular inoculation. A new, detailed analysis of the early immune responses by the Emory and Georgia Tech research team helps explain why the skin is such fertile ground for vaccination with these tiny, virtually painless microneedles.

The research was published in the January/February issue of the online journal mBio.

The skin, in contrast to the muscles, contains a rich network of antigen-presenting cells, which are immune signaling cells that are essential to initiating an immune response. The researchers found that microneedle skin immunization with inactivated influenza virus resulted in a local increase of cytokines important for recruitment of neutrophils, monocytes and dendritic cells at the site of immunization. All these cells play a role in activating a strong innate immune response against the virus.

Microneedle vaccination also may lead to prolonged depositing of antigen the viral molecules that are the targets of antibody responses. Such a prolonged antigen release could allow more efficient uptake by antigen-presenting cells. In addition, activated and matured dendritic cells carrying influenza antigen were found to migrate from the skin an important feature of activating the adaptive immune response.

The research was led by first author Maria del Pilar Martin, PhD and Richard W. Compans, PhD, Emory professor of microbiology and immunology. Other authors included William C. Weldon, Dimitrios G. Koutsonanos, Hamed Akbari, Ioanna Skountzou, and Joshy Jacob from Emory University and Vladimir G. Zarnitsyn and Mark R. Prausnitz from Georgia Tech.

"Our research reveals new details of the complex but efficient immune response to influenza virus provided by microneedle skin patches," says Compans. "Despite the success of vaccination against influenza, the virus has many subtypes, mutates rapidly and continues to elude complete and long-term protection, and therefore requires annual vaccination with an updated vaccine each year.

"New vaccine formulations and delivery methods such as vaccine-coated microneedle patches could provide an improved protective response, which would be of particular benefit to those at high risk of related complications. Vaccine delivery to the skin by microneedles is painless, and offers other advantages such as eliminating potential risks due to use of hypodermic needles."


'/>"/>

Contact: Holly Korschun
hkorsch@emory.edu
404-727-3990
Emory University
Source:Eurekalert

Related medicine news :

1. New microneedle antimicrobial techniques may foster medical tech innovation
2. Vaccine May Prevent TB in People With HIV
3. Vaccine Not Fail-Safe in Ongoing Mumps Outbreak
4. New strategy produces promising advance in cancer vaccines
5. Screens, Vaccine for HPV Less Beneficial in Older Women
6. New Technology Could Widen Reach of Vaccines
7. Texas-based consortium announces groundbreaking vaccine research program
8. The Coalition for Vaccine Safety Calls for Congressional Hearings on Federal Agencies Failure to Provide Adequate Safety Research
9. Possible vaccine for mesothelioma proven safe
10. Groundbreaking research to find vaccine for hepatitis C
11. Vaccine for Asbestos-Related Cancer Looks Safe
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... October 13, 2017 , ... ProVest Insurance Group, a family ... and Raleigh regions, is organizing an extended charity drive to benefit the family ... abnormality. , After struggling since birth with several health challenges, T.J. was later ...
(Date:10/13/2017)... ... October 13, 2017 , ... The International Association of Eating ... excellence for the field of eating disorders, announces the opening of early registration ... Orlando, Florida at the Omni Resort at ChampionsGate. , The annual ...
(Date:10/13/2017)... , ... October 13, 2017 , ... Many families have ... many long-term care insurance companies have a waiver for care if the client has ... period, when the family pays for care, is often waived, so the benefits from ...
(Date:10/13/2017)... , ... October 13, 2017 , ... ... be giving viewers the lowdown on sciatica in a new episode of "Success ... focuses on current events and innovation and investigates each subject in-depth with passion ...
(Date:10/12/2017)... ... October 12, 2017 , ... CitiDent and ... apnea using cutting-edge Oventus O2Vent technology. As many as 18 million Americans ... frequent cessation in breathing. Oral appliances can offer significant relief to about 75 ...
Breaking Medicine News(10 mins):
(Date:9/25/2017)... Sept. 25, 2017  EpiVax, Inc., a leader ... and immune-engineering today announced the launch of EpiVax ... of personalized therapeutic cancer vaccines. EpiVax has provided ... access to enabling technologies to the new precision ... lead EpiVax Oncology as Chief Executive Officer. Gad ...
(Date:9/19/2017)... Ky. , Sept. 19, 2017   ZirMed Inc ... predictive analytics, today announced that it has been ranked #1 ... Black Book™ Rankings 2017 User Survey. ZirMed was ... solution for large hospitals and medical centers over 200 beds ... Black Book,s healthcare technology user survey history. ...
(Date:9/12/2017)... LAKES, N.J. , Sept. 12, 2017  Consumer reviews on ... Embrace Hearing as the number one company for hearing aids, ... ReSound™ and fifteen other brands. ... Embrace Hearing Named #1 by Consumers For Hearing Aids ... Embrace Hearing is an online store that provides ...
Breaking Medicine Technology: