Navigation Links
Microneedle vaccine patch boosts flu protection through robust skin cell immune response
Date:3/5/2012

Recent research found that microneedle vaccine patches are more effective at delivering protection against influenza virus in mice than subcutaneous or intramuscular inoculation. A new, detailed analysis of the early immune responses by the Emory and Georgia Tech research team helps explain why the skin is such fertile ground for vaccination with these tiny, virtually painless microneedles.

The research was published in the January/February issue of the online journal mBio.

The skin, in contrast to the muscles, contains a rich network of antigen-presenting cells, which are immune signaling cells that are essential to initiating an immune response. The researchers found that microneedle skin immunization with inactivated influenza virus resulted in a local increase of cytokines important for recruitment of neutrophils, monocytes and dendritic cells at the site of immunization. All these cells play a role in activating a strong innate immune response against the virus.

Microneedle vaccination also may lead to prolonged depositing of antigen the viral molecules that are the targets of antibody responses. Such a prolonged antigen release could allow more efficient uptake by antigen-presenting cells. In addition, activated and matured dendritic cells carrying influenza antigen were found to migrate from the skin an important feature of activating the adaptive immune response.

The research was led by first author Maria del Pilar Martin, PhD and Richard W. Compans, PhD, Emory professor of microbiology and immunology. Other authors included William C. Weldon, Dimitrios G. Koutsonanos, Hamed Akbari, Ioanna Skountzou, and Joshy Jacob from Emory University and Vladimir G. Zarnitsyn and Mark R. Prausnitz from Georgia Tech.

"Our research reveals new details of the complex but efficient immune response to influenza virus provided by microneedle skin patches," says Compans. "Despite the success of vaccination against in
'/>"/>

Contact: Holly Korschun
hkorsch@emory.edu
404-727-3990
Emory University
Source:Eurekalert

Page: 1 2

Related medicine news :

1. New microneedle antimicrobial techniques may foster medical tech innovation
2. Vaccine May Prevent TB in People With HIV
3. Vaccine Not Fail-Safe in Ongoing Mumps Outbreak
4. New strategy produces promising advance in cancer vaccines
5. Screens, Vaccine for HPV Less Beneficial in Older Women
6. New Technology Could Widen Reach of Vaccines
7. Texas-based consortium announces groundbreaking vaccine research program
8. The Coalition for Vaccine Safety Calls for Congressional Hearings on Federal Agencies Failure to Provide Adequate Safety Research
9. Possible vaccine for mesothelioma proven safe
10. Groundbreaking research to find vaccine for hepatitis C
11. Vaccine for Asbestos-Related Cancer Looks Safe
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... (PRWEB) July 11, 2014 Los ... announces that he uses mini and full mouth implants ... the defining feature that distinguishes dental implants from other ... addition to the crowns. This alone prevents the long-term ... also offer advantages related to comfort, appearance and systemic ...
(Date:7/11/2014)... Maureen Salamon HealthDay ... -- For the millions of women who can,t cough, ... testing a treatment that uses stem cells to regenerate ... European researchers found that injecting stem cells isolated from ... in all participants within a year. Stress ...
(Date:7/11/2014)... July 11, 2014 Recent research findings regarding ... the atmosphere, and how water affects human bodies. That was ... Pollack, during an interview on the Sharon Kleyne Hour Power ... , Gerald Pollack, PhD, is a Professor of Bioengineering ... Fourth Phase of Water (Ebner & Sons, 2013). ...
(Date:7/11/2014)... July 11, 2014 Shoulder instability is ... of return to play has not been regularly determined ... Orthopaedic Society for Sports Medicine’s ( AOSSM ) Annual ... is approximately 90 percent no matter what the stabilization ... success rate of return to play following shoulder stabilization ...
(Date:7/11/2014)... reconstructions occur more than 200,000 times a year, but ... ligament may determine how long you stay in the ... Annual Meeting of the American Orthopaedic Society of Sports ... that in a young athletic population, allografts (tissue harvested ... (tissue harvested from the patient)," said Craig R. Bottoni, ...
Breaking Medicine News(10 mins):Health News:Dental Implant Dentist, Kevin Sands DDS, Now Uses Mini and Full Mouth Implants to Replace Missing Teeth 2Health News:Stem Cells May Ease Urinary Incontinence, Study Says 2Health News:Stem Cells May Ease Urinary Incontinence, Study Says 3Health News:Recent Fourth Phase Water Discoveries Alter Basic Understanding of Life, Claims Researcher on Sharon Kleyne Hour 2Health News:Recent Fourth Phase Water Discoveries Alter Basic Understanding of Life, Claims Researcher on Sharon Kleyne Hour 3Health News:Stabilizing Shoulder Surgery Helps NFL Players Return to the Game 2Health News:ACL reconstructions may last longer with autografts 2
... spikes a high fever, sometimes as high as 104 or ... emergency room, the hospital runs test after test, specialists are ... though no one knows how many go through ... arent accompanied by any obvious symptoms and dont respond to ...
... BUFFALO, N.Y. -- For a rich source of stem cells ... clinicians may one day look no further than the hair ... this month by University at Buffalo engineers. , ... new blood vessels or regenerating new skin tissue using stem ...
... Governor Edward G.,Rendell today released the text of his ... deadline for MCare fund assessment payments:, Dear Health ... that the state was in a unique,position to extend ... to affordable health care for hundreds of thousands of ...
... THE GOVERNMENT CURB AN OVERLY AGGRESSIVE VACCINATION SCHEDULE ... 28 Parents of children who,regressed into autism ... health officials may at last be catching on ... article published on Huffington Post by investigative journalist,David ...
... currently Dean of Research and Graduate Education in the ... University (JHU), has,been appointed Chief Executive Officer and Executive ... the,position on July 1, 2008. A published author in ... JHU and at JHU has served,as department chair of ...
... warn doctors early to change treatments , , FRIDAY, March ... they may have found a blood marker that denotes ... The researchers found an increase in the CD163+/CD16+ monocyte ... virus (HIV), according to a study published in the ...
Cached Medicine News:Health News:Mysterious fevers of unknown origin: Could surgery be a cure? 2Health News:Stem cells from hair follicles may help 'grow' new blood vessels 2Health News:Governor Rendell Writes to Physicians to Explain MCare Fund Assessment Deadline 2Health News:MITOCHONDRIAL DYSFUNCTION, VACCINES AND AUTISM: 1 in 50 Children Could Be at Risk 2Health News:Hauptman-Woodward Appoints Dr. Eaton Lattman CEO and Executive Director 2Health News:Hauptman-Woodward Appoints Dr. Eaton Lattman CEO and Executive Director 3Health News:Biomarker May Signal HIV Progression 2
(Date:7/10/2014)... 2014  RESMED INC. (NYSE: RMD ) today ... year ended June 30, 2014 results on Thursday, July 31, ... press release with ResMed,s results will be issued after 1:00 ... webcast to discuss operating results and future outlook. ... US Pacific Time and the live webcast of the call ...
(Date:7/10/2014)... Mass. , July 10, 2014  Decision ... of surveyed infectious disease (ID) specialists are willing ... Company,s Orbactiv (oritavancin) for use as OPAT, approximately ... prescribe these agents to their hospital inpatients. However, ... of OPAT patients are initiated on OPAT following ...
(Date:1/15/2014)... -- ChinaMarketResearchReports.com adds "China Orthopedic Instrument Industry Report, 2013-2015" ... (Photo: http://photos.prnewswire.com/prnh/20140115/MN46792 ) Benefiting from aging ... China,s orthopedic instrument industry has seen rapid ... from 3.28 billion yuan in 2006 to 9.85 billion ...
Breaking Medicine Technology:ResMed To Announce Fourth Quarter And Fiscal Year-End 2014 Results 2Long-Acting Antibiotics Offering Once-Weekly Dosing Will See Favorable Uptake and Use as Outpatient Parenteral Antimicrobial Therapy (OPAT) 2Long-Acting Antibiotics Offering Once-Weekly Dosing Will See Favorable Uptake and Use as Outpatient Parenteral Antimicrobial Therapy (OPAT) 3Orthopedic Instrument Industry in China Markets Forecast to 2015 2Orthopedic Instrument Industry in China Markets Forecast to 2015 3
... ... ... ... ...
... ... ... ... ...
Cached Medicine Technology:Volcano Reports 44 Percent Increase in Fourth Quarter Revenues 2Volcano Reports 44 Percent Increase in Fourth Quarter Revenues 3Volcano Reports 44 Percent Increase in Fourth Quarter Revenues 4Volcano Reports 44 Percent Increase in Fourth Quarter Revenues 5Volcano Reports 44 Percent Increase in Fourth Quarter Revenues 6Volcano Reports 44 Percent Increase in Fourth Quarter Revenues 7Volcano Reports 44 Percent Increase in Fourth Quarter Revenues 8Volcano Reports 44 Percent Increase in Fourth Quarter Revenues 9Volcano Reports 44 Percent Increase in Fourth Quarter Revenues 10Volcano Reports 44 Percent Increase in Fourth Quarter Revenues 11Volcano Reports 44 Percent Increase in Fourth Quarter Revenues 12Volcano Reports 44 Percent Increase in Fourth Quarter Revenues 13Volcano Reports 44 Percent Increase in Fourth Quarter Revenues 14Volcano Reports 44 Percent Increase in Fourth Quarter Revenues 15Volcano Reports 44 Percent Increase in Fourth Quarter Revenues 16Volcano Reports 44 Percent Increase in Fourth Quarter Revenues 17Volcano Reports 44 Percent Increase in Fourth Quarter Revenues 18Volcano Reports 44 Percent Increase in Fourth Quarter Revenues 19Volcano Reports 44 Percent Increase in Fourth Quarter Revenues 20Abbott to Collaborate With GSK on Molecular Diagnostic Test to Select Candidate Patients for Future Skin Cancer Immunotherapy 2Abbott to Collaborate With GSK on Molecular Diagnostic Test to Select Candidate Patients for Future Skin Cancer Immunotherapy 3Abbott to Collaborate With GSK on Molecular Diagnostic Test to Select Candidate Patients for Future Skin Cancer Immunotherapy 4Abbott to Collaborate With GSK on Molecular Diagnostic Test to Select Candidate Patients for Future Skin Cancer Immunotherapy 5Abbott to Collaborate With GSK on Molecular Diagnostic Test to Select Candidate Patients for Future Skin Cancer Immunotherapy 6Abbott to Collaborate With GSK on Molecular Diagnostic Test to Select Candidate Patients for Future Skin Cancer Immunotherapy 7Abbott to Collaborate With GSK on Molecular Diagnostic Test to Select Candidate Patients for Future Skin Cancer Immunotherapy 8
The major innovation in posterior stabilized (PS) knee design. Improve patellofemoral kinematics. Reduce wear rate potential. Increase resistance to posterior tibial dislocation. Achieve at least 120...
... provides the adaptability surgeons need to make ... other way around. The wide selection of ... components allow surgeons to address the unexpected ... all with one instrument set. For cruciate ...
... minimally invasive uni-compartmental knee replacement is an ... surgery. This procedure provides patients with a ... knee.,Arthritis of the knee often results in ... quality of life and even depression. Orthopedic ...
... The Genesis II® Total Knee System will ... far more is possible with less - ... while fully addressing both clinical and cost ... these design goals, giving surgeons creative solutions ...
Medicine Products: