Navigation Links
Micromovements hold hidden information about severity of autism, researchers report
Date:12/2/2013

INDIANAPOLIS -- Movements so minute they cannot be detected by the human eye are being analyzed by researchers to diagnose autism spectrum disorder and determine its severity in children and young adults, according to research presented at the 2013 Society for Neuroscience annual meeting in November.

The research is the work of Jorge V. Jos, Ph.D., vice president of research at Indiana University, and Elizabeth Torres, Ph.D., the principal investigator for the study and an assistant professor in the Department of Psychology in the School of Arts and Sciences at Rutgers University. They are building on earlier findings involving the random nature of movements of people with autism. The work was presented in a poster by biophysics and neuroscience Ph.D. graduate student Di Wu, who works in Dr. Jos's lab.

Earlier research looked at the speed maximum and randomness of movement during a computer exercise that involved tracking the motions of youths with autism when touching an image on the screen to indicate a decision. That research was reported in July in the Nature journal Frontiers of Neuroscience.

In the new study, the researchers looked at the entire movement involved in raising and extending a hand to touch a computer screen. The device they use can record 240 frames per second, which allows them to measure speed changes in the millisecond range.

"We looked at the curve going up and the curve going down and studied the micromovements," said Dr. Jos, who also is the James H. Rudy Distinguished Professor of Physics in the IU Bloomington College of Arts and Sciences and a professor of cellular and integrative physiology at the IU School of Medicine.

"When a person reaches for an object, the speed trajectory is not one smooth curve; it has some irregular random movements we call 'jitter,'" he said. "We looked at the properties of those very small fluctuations and identified patterns." Those patterns or signatures also identify the degree of the severity of the person's autism spectrum disorder, he said.

"Often in movement research, such fluctuations are considered a nuisance," Dr. Jos said. "People averaged them away over repeated movements, but we decided instead to analyze the movements on a smaller time scale and found they hold lots of information to help diagnose the continuum of autism spectrum disorder.

"Looking at the speed versus time curves of the motion in much more detail, we noticed that in general many smaller oscillations or fluctuations occur even when the hand is resting in the lap. We decided to carefully study that jitter. Our remarkable finding is that the fluctuations in this jitter are not just random fluctuations, but they do correspond to unique characteristics of the degree of autism each child has."

Wu said the more detailed information allows subtyping autism spectrum disorder, Asperger's and identify typically developing individuals much better than what had been done before in terms of the global distribution of movements.

The next step is to compare the output of the new methodology in individuals with autism of idiopathic origins with those with autism of known etiology. The new refinement may help advance research in autism spectrum disorder to develop treatments tailored to the individual's needs and capabilities. A collaborative effort with the Torres lab at Rutgers is underway.


'/>"/>

Contact: Mary Hardin
mhardin@iu.edu
317-274-5456
Indiana University
Source:Eurekalert

Related medicine news :

1. Toxic mercury, accumulating in the Arctic, springs from a hidden source
2. Applied nanobiomedicine: Exploiting nanoparticles to hunt for hidden cancer cells
3. WSU study finds overwhelming evidence of hidden heart disease in hypertensive African-Americans
4. Bioinformatics experts at the CNIO explore additional coding potential hidden in the human genome
5. Cancer Drug May Flush Out Hidden HIV: Study
6. First study of eating disorders in teen ER patients suggests an opportunity to spot hidden problems
7. The hidden disorder: Unique treatment proposed for childrens neurological disorder
8. Hidden HPV May Reactivate in Older Women, Study Suggests
9. Hepatitis: The Hidden Hazard
10. Erectile Dysfunction May Signal Hidden Heart Disease
11. Caribbean Hideaways / Go Classy Tours Announces the Launch of Their Newest Website http://www.HiddenBeachMexico.com the Premier all Nude, Nudist Resort in Mexico
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/28/2016)... (PRWEB) , ... April 29, 2016 , ... Monthly subscription ... products on the market. They recently reviewed the ZEN BOX , the aromatherapy ... are two single essential oils (like lavender or frankincense) and one Zen Blend (like ...
(Date:4/28/2016)... ... April 28, 2016 , ... Sanford Health’s ... week. A group of researchers and leaders from Sanford Health were selected to ... and Its Cultural Impact ” and receive the 2016 Pontifical Key Innovation Award ...
(Date:4/28/2016)... ... 2016 , ... CastCoverz!, America’s #1 trusted brand for cast ... waterproof cast protector . As the largest one-stop, orthopedic shop, CastCoverz! offers ... night, weatherproof and waterproof covers for most orthopedic devices, including but not limited ...
(Date:4/28/2016)... ... April 28, 2016 , ... ... announces today the open availability of a new CDISC standard, Clinical Trial ... registering clinical trials. This innovative standard will make it possible to build ...
(Date:4/28/2016)... ... April 28, 2016 , ... Trinity Health, one of ... leading force in the fight to reduce tobacco use and its deadly toll, ... help reduce tobacco use. The initiative brings together two organizations committed to achieving ...
Breaking Medicine News(10 mins):
(Date:4/27/2016)... April 27, 2016 Oasmia ... developer of a new generation of drugs within ... survival results for Paclical/Apealea in the Phase III ... with epithelial ovarian cancer. These preliminary results showed ... combination with carboplatin versus Taxol in combination with ...
(Date:4/27/2016)... 2016 At the Sachs CEO ... a Phase 2 clinical study of its lead drug ... cochlear implantation (CI) surgery. This large, placebo-controlled, double-blind, phase ... Germany and France . ... the time of surgery. "Despite advances in cochlear implant ...
(Date:4/26/2016)... 26, 2016 US demand for infection ... 4.9 percent annually to $27.6 billion in 2020.  ... to decrease rates of healthcare-associated infections (HAIs) will ... and services.  Although declining, the overall rate of ... levels set by the CDC.  Recent statistics indicate ...
Breaking Medicine Technology: