BETHESDA, Md., Aug. 7 /PRNewswire-FirstCall/ -- Micromet, Inc. (Nasdaq: MITI), a biopharmaceutical company focusing on the development of novel, proprietary antibodies for the treatment of cancer, inflammation and autoimmune diseases, today announced its financial results for the second quarter and six months ended June 30, 2008.
Summary of Recent Events:
In June, Micromet and MedImmune presented a clinical update for the BiTE(R) antibody blinatumomab (MT103/MEDI-538) at the International Conference on Malignant Lymphoma in Lugano, Switzerland. All seven patients with relapsed non-Hodgkin's lymphoma treated with blinatumomab at the highest dose level presented at the conference responded to the treatment with partial or complete responses. Responses also appeared to be durable. The most frequent side effects observed so far were lymphopenia, pyrexia and leukopenia. Less common adverse events included transient neutropenia and thrombocytopenia, transient increase of liver enzymes and central nervous system events, all of which were fully reversible. In addition, Micromet and MedImmune commenced treatment of patients with acute lymphoblastic leukemia in a phase 2 clinical trial of blinatumomab.
Also in June, Micromet received a milestone payment of $775,000 from Nycomed in connection with the initiation of formal preclinical safety studies for antibody MT203, which has potential applications in the treatment of inflammatory and autoimmune diseases.
In April, Micromet announced the initiation of the first phase 1
clinical trial with its BiTE antibody MT110. The study will explore the
safety, pharmacokinetics, pharmacodynamics and anti-tumor activity of MT110
in patients with lung cancer and patients with gastrointestinal cancer.
MT110 targets the epithelial cell adhesion molecule (EpCAM or CD326), which
is highly expressed on colon, lung, breast, prostate, ovarian, gastric and
pancreatic cancer cells and on cancer stem cells of colon,
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