Navigation Links
Microgrid allows simultaneous study of multiple variables
Date:10/10/2007

UPTON, NY -- Scientists at the U.S. Department of Energy's Brookhaven National Laboratory have developed a method for correlating the results of microscopic imaging techniques in a way that could lead to improved understanding, diagnosis, and possibly treatment of a variety of disease conditions, including Alzheimer's disease. The Laboratory has filed a U.S. provisional patent application for the invention.

The invention is essentially a micron-scale metallic marking grid upon which scientists place their samples -- biological tissues or inorganic samples such as minerals -- prior to imaging with different methods. "When the findings are analyzed, the grid can be used to 'map,' or orient, the images to one another, allowing us to study multiple variables in a single sample and better understand how they relate to one another," said biophysicist Lisa Miller, leader of the team that developed the new method.

For example, many diseases such as Alzheimer's are characterized by changes in both organic materials, such as proteins, as well as changes in the composition or concentration of inorganic trace metals (e.g., iron, copper, and zinc). Scientists have techniques -- infrared spectroscopy and x-ray fluorescence -- for studying each of these independently. But without a way to correlate the findings from the two methods, important information about the relationship between the organic and inorganic components can be missed.

"The x-ray and infrared-sensitive grid allows for the study of both pathological symptoms by precisely overlapping the results of these imaging methods," Miller said. "This ability to correlate images will ultimately lead to a more complete picture of many disease states."

The grid is deposited in two thicknesses onto an x-ray transparent material like mylar. It can be made of any metal, but gold is preferred. The "bars" of the grid are only a couple of nanometers thick, whereas the remainder of the metal surface is thicker. The dual thicknesses make the pattern sensitive to both infrared reflectivity and x-ray fluorescence imaging.

In another version of the invention, a single-layered grid is used to correlate light microscopy with x-ray fluorescence imaging.

Once the images are collected, custom software uses the grid patterns to align the images and correlate them with each other.

In addition to helping scientists study disease processes, the method could also be applied in monitoring and/or cleaning up environmental contamination, which is also characterized by the interplay of organic and inorganic factors.


'/>"/>

Contact: Karen McNulty Walsh
kmcnulty@bnl.gov
631-344-8350
DOE/Brookhaven National Laboratory
Source:Eurekalert

Related medicine news :

1. FDA allows barley producers to make healthy heart claims
2. Woman swallows mobile phone - assault by boyfriend?
3. New policy allows Britons to decide on treatment center
4. U S Government Allows Non-prescription Diet Pill
5. Sanofi-Aventis Allows Thais To Make Plavix
6. British Court Allows Argument in Favour of Open-air Funerals
7. US Court Allows Teva to Deliver Disputed Drug: Novartis
8. Bush Administration Allows Returning Soldiers to Disintegrate, Say Critics
9. wake Up and Breathe Strategy Allows Patients to Come Off Ventilator Sooner
10. Tissue Engineered Scaffolding Allows Reproduction of Cartilage Tissue
11. Pride, Even the Hubristic Kind, Allows Us to Survive
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... ... June 27, 2016 , ... Quality metrics are proliferating in ... ways they remain in the eye of the beholder, according to experts who offered ... The American Journal of Managed Care. For the full issue, click here . ...
(Date:6/26/2016)... (PRWEB) , ... June 26, 2016 , ... PawPaws ... a new product that was developed to enhance the health of felines. The formula ... , The two main herbs in the PawPaws Cat Kidney Support Supplement ...
(Date:6/25/2016)... ... June 25, 2016 , ... ... and applications at AcademyHealth’s Annual Research Meeting June 26-28, 2016, at the Hynes ... important health care topics including advance care planning, healthcare costs and patient and ...
(Date:6/25/2016)... , ... June 25, 2016 , ... "With 30 hand-drawn ... specific project," said Christina Austin - CEO of Pixel Film Studios. , ProHand ... all within Final Cut Pro X . Simply select a ProHand generator and ...
(Date:6/25/2016)... ... June 25, 2016 , ... Dr. Calvin Johnson has ... he has implemented orthobiologic procedures as a method for treating his patients. The ... first doctors to perform the treatment. Orthobiologics are substances that orthopaedic surgeons use ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... Dehaier Medical Systems Ltd. (NASDAQ: DHRM ) ... medical devices and wearable sleep respiratory products in ... with Hongyuan Supply Chain Management Co., Ltd. (hereinafter referred ... to develop Dehaier,s new Internet medical technology business. ... Hongyuan Supply Chain,s sales platform to reach Dehaier,s dealers ...
(Date:6/24/2016)... Belgium , June 24, 2016 ... the appointment of Dr. Edward Futcher ... Non-Executive Director, effective June 23, 2016.Dr. Futcher was ... Nominations and Governance Committees.  As a non-executive member ... independent expertise and strategic counsel to VolitionRx in ...
(Date:6/23/2016)... , June 23, 2016 ... "Pharmaceutical Excipients Market by Type (Organic Chemical (Sugar, ... Formulation (Oral, Topical, Coating, Parenteral) - Global Forecast to ... The global pharmaceutical excipients market ... at a CAGR of 6.1% in the forecast period ...
Breaking Medicine Technology: