Navigation Links
Microfluidic technology reveals potential biomarker for early pancreatic cancer
Date:4/29/2014

ANN ARBOR, Mich. Cancer cells are on the move in the bloodstream in the very early stage of pancreatic cancer, and can be detected before cancer is diagnosed, according to research by the University of Michigan Health System.

In a study of 51 patients, researchers used a state-of-the art microfluidic device to capture circulating pancreas epithelial cells in 33 percent of patients with early pancreatic lesions and no clinical diagnosis of cancer.

The findings, published in Gastroenterology, suggest that circulating pancreas cells (CPCs) seed the bloodstream before tumors can be detected using current clinical tests such as CT and MRI scans. The data suggest that the detection of pancreas cells in the blood may be an early sign of cancer.

"While there is much work that still needs to be done, there is great potential for using this technology to identify who is most at risk for developing pancreatic cancer," says lead author Andrew Rhim, M.D., an assistant professor of internal medicine at the U-M Health System and gastroenterologist at the U-M Comprehensive Cancer Center's Multidisciplinary Pancreatic Cancer Clinic.

One reason the outlook for pancreatic cancer is poor is that very few of the cancers are found early. Patients usually have no symptoms until the cancer has spread to other organs. There are no blood tests to find early cancers of the pancreas.

It is thought that cancer cells seed the bloodstream late in cancer progression, when large tumors are present. But based on studies in animal models of pancreatic cancer, U-M researchers and colleagues theorized that dissemination happens before we tumors can be detected.

They studied three groups of patients: those who were cancer-free, those diagnosed with precancerous cystic lesions, and patients with pancreatic cancer. Researchers captured circulating epithelial cells in 73 percent of patients with cancer. None of the 19 cancer-free patients without lesions had these cells in their bloodstream.

"Studies are underway to interrogate the genomic signature of circulating pancreas cells from patients with precancerous cystic lesions," says Rhim.

"If these cells represent the earliest forms of cancer, we predict they would possess many of the genetic anomalies we typically see in pancreas tumors."


'/>"/>

Contact: Shantell M. Kirkendoll
smkirk@umich.edu
734-764-2220
University of Michigan Health System
Source:Eurekalert  

Related medicine news :

1. Microfluidics Market to Grow at a CAGR of 17.6% to 2018 Forecasts in New Research Report at RnRMarketResearch.com
2. Microfluidics Market Worth $3.5 Billion by 2018
3. Mechanical tissue resuscitation technology shows promise
4. New study identifies how information technology is used to solve global health challenges
5. Power generation technology based on piezoelectric nanocomposite materials developed by KAIST
6. Simulation technology allows users to safely practice phacoemulsification cataract surgery
7. The Casey Group's Sales Navigator Wins 2012 Best Mobility App in the New Jersey Technology Council's Mobile Application Competition
8. Swanson Health Products Introduces a New Alkalizing Drink Mix, Swanson® pH Balance Alka-Tone with Alka-Plex™ Technology
9. Miami Children’s Hospital Performs First Nerve Repair Surgery Using Avance® Nerve Graft Technology
10. FDA Approves SonixGPS Needle Guidance Technology for Vascular Access Procedures
11. IVR Technology Group Named Platimum VAR by TSYS
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Microfluidic technology reveals potential biomarker for early pancreatic cancer
(Date:2/8/2016)... , ... February 08, 2016 , ... ... in Houma, LA, celebrates the beginning of a new charity campaign. As part ... Court Appointed Special Advocates (CASA). In the belief that children deserve a voice, ...
(Date:2/8/2016)... (PRWEB) , ... February 08, 2016 , ... ... BantamPro L top-load case packer for pouches, bags, and flow wrapped products at ... help co-packers and specialty product manufacturers step up to semi-automatic or fully-automatic case ...
(Date:2/8/2016)... Island, SC (PRWEB) , ... February 08, 2016 , ... ... surrounding areas with a vital new community enrichment program, has teamed up with Citizens ... women and children suffering from intimate abuse. To support all those victimized by the ...
(Date:2/8/2016)... CA (PRWEB) , ... February 08, 2016 , ... Delta ... $792,000 to help combat pancreatic cancer. , Gary D. Radine, who recently retired as ... was the American Cancer Society’s 2015 CEO of the Year , helped lead ...
(Date:2/8/2016)... ... February 08, 2016 , ... Eating disorders and ... number of women and men with eating disorders report a history of trauma, ... the development of an eating disorder. , At the 2016 iaedp Symposium, ...
Breaking Medicine News(10 mins):
(Date:2/8/2016)... 8, 2016 --> ... report "Ablation Technologies Market by Product (Radiofrequency, Ultrasound, Irreversible ... Cosmetic Surgery, Ophthalmology, Gynecology) - Global Forecasts to 2020", ... over the forecast period of 2015 to 2020. The ... at CAGR of 10.5% from 2015 to 2020. ...
(Date:2/8/2016)... , Feb. 8, 2016 ... that formerly specialized in the development of ... announced that it has divided its interests ... While Nueterra Capital will continue the founding ... NueHealth will operate a national system of ...
(Date:2/8/2016)... Feb. 8, 2016  A research team led by ... discovered details of how the abnormal breakage and rearrangement ... aggressive form of acute lymphoblastic leukemia (ALL). Such leukemias ... mutations trigger overproduction of immature cells, called lymphoblasts. ... of the malfunction underlying the type called "Ph-like ALL" ...
Breaking Medicine Technology: