Navigation Links
Microchip Spots Cancerous Tumors Within an Hour, Study Shows
Date:2/23/2011

By Maureen Salamon
HealthDay Reporter

WEDNESDAY, Feb. 23 (HealthDay News) -- Scientists say they have developed a microchip that can be attached to a smart phone and diagnose cancerous tumors within an hour, from the patient's bedside.

The so-called microNMR chip, which uses magnetic nanoparticles to measure proteins and other chemical compounds in tumors, requires only tiny amounts of tissue to make a diagnosis, researchers said. Instead of more invasive methods, the biopsy can be done with fine needle aspiration, which withdraws cells from suspicious lesions.

"We tried to determine a molecular fingerprint, if you will," said study co-author Jered B. Haun, a postdoctoral researcher at Massachusetts General Hospital in Boston. "It was a nice surprise just how well it worked with all the protein markers. One of our big goals was not only to be able to tell patients they have cancer as accurately as possible, but as quickly as possible."

The study, which was funded by grants from the U.S. National Institutes of Health, is published in the Feb. 23 issue of the journal Science Translational Medicine.

Using the microchip -- which can be hooked up to smart phones such as iPhones and Blackberrys -- researchers analyzed tissue samples from 50 patients with suspected malignancies, correctly diagnosing cancer in 44 patients within 60 minutes in 96 percent of cases by zoning in on four of nine protein markers.

In contrast, standard pathology methods typically require three or more days to produce a diagnosis and are only 84 percent accurate, the researchers noted.

Study participants, whose average age was 64, had suspicious lesions in a variety of organs, including the lungs, colon, pancreas, liver and breasts, and were already scheduled to receive biopsies for abnormal stomach tissue. Their results were validated with traditional pathology -- which also didn't assess differences in tumor cell types as well as the microchip -- along with an independent group of 20 additional patients, Haun said. The microchip diagnoses in the additional group were 100 percent accurate, according to the study.

"False negatives and non-diagnostic samples are both at higher incidence with standard pathology," Huan said. "Since the [microchip-tested] sample size is so small, we take small aspirants of different areas of the tumor ... to get a more global view of the results," which can also impact treatment requirements.

Huan and the other study authors reported no financial conflicts of interest.

Dr. Moritz Kircher, a diagnostic radiologist at Memorial Sloan-Kettering Cancer Center in New York City, said he envisions the microchip eventually being used to diagnose an array of malignancies, both internal and external.

"I see it more as a universal method because it relies on biological markers," said Kircher, also an assistant professor of radiology at Weill Cornell Medical College. "This is basically the first time they've used this in a clinical study and the results are very promising."

Haun and Kircher agreed more research would be needed before the microchip technology could be used routinely and that greater numbers of patients with more types of possible malignancies should be studied. Haun said he also hopes the microchip will one day be able to analyze blood samples to minimize invasive procedures.

Once marketed, the tool should be inexpensive to produce, Haun noted, possibly only dollars per chip.

"Like cell phones in general, the more you make, the cheaper they get," he said. "It's not an expensive device at all."

With the data at hand, however, it should be easy to convince potential investors to put the necessary cash into promoting the technology, said Dr. Jan Grimm, a nanotechnology researcher and radiologist at Memorial Sloan-Kettering Cancer Center.

"When they can claim a better result than [traditional diagnostic methods], that's pretty amazing," Grimm said. "It's better than pathology, which is considered the gold standard."

More information

For more on cancer pathology, visit the National Cancer Institute.

SOURCES: Jered B. Haun, Ph.D., postdoctoral researcher, Massachusetts General Hospital, Boston; Moritz Kircher, M.D., Ph.D., diagnostic radiologist, Memorial Sloan-Kettering Cancer Center, New York City, and assistant professor, radiology, Weill Cornell Medical College; Jan Grimm, M.D., Ph.D., radiologist, Memorial Sloan-Kettering Cancer Center, New York City; Feb. 23, 2011, Science Translational Medicine


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Scientists Aim for Test That Spots Single Cancer Cell in Blood Sample
2. Leopard Spots, Tiger Stripes Aid Camouflage, Study Finds
3. Finding cancer cold spots can help minimize radiotherapy side-effects
4. Test Spots Potential Organ Donors Among Coma Patients
5. Science Reveals Secrets of Animals Spots, Stripes
6. New Polycarbonate Sign Face Material Eliminates Hot Spots, Optimizes Light Uniformity in LED Back-Lit Signs
7. Pre-Season Test Spots Baseball Pitchers at Risk of Injury
8. A double block of blood vessels to starve cancerous tumors
9. Combined imaging technologies may better identify cancerous breast lesions
10. Prostate cancer patients are at increased risk of precancerous colon polyps
11. Gene identified that prevents stem cells from turning cancerous
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Microchip Spots Cancerous Tumors Within an Hour, Study Shows
(Date:3/28/2017)... ... 2017 , ... Resoundant, Inc., the developer of Magnetic ... annual customer education symposium, a world-class learning conference that offers educational content designed ... 31, 2017 at the Atlanta Marriott Marquis in Atlanta, Georgia. , Innovations for ...
(Date:3/28/2017)... ... March 28, 2017 , ... ... of all holidays (IBT World Travel Trends Report). As travelers visit both urban ... range in temperatures, and prolonged sun exposure. In response, the outdoor industry has ...
(Date:3/28/2017)... ... ... Alert Sentry Group LLC., a leader in the Personal Emergency Response System industry, introduced ... Plus. These iSAFE products are the most affordable and most advanced medical alert systems ... direct GPS Location and two-way calling with the push of a button on a ...
(Date:3/28/2017)... ... , ... The Radiology Business Management Association (RBMA) is pleased to ... executive director. Mr. Still was selected through a careful months-long search by the RBMA ... known to our members, has been a part of building the RBMA since 1992,” ...
(Date:3/28/2017)... ... March 28, 2017 , ... Neurotechnology , a provider ... and attendance tracking products: the new NCheck Cloud Bio Attendance cloud-based service and ... biometric face recognition to enable users to check in and out from anywhere ...
Breaking Medicine News(10 mins):
(Date:3/28/2017)... TEL AVIV, Israel , March 28, 2017 ... . This new business entity, Emosis Ltd, headquartered in ... and development of novel assays complementing the mother company existing technology ... support commercialization and sales development of Emosis kits. ... This strategic move starts building Emosis ...
(Date:3/28/2017)... Mass. , March 28, 2017 ... company developing innovative therapeutics that address significant unmet ... a patent from the Japan Patent Office (JPO) ... connective tissue growth factor (CTGF) for the treatment ... limited to skin fibrosis and proliferative retinopathy (Japanese ...
(Date:3/28/2017)... Elysium Health joins major pharmaceutical companies to ... Cambridge academic scientists through ... Institute today announces Elysium Health as a partner to the ... collaborative projects with academic researchers in Cambridge ... major research investment outside the U.S. for the ...
Breaking Medicine Technology: