Navigation Links
Microbubbles improve myocardial remodelling after infarction
Date:2/21/2013

Scientists from the Bonn University Hospital successfully tested a method in mice allowing the morphological and functional sequelae of a myocardial infarction to be reduced. Tiny gas bubbles are made to oscillate within the heart via focused ultrasound - this improves microcirculation and decreases the size of the scar tissue. The results show that the mice, following myocardial infarction, have improved cardiac output as a result of this method, as compared to untreated animals. The study is now being presented in the professional journal PLOS ONE.

Every year in Germany, approximately 280,000 people suffer a myocardial infarction; more than 52,000 die as a result. Due to an occluded vessel, parts of the heart muscle no longer have sufficient circulation and the tissue dies off. These regions are not replaced by new heart muscle cells but instead by scar tissue this generally causes the pump function of the heart to decrease following an infarction. Scientists from the Bonn University Hospital have now successfully tested a new method on mice with which scar tissue can be reduced and cardiac output increased.

Microbubbles are made to oscillate within the heart

"There are attempts to treat the scar tissue with gene therapy or stem cells - by contrast, we have chosen a physical approach to treatment," reports Adj. Professor Dr. med. Alexander Ghanem from the Department of Cardiology of the Bonn University Hospital. The researchers injected a total of 17 mice which had previously had a myocardial infarction with microscopically small, gas-filled bubbles in the bloodstream. Once the microbubbles reached the heart, they were made to vibrate there using focused ultrasound. "Through this mechanical stimulation, the circulation of the area of the infarction is improved - and the scar shrinks," says the cardiac specialist.

Treated animals demonstrate ameliorated post-infarction remodelling

The scientists compared the results of the mice treated with the microbubbles to those of a control group. Two weeks after the myocardial infarction, there was expected worsening of heart function in the control group due to the maturing of the scar tissue. In contrast, the mice treated with the microbubbles did not develop any cardiac insufficiency. Jonas Drner, the first author of the study, summarizes the results: "The pumping function was significantly better in the treated animals as compared to the control group; there was also a significantly smaller amount of decayed heart muscle tissue." Along with the Department of Cardiology, the Departments of Cardiac Surgery and Anesthesiology and the Institute of Physiology took part in the investigations.

Ultrasound treatment stimulates growth hormones

The scientists sought the causes of the positive treatment success which is, however, unexplained to date. Following ultrasound treatment of the mice, it was demonstrated that the amount of the body's own growth hormones significantly increased in the heart. "This is evidently the reason why the scar formation decreased as a result of the oscillating microbubbles," says Dr. Ghanem. The scientists now hope that humans will also be able to eventually be treated with the microbubble-ultrasound method, however further investigations are still needed. "Potentially, all patients who have had an acute myocardial infarction are eligible for this follow-up treatment," explains the cardiologist of the Bonn University Hospital. Interestingly, microbubbles are already used as a diagnostic contrast agent.

Patent for novel ultrasound method filed

The study, conducted with support from the BONFOR funding program of the Medical Faculty of Bonn University and the German Heart Foundation [Deutsche Herzstiftung e.V.], gave rise to a patent application. "Together with the company Philips Medical, we developed a novel ultrasonic probe which enables a standardized impulse discharge in the heart," reports the cardiologist. The special feature is that two ultrasound sources linked together are contained in one hybrid ultrasonic probe: one with low frequency for the focused stimulation of the microbubbles in the target organ and one with higher frequency for imaging. In this way, it can be very precisely determined where the scar tissue and the microbubbles are located. "This study demonstrates again that university research inspires technological developments in medicine," says Dr. Ghanem.


'/>"/>

Contact: Alexander Ghanem
ghanem@uni-bonn.de
49-228-287-15507
University of Bonn
Source:Eurekalert

Related medicine news :

1. Clinical insight improves treatment with new lung cancer drug
2. Improved Stem Cell Line May Avoid Tumor Risk: Study
3. Normalizing tumor blood vessels improves delivery of only the smallest nanomedicines
4. Exercise improves quality of life during breast cancer treatment
5. IU, Regenstrief automated system aims to improve child health
6. Swallowing exercises linked with short-term improvement among patients with head and neck cancer
7. MU receives national award for using mind-body approach to improve health
8. Feelings of immaturity accompany alcohol misuse into adulthood; discovery could improve treatments
9. Awards celebrate clinical research that can improve health and alleviate suffering
10. Naturopathic care can improve blood sugar, mood in diabetes
11. Early treatment improves outcomes in rare, often undiagnosed form of encephalitis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/20/2017)... ... July 20, 2017 , ... Remote ... which their iMedSecure™ comes included with each system installation. RMT’s iMedHD2™ ... remote participants for real-time collaboration and immediate decision-making requirements. While never sharing ...
(Date:7/20/2017)... , ... July 20, 2017 , ... ... **An FDAnews Webinar**, Aug. 9, 2017 — 1:30 p.m. – 3:00 p.m. ET, ... passing inspections and boosting quality. , It’s known as the “CY2016 Annual FDA ...
(Date:7/20/2017)... ... July 20, 2017 , ... With nearly half of all ... solution company VisitorsCoverage Inc. has launched TMQuotes, a new cloud-based solution platform which ... online, under their own brand. The online marketplace bridges the technological gap in ...
(Date:7/20/2017)... ... July 19, 2017 , ... At Creekwood Dental Arts, Drs. Donna G. ... treatment and dental implants in Waco, TX, using the latest dental technology ... by Tekscan®, they can capture details in the oral cavity for accurate diagnoses and ...
(Date:7/20/2017)... Washington (PRWEB) , ... July 19, 2017 , ... ... 11 “surprising habits” that may sometimes lead to, or worsen, varicose veins in ... Aesthetic Center notes that, while avoiding certain not-so-good practices, like excessive sitting or ...
Breaking Medicine News(10 mins):
(Date:7/12/2017)... 2017  Eli Lilly and Company (NYSE: LLY ... to resolve pending patent litigation in the U.S. District Court ... regarding the Cialis ® (tadalafil) unit dose patent. This ... As part of the agreement, Cialis exclusivity is now expected ... "The unit dose patent for Cialis is valid and ...
(Date:7/11/2017)... 2017  Bayer has awarded grants totaling more than $2 ... its prestigious Bayer Hemophilia Awards Program (BHAP). Four U.S. clinicians ... and Uniformed Services University of the Health Sciences ... Grant recipients were announced last night during a reception at ... Berlin, Germany . ...
(Date:7/11/2017)... , July 11, 2017  Sysmex America, ... urinalysis diagnostic testing equipment as well as middleware ... a way to make quality assurance easier and ... "Sysmex is well known for the innovation that ... Quality Monitor elevates quality assurance processes to a ...
Breaking Medicine Technology: