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Microbiotic technology developed for microinjection of zebrafish embryos
Date:9/12/2007

Funded by an NSERC Idea to Innovations grant and an Ontario Early Researcher Award, Prof. Yu Suns group, the Advanced Micro and Nanosystems Laboratory (http://amnl.mie.utoronto.ca) at the University of Toronto (U of T) recently developed a microrobotic technology for automated microinjection of zebrafish embryos.

Based on computer vision and motion control, the automated microrobotic system is capable of immobilizing a large number of zebrafish embryos into a regular pattern within seconds and injecting 15 embryos (chorion unremoved) per minute with a success rate, survival rate, and phenotypic rate all close to 100%. The system and performance were reported in the journal PLoS ONE in an article entitled, A Fully Automated Robotic System for Microinjection of Zebrafish Embryos.

Zebrafish is a model organism widely used in life sciences. High-speed injection of zebrafish embryos is important for screening genes in genetics and drug molecules in drug discovery. The automated microrobotic system proves itself as a reliable tool for determining gene functions and more generally, for facilitating large-scale molecule screening.


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Contact: Yu Sun
sun@mie.utoronto.ca
Public Library of Science
Source:Eurekalert

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