Navigation Links
Microbiology and Genome Experts Quell Deadly Bacteria Outbreak
Date:8/22/2012

WEDNESDAY, Aug. 22 (HealthDay News) -- A deadly outbreak of antibiotic-resistant bacteria at a U.S. research hospital lasted six months and was finally brought under control through the combined efforts of genomics and microbiology experts, government researchers report.

The outbreak began when a 43-year-old New York City patient carrying a multi-drug resistant strain of Klebsiella pneumoniae introduced the dangerous bacteria into the 243-bed U.S. National Institutes of Health's Clinical Center in Bethesda, Md., in June 2011. The microbe is a common cause of hospital-borne infections.

Even with enhanced infection-control procedures, including patient isolation, the bacteria began to spread to other patients in the facility at the rate of one a week. The bacteria eventually affected 17 patients. Ten of these patients died; six from infection and four from underlying diseases while infected.

Clinical Center staff worked with investigators at the U.S. National Human Genome Research Institute (NHGRI) to use genome sequencing to learn how the microbe spread. That collaboration helped bring the outbreak under control by the end of the year. Since then, there have been no new cases associated with the outbreak.

"Infectious outbreaks happen in every hospital in the world, afflicting millions of patients each year in the United States alone," NHGRI director Dr. Eric Green, said in an NIH/NHGRI news release.

"By marshaling the ability to sequence bacterial genomes in real time to accurately trace the bacteria as it spread among our Clinical Center patients, our researchers successfully elucidated what happened, which in turn has taught us some important lessons," he explained. "This study gives us a glimpse of how genomic technologies will alter our approach to microbial epidemics in the future."

A case history of the outbreak was published online Aug. 22 in the journal Science Translational Medicine.

"Genome sequencing and analysis is our best hope for anticipating and outpacing the pathogenic evolution of infectious agents," Julie Segre, an NHGRI senior investigator involved in the outbreak, said in the news release. "Though our practice of genomics did not change the way patients were treated in this outbreak, it did change the way the hospital practiced infection control."

About 1.7 million hospital-associated infections, and 99,000 related deaths, occur each year in the United States, according to the U.S. Centers for Disease Control and Prevention. Multi-drug resistant K. pneumoniae is among the more dangerous infections because there are few effective treatments and the death rate can be as high as 50 percent, the researchers pointed out in the news release.

They also noted that multi-drug resistant K. pneumoniae -- which is an increasing problem in health-care facilities -- is most dangerous for patients with immune systems weakened by medical procedures or by conditions such as advanced age and illness.

In another case, which was described in a report in the June 21 issue of the Morbidity and Mortality Weekly Report, published by the CDC, swift treatment and infection control measures prevented the spread of rare but deadly New Delhi metallo-beta-lactamase-producing K. pneumoniae that was found in two patients in a Rhode Island hospital in 2011.

Commenting on that report, lead researcher Dr. Leonard Mermel, medical director of the department of epidemiology and infection control at Rhode Island Hospital in Providence, said: "These people had the bacteria in their body, but fortunately it was not causing an infection anywhere."

More information

The U.S. Centers for Disease Control and Prevention has more about health care-associated infections.

-- Robert Preidt

SOURCE: U.S. National Institutes of Health/U.S. National Human Genome Research Institute, news release, Aug. 22, 2012


'/>"/>
Copyright©2012 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. NIH uses genome sequencing to help quell bacterial outbreak in Clinical Center
2. Mayo Clinic completes first genome-wide analysis of peripheral T-cell lymphomas
3. Genome analysis of brain tumors showing the way to new treatment strategies
4. Scientists Map Genomes of One Mans Sperm
5. New Stanford method enables sequencing of fetal genomes using only maternal blood sample
6. Genome-wide analysis shows previously undetected abnormalities in parents of affected children
7. Bioinformatics experts at the CNIO explore additional coding potential hidden in the human genome
8. Bonobo Genome Sheds Light on Their Links to Chimps, Humans
9. Entire Genome of Human Fetus Deciphered
10. Scientists Map the Tomatos Genome
11. Genomes show how Staph bacteria gain resistance to last-line drug
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Microbiology and Genome Experts Quell Deadly Bacteria Outbreak
(Date:5/5/2016)... ... May 05, 2016 , ... TIME for Kids and The ... announced a new partnership to reach nearly 1 million children with important water safety ... and is the leading cause of accidental death in children one to 6 years ...
(Date:5/5/2016)... Woodinville, WA (PRWEB) , ... May 05, 2016 ... ... better user experience, adapted to people’s every day living patterns, Amerec, a Seattle-based ... easy-to-use computer and smart phone app. , The user interface of the app, ...
(Date:5/5/2016)... ... (PRWEB) May 05, 2016 , ... Talent Tech Labs ... on the eve of National Nurses Week (May 6-12). Currently, HireNurses is ... With their enrollment into the Talent Tech Lab Virtual Incubation program, they will dramatically ...
(Date:5/5/2016)... ... 2016 , ... Chronic stress can have a silent, yet dangerous, impact on ... system and increase inflammation, both of which raise the risk of heart attack and ... program at Harvard-affiliated Massachusetts General Hospital. Chronic stress also can lead to other issues ...
(Date:5/5/2016)... ... May 05, 2016 , ... ... finalists and winners Tuesday evening, May 3, at the 2016 ISE® Central Executive ... Scott Pettigrew, Vice President and Chief Security Officer of HMS, was selected as ...
Breaking Medicine News(10 mins):
(Date:5/4/2016)... , May 4, 2016 ... of the  "Global Multiple Myeloma Market and ... their offering.       (Logo: ... Market and Competitive Landscape Highlights 2016, provides ... Multiple Myeloma epidemiology, Multiple Myeloma market valuations ...
(Date:5/4/2016)... Research and Markets has ... Myeloid Leukemia Market and Competitive Landscape Highlights ...      (Logo: http://photos.prnewswire.com/prnh/20160330/349511LOGO ) ... Competitive Landscape Highlights 2016, provides comprehensive insights ... Myeloid Leukemia epidemiology, Acute Myeloid Leukemia market ...
(Date:5/4/2016)... 2016 Research and ... Acute lymphocytic Leukemia Market and Competitive Landscape ...      (Logo: http://photos.prnewswire.com/prnh/20160330/349511LOGO ... Market and Competitive Landscape Highlights 2016, provides ... products, Acute Lymphocytic Leukemia epidemiology, Acute Lymphocytic ...
Breaking Medicine Technology: