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Microarray provides 3 genomic guides to breast cancer treatment decisions
Date:9/7/2007

for five years. The index did not predict prognosis among 507 patients who did not receive hormone therapy. "We believe this is the first genomic test to predict sensitivity to hormone therapy independent of a patient's prognosis if no post-surgical treatment is received," Symmans says.

"A patient with ER-positive breast cancer probably still would choose to receive hormonal therapy, but better understanding of their cancer's sensitivity to endocrine therapy would help patients and their doctors decide on a treatment strategy," Symmans notes.

Pusztai will present a poster showing what the three predictors reported in two groups of breast cancer patients. "These three predictors were developed and validated separately, now we've put them together for the intended purpose - to provide all the necessary information for physicians and patients to decide on the best therapy or combination of therapies for breast cancer from a single assay," Pusztai says.

The 3 clinical outcome predictors are;

  • A 76-gene prognostic test that indicates whether a patient is at high or low risk of the cancer recurring after surgery developed by investigators at Erasmus University (Rotterdam, Netherlands) and Veridex LLC.
  • A 30-gene predictor of the cancer's sensitivity to chemotherapy developed by M.D. Anderson investigators.
  • The 200-gene index (SET) of sensitivity to hormone (endocrine) therapy developed by M.D. Anderson in collaboration with Nuvera Biosciences Inc.

The ASCO poster describes gene expression profiles analyzed from 198 patients with stage 1 or stage 2 breast cancer that had not spread to the lymph nodes and who had not been given chemotherapy or endocrine therapy after surgery.

Among the 198 patients, 55 were predicted to be at relatively low risk that the cancer would return. Of those low-risk patients, 21 were predicted to have cancer vulnerable to chemotherapy and 16 were predicted to have tumors su
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Contact: Scott Merville
sdmervil@mdanderson.org
713-792-0661
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert

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