Navigation Links
MicroRNAs make for safer cancer treatments
Date:10/26/2008

ROCHESTER, Minn. -- Viruses -- long regarded solely as disease agents -- now are being used in therapies for cancer. Concerns over the safety of these so-called oncolytic viruses stem from their potential to damage healthy tissues. Now Mayo Clinic researchers have discovered a way of controlling the viruses behind potential cancer therapeutics. They are engineering the virus's genetic sequence, using microRNAs to restrict them to specific tissues. The microRNAs destabilize the virus's genome, making it impossible for the virus to run amok. The discovery is reported in the current issue of Nature Medicine.

"Our findings demonstrate a new tool for molecular medicine that should also help allay concern over the use of viruses as a therapeutic delivery system," says Stephen Russell, M.D., Ph.D., Mayo physician-scientist and lead author of the study.

MicroRNAs are the nucleotide snippets that are encoded by genes, but don't end up as proteins. In many cases, they have a role in down-regulating different cellular genes. In this case, a virus is engineered to be responsive to microRNAs that are present in certain cell types. Using this new form of targeting, researchers redirected a virus normally responsible for a lethal muscle infection to recognize only cancer cells. The laboratory mice that received the engineered virus were cured of established tumors and suffered no ill effects.

Significance of the research

Most viruses can infect different cell types, which leads to the array of symptoms during a viral infection. Now as viruses are being engineered for use as vaccines, cancer therapeutics and gene therapy vectors, researchers want to restrict and redirect the types of cells they do (or don't) infect as additional safeguards against disease. The target sequences of microRNAs used in the study kept the virus from destroying muscle cells while allowing viral replication to proceed in cancer cells allowing the virus to completely cure mice with melanoma.

The Mayo researchers say microRNA target insertion may be a new way to make viruses safer for use in cancer therapy and could lead to new methods of making safer vaccines.


'/>"/>

Contact: Robert Nellis
newsbureau@mayo.edu
507-284-5005
Mayo Clinic
Source:Eurekalert

Related medicine news :

1. MicroRNAs may be key to HIVs ability to hide, evade drugs, Jefferson scientists find
2. 2 microRNAs promote spread of tumor cells
3. MicroRNAs May Predict Colon Cancer Prognosis
4. Replacing absent microRNAs could make tumors less invasive, more treatable
5. MicroRNAs, EMT and cancer progression
6. MicroRNAs appear essential for retinal health
7. Putting microRNAs on the stem cell map
8. Small Incisions Make Heart Valve Surgery Safer
9. AUDIO from Medialink and Pfizer: Prescription for Safer Drugs Discussed in Washington
10. AUDIO from Medialink and Pfizer: A New Prescription for Safer Drugs
11. Safer, Simpler, Better & Cost Effective Cosmetic Surgery Anesthesia
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2017)... ... 26, 2017 , ... Antoine Dental Center is now offering various types of dental ... act as a support for prosthetic teeth, such as crowns, bridges, or dentures. An implant ... a sturdy, lasting new root for the tooth. , Several types of dental implants ...
(Date:6/26/2017)... ... June 26, 2017 , ... ... is revolutionizing the way women look and feel about themselves and their sexual ... female sexual dysfunction and urinary leakage head on with a ground breaking medical ...
(Date:6/26/2017)... ... ... New patients with missing teeth in Fitchburg, WI, can now receive ... is a trusted dentist who has placed many dental implants and enjoys teaching patients ... in Fitchburg, WI, are encouraged to find out if they are candidates for dental ...
(Date:6/25/2017)... Santa Rosa, CA (PRWEB) , ... June 25, 2017 , ... ... lot more green and growing foliage and plants, and along with that; a humdinger ... pollen sensitive allergy sufferers, it also means an increase in misery-causing grass and weed ...
(Date:6/24/2017)... ... June 24, 2017 , ... Genes Advice, ... medications in select Florida and Texas doctors' offices and clinics. This breakthrough testing ... of genetic testing recognizes the role genes play in determining an individual's tolerance ...
Breaking Medicine News(10 mins):
(Date:5/30/2017)... 2017 Therapix Biosciences Ltd. (Nasdaq: TRPX), ... the development of cannabinoid-based drugs, today announced that ... at three upcoming scientific and investor conferences in ... Invitational: ...                     Wednesday, June ...
(Date:5/24/2017)... HAMPTON, Va. , May 24, 2017 /PRNewswire/ ... ivWatch Original Equipment Manufacturer (OEM) Board to enable ... technology with patient monitoring systems, infusion pumps and ... products, OEMs will be able to help health ... care and reduced risks related to IV therapy. ...
(Date:5/18/2017)... , May 18, 2017  Two Bayer U.S. ... Association (HBA) during its recent 28 th ... City.  The event showcases HBA,s longstanding mission of furthering ... of healthcare. Cindy Powell-Steffen , senior ... U.S. Radiology division, and Libby Howe , a ...
Breaking Medicine Technology: