Navigation Links
MicroRNAs make for safer cancer treatments
Date:10/26/2008

ROCHESTER, Minn. -- Viruses -- long regarded solely as disease agents -- now are being used in therapies for cancer. Concerns over the safety of these so-called oncolytic viruses stem from their potential to damage healthy tissues. Now Mayo Clinic researchers have discovered a way of controlling the viruses behind potential cancer therapeutics. They are engineering the virus's genetic sequence, using microRNAs to restrict them to specific tissues. The microRNAs destabilize the virus's genome, making it impossible for the virus to run amok. The discovery is reported in the current issue of Nature Medicine.

"Our findings demonstrate a new tool for molecular medicine that should also help allay concern over the use of viruses as a therapeutic delivery system," says Stephen Russell, M.D., Ph.D., Mayo physician-scientist and lead author of the study.

MicroRNAs are the nucleotide snippets that are encoded by genes, but don't end up as proteins. In many cases, they have a role in down-regulating different cellular genes. In this case, a virus is engineered to be responsive to microRNAs that are present in certain cell types. Using this new form of targeting, researchers redirected a virus normally responsible for a lethal muscle infection to recognize only cancer cells. The laboratory mice that received the engineered virus were cured of established tumors and suffered no ill effects.

Significance of the research

Most viruses can infect different cell types, which leads to the array of symptoms during a viral infection. Now as viruses are being engineered for use as vaccines, cancer therapeutics and gene therapy vectors, researchers want to restrict and redirect the types of cells they do (or don't) infect as additional safeguards against disease. The target sequences of microRNAs used in the study kept the virus from destroying muscle cells while allowing viral replication to proceed in cancer cells allowing the virus to completely cure mice with melanoma.

The Mayo researchers say microRNA target insertion may be a new way to make viruses safer for use in cancer therapy and could lead to new methods of making safer vaccines.


'/>"/>

Contact: Robert Nellis
newsbureau@mayo.edu
507-284-5005
Mayo Clinic
Source:Eurekalert

Related medicine news :

1. MicroRNAs may be key to HIVs ability to hide, evade drugs, Jefferson scientists find
2. 2 microRNAs promote spread of tumor cells
3. MicroRNAs May Predict Colon Cancer Prognosis
4. Replacing absent microRNAs could make tumors less invasive, more treatable
5. MicroRNAs, EMT and cancer progression
6. MicroRNAs appear essential for retinal health
7. Putting microRNAs on the stem cell map
8. Small Incisions Make Heart Valve Surgery Safer
9. AUDIO from Medialink and Pfizer: Prescription for Safer Drugs Discussed in Washington
10. AUDIO from Medialink and Pfizer: A New Prescription for Safer Drugs
11. Safer, Simpler, Better & Cost Effective Cosmetic Surgery Anesthesia
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/27/2016)... Columbia, SC (PRWEB) , ... May 27, 2016 , ... ... launched a line of classic American timber frame barn kits, which can be found ... are inspired by historic American barn plans, and they highlight the craftsmanship of ...
(Date:5/27/2016)... ... May 27, 2016 , ... With over 60 percent of acute ... for a sustainable product to aid in the rehabilitation process has steadily increased. Ekso ... of individuals with hemiplegia due to stroke. , Ekso Bionics has now received clearance ...
(Date:5/27/2016)... ... ... Beleza Medspa has initiated a new program to assist active duty ... that Coolsculpting is being used for for more than just cosmetic purposes. ... prescribed body-fat standard, measured by the circumference-based tape method. The tape-test is used ...
(Date:5/27/2016)... ... May 27, 2016 , ... With a team ... and food industries. Aside from its GMP accreditation, Validation Center is also a ... certified products, services and staff. , Validation Center is ISO17025 accredited and only ...
(Date:5/26/2016)... ... May 26, 2016 , ... Cabot Corporation, ... defective respirators, according to court documents and SEC filings. A jury has ... Tyler v. American Optical Corporation, Case No. BC588866, Los Angeles County, California. The ...
Breaking Medicine News(10 mins):
(Date:5/25/2016)... 2016 According to market research ... and Demand Forecast to 2022 - Industry Insights by ... published by P&S Market Research, the global insulin delivery ... and it is expected to grow at a CAGR ... pump segment is expected to witness the fastest growth ...
(Date:5/25/2016)... May 25, 2016  Granger Diagnostics today announced immediate ... wounds and infections. This test ensures discovery of ... viruses. The test requires only a simple swab of ... David G. Bostwick , MD, Chief Medical ... wound healing: "We are excited to make available, ...
(Date:5/25/2016)... May 25, 2016 MedDay, a biotechnology ... that an oral presentation entitled "High doses of biotin in ... will be given by Professor Ayman Tourbah , Principal ... of the European Academy of Neurology (EAN) in ... disorders 3" will take place on Sunday, 29 May 2016 ...
Breaking Medicine Technology: