Navigation Links
MicroRNAs could increase the risk of amputation in diabetics
Date:1/12/2011

New research has found one of the smallest entities in the human genome, micro-RNA, could increase the risk of limb amputation in diabetic patients who have poor blood flow.

The study by Dr Andrea Caporali and colleagues in Professor Costanza Emanueli's research group in the Regenerative Medicine Section of the School of Clinical Sciences at the University of Bristol was funded by the Medical Research Council and is published online in Circulation: Journal of the American Heart Association.

The research group have shown in an experimental cell study that conditions mimicking diabetes and a lack of blood supply to a tissue increased a particular miRNA (miRNA-503) and impaired the ability of endothelial cells, which line the interior surface of blood vessels. Micro-RNAs (miRNAs) are small sections of ribonucleic acid (RNA) that can inhibit many genes.

Alternatively, slowing down miRNA-503 improved the capability of endothelial cells to duplicate and form into networks of small blood vessels. The researchers showed that microRNA-503 reduces cell growth and prevents the formation of blood vessels by direct binding and inhibition of cyclin E1 and Cdc25 mRNA.

Costanza Emanueli, Professorial Research Fellow in Vascular Pathology & Regeneration, said: "Because each miRNA can regulate many genes, they represent an exciting new target to correct diseases that have complex underlying mechanisms, like diabetes, rather than trying to target one specific gene. Our study is the first to provide evidence for a role of miRNAs in diabetes-induced defects in reparative angiogenesis."

The team subsequently investigated miR-503 and target gene expression in muscular specimens from the amputated ischaemic legs of diabetic patients. As controls, calf biopsies of non-diabetic and non-ischemic patients undergoing saphenous vein stripping were used. In diabetic muscles, miR-503 expression was remarkably higher, and plasma miR-50
'/>"/>

Contact: Joanne Fryer
joanne.fryer@bristol.ac.uk
44-117-331-7276
University of Bristol
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Caltech biologists discover microRNAs that control function of blood stem cells
2. Baby-led weaning is feasible but could cause nutritional problems for minority of infants
3. Optimism Could Help Kids Keep Depression at Bay
4. Pandemic flu strain could point way to universal vaccine
5. Link between signaling molecules could point way to therapies for epilepsy, stroke, other diseases
6. Infant Organ Donors Could Help Meet Transplant Needs: Study
7. Thermostatic mixer valves could significantly reduce the risk of scalding in children, study finds
8. Biological joints could replace artificial joints soon
9. Scientists Aim for Test That Could Spot Single Cancer Cell in Blood
10. Maybe Scrooge Couldnt Help Being Hard-Hearted
11. Could Santas Lack of Sleep on Christmas Eve Harm His Health?
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/25/2014)... the popular online supplier of wedding dresses and special occasion ... black one-shoulder cocktail dresses . In addition, all these elegant ... prices, up to 70% off. , The development ... You know, we have thousands of frequent callers in the ... can visit our website for more details. The current special ...
(Date:12/25/2014)... Recently, Dylan Queen, a famous online company supplying women’s ... discounted prom dresses, most of which are priced under ... company, the promotion is valid until Jan. 22, 2015; ... UK market. , The prom dresses in this new ... A-line strapless, empire strapless chiffon, one shoulder, floor-length, V-neck ...
(Date:12/25/2014)... 25, 2014 The short film “Color of ... in honor of a true 9/11 hero, Welles Remy Crowther. ... including the 24 hours of Nuremberg International Short Film Festival ... , Actress, screenwriter and director Luciana Lagana plays ... together with her husband, Gregory Graham - Graham ...
(Date:12/25/2014)... 2014 Recently, BellasDress has ... its wedding dresses. BellasDress has chosen their best-selling lace ... choices for the holiday season. , Now, BellasDress.com ... wedding gowns here at discount prices. The business hopes ... its website. , “All our elegant products ...
(Date:12/25/2014)... 2014 BambooFlooringChina.com sells many bamboo products ... flooring. Today, the company announces big discounts on ... and colors. , BambooFlooringChina.com is the world’s leader in ... is valid until Jan. 20, 2015. , The bamboo ... with a natural thread. All the bamboo strips for ...
Breaking Medicine News(10 mins):Health News:iFitDress.com: Black One-Shoulder Cocktail Dresses for 2015 2Health News:Dylan Queen: Cheap Prom Dresses for the UK Market 2Health News:The True 9/11 Hero Story “Color of Honor” Premieres in Germany and Bangladesh: Luciana Lagana Plays the Mother of the Lead and Co-Produces with Blaise Dolcemaschio. 2Health News:The True 9/11 Hero Story “Color of Honor” Premieres in Germany and Bangladesh: Luciana Lagana Plays the Mother of the Lead and Co-Produces with Blaise Dolcemaschio. 3Health News:BellasDress.com’s Christmas Sale: Trendy Wedding Dresses With Big Discounts 2Health News:Various Styles of Bamboo Mats in Many Colors from BambooFlooringChina.com 2
... Eating red meat or processed meat can increase your ... in the Journal of the National Cancer Institute. ... is why often colon cancer is also called colorectal ... growth of abnormal or malignant cells within the lining ...
... impotence latest research shows that Viagra //(sildenafil) may also ... and breathe easier. Children diagnosed with pulmonary arterial hypertension ... extremely high in the arteries that supply the lungs, ... and if left untreated, could eventually lead to death ...
... the study published in the Archives of Internal Medicine high ... of premenstrual syndrome (PMS). Previous studies have shown that blood ... PMS.PMS that occurs monthly during the reproductive age of ... a number of symptoms in a significant number of women ...
... family bonds, its friendship that can keep people have a ... that the benefits of having friends do affect the health ... life expectancy can get significantly increased. ,The researchers ... person or over the phone for about ten years in ...
... second phase of study that is trying new approaches ... of the drug topotecancan be more effective in children ... Children's Research Hospital, US, feel that the cancer drug ... patient of neuroblastoma as not all doses are effective ...
... to 6 years of age will eat as much as they ... behavior suggests that preschool children eat as much as they are ... was accepted that these children ate depending on how much they ... last meals were. New research had just negated all these factors ...
Cached Medicine News:
(Date:12/24/2014)... , Dec. 24, 2014 /CNW/ - ... is being recalled after Health Canada tests confirmed it ... health risks (beta-methylphenethylamine and phenylpropylmethylamine). The distributor, Empire Health ... recalling the product from retail stores across ... building purposes, including for weight loss and increased energy. ...
(Date:12/24/2014)...  Novastem, a leader in regenerative medicine, announces ... study for ischemic stroke at Clinica Santa Clarita. ... account for 87 percent of all stroke cases. ... study, entitled "Internal Research Protocol in Combination Therapy ... and Intrathecal Administration of Neural Stem Cells in ...
(Date:12/24/2014)... , Dec. 24, 2014  Actavis plc ... the Company has received a complete response letter ... for its New Drug Application (NDA) for the ... the treatment of hypertension.   Photo - ... are disappointed in the receipt of a complete ...
Breaking Medicine Technology:"Jetfuel Superburn" recalled after Health Canada tests find undeclared drug ingredients 2Novastem Treats First Patient Using Stemedica's Mesenchymal and Neural Stem Cell Combination Therapy for Ischemic Stroke 2Novastem Treats First Patient Using Stemedica's Mesenchymal and Neural Stem Cell Combination Therapy for Ischemic Stroke 3Novastem Treats First Patient Using Stemedica's Mesenchymal and Neural Stem Cell Combination Therapy for Ischemic Stroke 4Actavis Confirms Complete Response Letter for Nebivolol/Valsartan Fixed-Dose Combination for Hypertension 2Actavis Confirms Complete Response Letter for Nebivolol/Valsartan Fixed-Dose Combination for Hypertension 3Actavis Confirms Complete Response Letter for Nebivolol/Valsartan Fixed-Dose Combination for Hypertension 4
... Oct. 27 According to Millennium Research Group ... intelligence, the European arthroscope market generated over $30 ... over 2009 due to decreasing scope prices and ... Due to unfavorable economic conditions, manufacturers are ...
... today announced that it has received approval from the ... (US 7,815,929) regarding a method for the preparation, storage ... very nature, the process of compounding suppositories is cumbersome, ... Indu Muni, founder, chairman, and CEO of CutisPharma, Inc. ...
Cached Medicine Technology:Despite Rising Procedure Volumes, the $30 Million European Arthroscope Market Experienced Nominal Growth in 2010 2Despite Rising Procedure Volumes, the $30 Million European Arthroscope Market Experienced Nominal Growth in 2010 3CutisPharma Announces Issuance of an Additional Patent for Suppository Compounding 2
... D-Stat Flowable Hemostat has a ... topical application, such as vascular access ... It is also used as an ... of tissue tracts of femoral access ...
... Hemostasis Pad is intended for use in the ... sites and percutaneous catheters or tubes. The Pad ... powerful hemostatic agent. Chitosan gel is twice as ... which it is derived. When placed over the ...
... The EVS is engineered to close ... The ergonomic stapler with a simple ... operator. A deliver sheath gently ... maintains control of the site before, ...
The Prostar XL 8 is a suture mediated closure system. It can be used with 8F sheath. It has two 3-0 braided polyester sutures and also has the safety of guidewire....
Medicine Products: