Navigation Links
MicroRNAs can convert normal cells into cancer promoters
Date:11/21/2012

When fibroblast-dense tissues are infiltrated by cancer cells, however, "intimate cross-talk between fibroblasts and cancer cells" can covert them to cancer-associated fibroblasts, Lengyel said, "shifting them into a new role."

"Only a few years ago scientists learned how to reprogram normal cells into cells that can give rise to any cell type in the body," said the second lead author on the study Marcus Peter, PhD, professor of medicine at Northwestern University Feinberg School of Medicine. "Our work demonstrates that cancer cells also have the ability to reprogram cells in their environment into cells that support their growth and that this process involves microRNAs."

The researchers found that cancer cells caused normal fibroblasts to reduce production of two microRNAs, miR-31 and miR-214, and to increase production of miR-155. Since microRNAs usually block gene expression, reduced levels increased expression of several of their target genes. Many of those genes are involved in the production of the chemical signals associated with CAFs.

The most highly upregulated such signal, known as CCL5, is a "key tumor-promoting factor," the authors show. When human ovarian cancer cells and CAFs were co-injected into mice, the tumor cells soon replaced normal ovarian structures. Antibodies that neutralized CCL5 inhibited this augmented growth.

"One strength of our study is that we used tumor cells and CAFs from patients, rather than cell lines," said Lengyel, a gynecologic oncologist who specializes in the surgical treatment of women with ovarian cancer. "Our model system is as close as possible to the real situation."

"Therapeutic approaches targeting microRNAs in cancer cells are under development," added Peter. "Our work suggests that it might be possible to modify microRNA expression in cancer-associated fibroblasts for therapeutic benefit."


'/>"/>

Contact: John Easton
john.easton@uchospitals.edu
773-795-5225
University of Chicago Medical Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Pint-size microRNAs show promise against weighty problem, researchers say
2. Device converting images into music helps individuals without vision reach for objects in space
3. Documenting womens experiences with chromosome abnormalities found in new prenatal test
4. Abnormal carotid arteries found in children with kidney disease
5. Double drug combo could shut down abnormal blood vessel growth that feeds disease
6. Overweight Teens Typically Eat Less Than Normal-Weight Peers
7. Overweight Teens Typically Eat Less Than Normal-Weight Peers
8. Even High-Normal Blood Sugar Tied to Brain Shrinkage
9. Normal weight individuals with belly fat at highest CVD risk
10. People of normal weight with belly fat at highest death risk, Mayo Clinic study
11. Normal-Weight People With Type 2 Diabetes Have Higher Death Risk: Study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/23/2014)... HealthDay Reporter TUESDAY, Sept. ... low birth weights, breast milk is more likely than a ... as cytomegalovirus (CMV), a new study finds. The researchers ... all of whom weighed 3.3 pounds or less and many ... infection, to see whether breast milk or transfusions carried the ...
(Date:9/23/2014)... -- Both drinking and getting drunk at an early ... high school students, a new study suggests. The ... who drink, could help expand alcohol-prevention efforts aimed at ... them from becoming binge drinkers, the researchers suggested. , ... use and progression to first heavy use as risk ...
(Date:9/23/2014)... (PRWEB) September 23, 2014 What ... The National Quality Forum (NQF) released a ... http://www.qualityforum.org/WorkArea/linkit.aspx?LinkIdentifier=id&ItemID=77687 ), and an infographic ( http://bit.ly/1tX3lzA ) ... cost of healthcare, how patients define affordability, and ... to get the best possible healthcare at the ...
(Date:9/23/2014)... 2014 (HealthDay News) -- Few children who ... behavioral therapy, and the rates vary six-fold across ... finds. Medication alone can manage symptoms for ... if they also receive behavioral therapy (psychotherapy), the ... data in more than 1,500 counties across the ...
(Date:9/23/2014)... grow up to earn up to 18 percent less ... Lundborg of Lund University, Paul Nystedt of Jnkping University ... all in Sweden. The team compared extensive information from ... the results are published in Springer,s journal Demography ... 145,193 Swedish-born brothers who enlisted in the Swedish National ...
Breaking Medicine News(10 mins):Health News:Breast Milk a Risk for Spreading Common Virus to Preemies, Study Finds 2Health News:Breast Milk a Risk for Spreading Common Virus to Preemies, Study Finds 3Health News:Younger Age at First Drink, Higher Odds for Problem Drinking: Study 2Health News:Younger Age at First Drink, Higher Odds for Problem Drinking: Study 3Health News:Finding Affordable Care: Asking the Right Question is Key 2Health News:Kids Taking ADHD Drugs Get Little Psychotherapy: Study 2Health News:Note to young men: Fat doesn't pay 2
... awareness month, they would step up weekly workouts with ... facilities offered by the apartment community, CHICAGO, Feb. ... by eating right and working out on a weekly ... workout routine with convenient access to,workout facilities. During national ...
... country will become the "Gateway to,Healthy Living" for tens ... take better care of themselves., BOSTON, Feb. 28 ... program, participating health clubs will open their,doors -- free ... lives and,benefit from the supportive environment and professional knowledge ...
... Guidance for 2008, - Total Revenues Up 28% to $977.3mm for Full Year; Up 27% to ... Fourth Quarter, ... down 11% to $1.46); Up 27% to $0.47 for Fourth Quarter (GAAP EPS ... up 62% to $0.47), - Continuing New ...
... Puerto ... Rico, ... announced a multi-faceted marketing campaign designed to,promote ocular health and highlight the ... and Central,America., Following its launch of 1-DAY ACUVUE(R) MOIST(TM) in 2007,s ...
... Run Ads in Heavy Rotation Through Primary, ... of Ohio,s crucial,primary vote Tuesday, the National Nurses ... campaign across Ohio with,an emphatic message to the ... support real healthcare reform., The 60-second radio ...
... lupus, can affect nearly any part of the body, ... brain. Along with joint pain, muscle pain, unexplained ... events often accompany this autoimmune disease. Depending on ... patients experience signs and symptoms of neuropsychiatric (NP) disease. ...
Cached Medicine News:Health News:National Survey Reveals Most Renters Want What They Do Not Have: On-Site Workout Facilities 2Health News:Health Clubs Open Doors Free for 5th Annual Get Active America! Month and Become Gateway to Healthy Living 2Health News:Health Clubs Open Doors Free for 5th Annual Get Active America! Month and Become Gateway to Healthy Living 3Health News:inVentiv Health Reports Record Financial Results for Fourth Quarter and Full Year 2007 2Health News:inVentiv Health Reports Record Financial Results for Fourth Quarter and Full Year 2007 3Health News:inVentiv Health Reports Record Financial Results for Fourth Quarter and Full Year 2007 4Health News:inVentiv Health Reports Record Financial Results for Fourth Quarter and Full Year 2007 5Health News:inVentiv Health Reports Record Financial Results for Fourth Quarter and Full Year 2007 6Health News:inVentiv Health Reports Record Financial Results for Fourth Quarter and Full Year 2007 7Health News:inVentiv Health Reports Record Financial Results for Fourth Quarter and Full Year 2007 8Health News:inVentiv Health Reports Record Financial Results for Fourth Quarter and Full Year 2007 9Health News:inVentiv Health Reports Record Financial Results for Fourth Quarter and Full Year 2007 10Health News:inVentiv Health Reports Record Financial Results for Fourth Quarter and Full Year 2007 11Health News:inVentiv Health Reports Record Financial Results for Fourth Quarter and Full Year 2007 12Health News:inVentiv Health Reports Record Financial Results for Fourth Quarter and Full Year 2007 13Health News:inVentiv Health Reports Record Financial Results for Fourth Quarter and Full Year 2007 14Health News:inVentiv Health Reports Record Financial Results for Fourth Quarter and Full Year 2007 15Health News:Eyes on Puerto Rico: Johnson & Johnson Markets New Contact Lenses Directly to Consumers 2Health News:Eyes on Puerto Rico: Johnson & Johnson Markets New Contact Lenses Directly to Consumers 3Health News:Nurses Launch Major Ohio Radio Ad Campaign Telling Candidates: Stop Selling Insurance and Back Real Reform 2Health News:Nurses Launch Major Ohio Radio Ad Campaign Telling Candidates: Stop Selling Insurance and Back Real Reform 3Health News:Autoantibodies and neuropsychiatric events in lupus 2Health News:Autoantibodies and neuropsychiatric events in lupus 3
(Date:9/23/2014)... MINNETONKA, Minn. , Sept. 23, 2014   MedNet ... clinical study management systems, is pleased to announce that it ... for Clinical Data Management (SCDM) Annual Conference, to be held ... Las Vegas , Nevada. MedNet team members, in conjunction ... Partner Organizations who will also be in attendance, will ...
(Date:9/23/2014)... Fla. and DUBLIN ... (OTC-BB: TNIB) ("we" or the "Company"), a biotechnology ... therapies for autoimmune diseases in emerging nations, today ... approved our common stock for DTC,s Deposit and ... Automated Securities Transfer Service ("FAST") transfer agent as ...
(Date:9/23/2014)... CHICAGO , Sept. 23, 2014  Hill-Rom (NYSE: ... agreement with Providence Health ( Renton, WA ... new agreement expands the companies, existing relationship as Hill-Rom ... Maternal, and Bariatric capital bed frame and surface products. ... largest health systems in the U.S.  It operates 34 ...
Breaking Medicine Technology:MedNet Solutions - Proud To Sponsor The SCDM 2014 Annual Conference 2TNI BioTech, Inc. Announces Its Stock is Now DTC DWAC/FAST Eligible 2TNI BioTech, Inc. Announces Its Stock is Now DTC DWAC/FAST Eligible 3TNI BioTech, Inc. Announces Its Stock is Now DTC DWAC/FAST Eligible 4Hill-Rom Announces Seven-Year, Sole-Source Contract with Providence Health 2
... Stage Invention is Advancement toward Artificial Lungs, ... those suffering from lung ailments take note: Innovation ... from Battelle has earned a,patent for generating oxygen ... technology creates oxygen and controls carbon dioxide using ...
... Data ... Presentations -, SAN FRANCISCO, Sept. 24 ... development of,compounds for the treatment of cardiovascular disease, announced today that,it has ... study, including the sub-study of patients who received an,additional 3 months of ...
Cached Medicine Technology:Battelle Scientists Named on Patent for Making Oxygen From Light and Water 2VIA Pharmaceuticals Completes Patient Visits in Phase 2 Acute Coronary Syndrome (ACS) Trial 2VIA Pharmaceuticals Completes Patient Visits in Phase 2 Acute Coronary Syndrome (ACS) Trial 3VIA Pharmaceuticals Completes Patient Visits in Phase 2 Acute Coronary Syndrome (ACS) Trial 4
The Bledsoe Flatform Boot is designed with a flat innersole for procedures where toe dorsiflexion is not permissible....
The Bledsoe Achilles Boot saves time by eliminating casting series required to stretch the achilles tendon during rehab....
... Cronin, Inc. is a ... Footwear, Orthopedic Softgoods, and ... Our products are of ... available in the USA ...
... Bauerfeind™ AchilloTrain® The viscoelastic insert runs ... application of pressure and targeted intermittent ... reduction of painful irritation of the ... integrated viscoelastic heel wedge (raises heel ...
Medicine Products: