Navigation Links
MicroRNAs can convert normal cells into cancer promoters
Date:11/21/2012

When fibroblast-dense tissues are infiltrated by cancer cells, however, "intimate cross-talk between fibroblasts and cancer cells" can covert them to cancer-associated fibroblasts, Lengyel said, "shifting them into a new role."

"Only a few years ago scientists learned how to reprogram normal cells into cells that can give rise to any cell type in the body," said the second lead author on the study Marcus Peter, PhD, professor of medicine at Northwestern University Feinberg School of Medicine. "Our work demonstrates that cancer cells also have the ability to reprogram cells in their environment into cells that support their growth and that this process involves microRNAs."

The researchers found that cancer cells caused normal fibroblasts to reduce production of two microRNAs, miR-31 and miR-214, and to increase production of miR-155. Since microRNAs usually block gene expression, reduced levels increased expression of several of their target genes. Many of those genes are involved in the production of the chemical signals associated with CAFs.

The most highly upregulated such signal, known as CCL5, is a "key tumor-promoting factor," the authors show. When human ovarian cancer cells and CAFs were co-injected into mice, the tumor cells soon replaced normal ovarian structures. Antibodies that neutralized CCL5 inhibited this augmented growth.

"One strength of our study is that we used tumor cells and CAFs from patients, rather than cell lines," said Lengyel, a gynecologic oncologist who specializes in the surgical treatment of women with ovarian cancer. "Our model system is as close as possible to the real situation."

"Therapeutic approaches targeting microRNAs in cancer cells are under development," added Peter. "Our work suggests that it might be possible to modify microRNA expression in cancer-associated fibroblasts for therapeutic benefit."


'/>"/>

Contact: John Easton
john.easton@uchospitals.edu
773-795-5225
University of Chicago Medical Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Pint-size microRNAs show promise against weighty problem, researchers say
2. Device converting images into music helps individuals without vision reach for objects in space
3. Documenting womens experiences with chromosome abnormalities found in new prenatal test
4. Abnormal carotid arteries found in children with kidney disease
5. Double drug combo could shut down abnormal blood vessel growth that feeds disease
6. Overweight Teens Typically Eat Less Than Normal-Weight Peers
7. Overweight Teens Typically Eat Less Than Normal-Weight Peers
8. Even High-Normal Blood Sugar Tied to Brain Shrinkage
9. Normal weight individuals with belly fat at highest CVD risk
10. People of normal weight with belly fat at highest death risk, Mayo Clinic study
11. Normal-Weight People With Type 2 Diabetes Have Higher Death Risk: Study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/3/2015)... ... July 03, 2015 , ... ... healthcare providers, has been retained to lead a national chief nursing officer ... top-ranked executive search firms in the healthcare industry, B. E. Smith has recently ...
(Date:7/3/2015)... ... 2015 , ... First Choice Emergency Room , the largest network of ... the new Medical Director of its Frisco facility. , “We are pleased to announce ... Dr. James M. Muzzarelli, Executive Medical Director of First Choice Emergency Room. , ...
(Date:7/2/2015)... ... July 02, 2015 , ... sweetFrog Enterprises, LLC. is pleased to ... the first sweetFrog store located in Mississippi. The premium frozen yogurt chain was listed ... The store, located at 104 Railroad Avenue, New Albany, MS 38652, will have a ...
(Date:7/2/2015)... ... July 02, 2015 , ... When Walker ... at the University of Minnesota, they knew it would save the university energy ... an award-winning choice: the total energy savings after installation was an impressive 89 ...
(Date:7/2/2015)... ... July 02, 2015 , ... As Americans celebrate the Fourth of July ... cancer is on the rise. July is UV Safety Month, and physicians at American ... importance of getting skin checks. Experts say most skin cancers can be found early ...
Breaking Medicine News(10 mins):Health News:Jane Phillips Medical Center Retains B. E. Smith to Recruit New Chief Nursing Officer 2Health News:Jane Phillips Medical Center Retains B. E. Smith to Recruit New Chief Nursing Officer 3Health News:First Choice Emergency Room Announces Dr. Mariah N. Manzanares as Medical Director of Frisco, TX Facility 2Health News:First Choice Emergency Room Announces Dr. Mariah N. Manzanares as Medical Director of Frisco, TX Facility 3Health News:sweetfrog Opens First Location in Mississippi 2Health News:Kenall’s TekDek™ Helps University Achieve Award-Winning Energy Savings in Parking Structure Lighting Retrofit 2Health News:Local Physicians Warn of Holiday Health Hazards 2Health News:Local Physicians Warn of Holiday Health Hazards 3Health News:Local Physicians Warn of Holiday Health Hazards 4
... WINSTON-SALEM, N.C. Sept. 16, 2011 A study ... colleagues suggests that a high intake of calcium causes ... absorbers of the mineral. "High dietary intake of ... the explanation for this observation has been elusive," said ...
... THURSDAY, Sept. 15 (HealthDay News) -- The rate of new lung ... as it has for men in for years, a new U.S. ... 2.2 percent per year on average for women between 2006 and ... 2006, according to the U.S. Centers for Disease Control and Prevention. ...
... speaking on Capitol Hill today demonstrated that the Great ... older workers, although programs such as the federal Senior ... some valuable benefits to this disadvantaged demographic group. ... of National Employ Older Workers Week was titled, ...
... of young children admitted to hospitals or seen in ... dose of medication has risen dramatically in recent years, ... study. The rise in exposure to ... for Disease Control and Prevention has established the PROTECT ...
... Alzheimer,s diagnosis presents new challenges to the public, physicians and ... you want to know? How should doctors tell you your ... diagnosed Americans still in the workplace? Despite the ... effective interventions have been identified to stop the progression of ...
... , THURSDAY, Sept. 15 (HealthDay News) -- Men and women ... their eyelids appear to face a higher risk of heart ... new Danish research suggests. The link between the skin ... rather than a clear case of "cause and effect." ...
Cached Medicine News:Health News:Genetics may explain why calcium increases risk for prostate cancer 2Health News:Lung Cancer Rates Begin to Decline for U.S. Women 2Health News:Congressional briefing sheds light on poor seniors' employment struggles 2Health News:Congressional briefing sheds light on poor seniors' employment struggles 3Health News:Number of children poisoned by medication rising dramatically, study says 2Health News:Safeguards needed to prevent discrimination of early Alzheimer's patients in the workplace 2Health News:Cholesterol Deposits Around Eyes Linked to Heart Risk 2
(Date:7/2/2015)... BGI a annoncé aujourd,hui que son ... situé à Hong Kong ... Pathologists  (Collège des pathologistes américains, ou CAP). Les ... constituent le premier laboratoire clinique de ... du CAP en Chine, car il satisfait les ...
(Date:7/2/2015)... FORT LAUDERDALE, Fla. , July 2, 2015 ... & Co., is pleased to announce that its ... Inc. ("Insight Beverages") to Kerry Group plc (ISE: ... focused on taste and nutrition systems, as well ... food, beverage and pharmaceutical markets. Farlie Turner served ...
(Date:7/2/2015)... 26, 2015 Research and Markets( ... D Market by Analog, Application, End-User & by Region - ... offering. This market is projected to reach about ... in different applications and rising opportunities in countries such as ... Italy , and Brazil ...
Breaking Medicine Technology:BGI obtient la certification du Collège des pathologistes américains (CAP) 2Farlie Turner's Consumer Group Completes Sale of Insight Beverages to Kerry 2Vitamin D Market by Analog, Application, End-User & by Region - Global Trends & Forecast to 2020: Increasing Recommendation By Doctors & Associations 2Vitamin D Market by Analog, Application, End-User & by Region - Global Trends & Forecast to 2020: Increasing Recommendation By Doctors & Associations 3
... Complete procedure information to facilitate diagnostic ... monitor is a sterile, disposable device used ... nucleus during discography procedures. The device will ... display it in a digital format. The ...
Smith & Nephew's CDS System is developed exclusively for discography., Developed exclusively for discography, it is the first system designed to measure true disc pressure and record real-time proce...
The ACCU-DISC™ pressure monitoring system offers the advantage of accurate delivery of fluids to the body with the ability to monitor the pressure of those fluids in discography interpretation....
The °CureWrap is one-piece garment offers maximum available surface coverage, while avoiding the sterilized fields of operation....
Medicine Products: