Navigation Links
MicroRNAs can convert normal cells into cancer promoters
Date:11/21/2012

Unraveling the mechanism that ovarian cancer cells use to change normal cells around them into cells that promote tumor growth has identified several new targets for treatment of this deadly disease.

In the December issue of the American Association for Cancer Research journal Cancer Discovery, a team or researchers from the University of Chicago Medicine and Northwestern University Feinberg School of Medicine show that ovarian cancer cells induce nearby cells to alter their production of three microRNAssmall strands of genetic material that are important regulators of gene expression.

By changing gene expression, microRNAs can modify a cell's function. In this case, they convert normal, healthy fibroblasts into cancer-associated fibroblasts (CAFs). These CAFs pump out chemical signals telling cancer cells to multiply, invade healthy tissues and travel to distant sites in the abdomen. Importantly, by reversing the microRNA signals the researchers were able to cause CAFs to revert to normal fibroblasts.

"These cancer-supporting cells provide a novel and appealing treatment target," said one of the lead authors of the study Ernst Lengyel, MD, PhD, professor in the department of obstetrics and gynecology at the University of Chicago. "Cancer cells mutate rapidly, which enables them to develop drug resistance. But cancer-associated fibroblasts are genetically stable," he said. "Their harmful behavior is driven by the microRNAs. Inhibiting those signals is a new way to fight this disease. It disrupts the cancer's support system and is unlikely to evolve resistance."

"With ovarian cancer," Lengyel added, "we desperately need new treatments. "There have been no new approaches introduced into the clinic for years, and thus no major improvements in patient survival."

Fibroblasts are the primary cellular component of connective tissue. They provide the structural framework for other tissues and aid in wound healing.
'/>"/>

Contact: John Easton
john.easton@uchospitals.edu
773-795-5225
University of Chicago Medical Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Pint-size microRNAs show promise against weighty problem, researchers say
2. Device converting images into music helps individuals without vision reach for objects in space
3. Documenting womens experiences with chromosome abnormalities found in new prenatal test
4. Abnormal carotid arteries found in children with kidney disease
5. Double drug combo could shut down abnormal blood vessel growth that feeds disease
6. Overweight Teens Typically Eat Less Than Normal-Weight Peers
7. Overweight Teens Typically Eat Less Than Normal-Weight Peers
8. Even High-Normal Blood Sugar Tied to Brain Shrinkage
9. Normal weight individuals with belly fat at highest CVD risk
10. People of normal weight with belly fat at highest death risk, Mayo Clinic study
11. Normal-Weight People With Type 2 Diabetes Have Higher Death Risk: Study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/22/2014)... 22, 2014 The Philadelphia 100, which ... Philadelphia region each year, is considered a hallmark of ... MK Precision is proud to announce it has earned ... Precision will attend the Philadelphia 100 awards ... premiere business events of the year, as well as ...
(Date:9/22/2014)... 22, 2014 Locating the top rates ... now easier using the Quotes Pros portal online. There ... local universal life insurance pricing from different companies at ... that are easily viewed when using the finder system ... of coverage. The plan data can be reviewed after ...
(Date:9/22/2014)... 22, 2014 (HealthDay News) -- All sexually active ... most common sexually transmitted infections: chlamydia and gonorrhea, ... Services Task Force. The task force ... than 24 years of age and pregnant women. ... develop noticeable symptoms. As a result, many infections ...
(Date:9/22/2014)... New York (PRWEB) September 22, 2014 ... against Boston Scientific Corp. continue to move forward ... U.S. District Court, Southern District of West Virginia, ... a new Docket Control Order was issued by ... number of matters pertaining to the upcoming trial ...
(Date:9/22/2014)... HealthDay Reporter MONDAY, Sept. 22, 2014 (HealthDay ... care units (NICU) set up private rooms for parents to ... Researchers at one children,s hospital found that preemies gained weight ... NICU switched from the traditional "open-bay" layout to private rooms ... the journal Pediatrics , add to evidence that private ...
Breaking Medicine News(10 mins):Health News:MK Precision Announces Spot on Philadelphia 100 Fastest Growing Companies 2Health News:Universal Life Insurance Prices for Adults Added to National Insurer Portal Online 2Health News:Screen Women for Chlamydia, Gonorrhea, Experts Say 2Health News:Transvaginal Mesh Lawsuits Move Forward, With Issuance of New Order in Federal Boston Scientific Litigation, Bernstein Liebhard LLP Reports 2Health News:Transvaginal Mesh Lawsuits Move Forward, With Issuance of New Order in Federal Boston Scientific Litigation, Bernstein Liebhard LLP Reports 3Health News:Transvaginal Mesh Lawsuits Move Forward, With Issuance of New Order in Federal Boston Scientific Litigation, Bernstein Liebhard LLP Reports 4Health News:Newborn ICUs With Private Family Rooms Benefit Preemies: Study 2Health News:Newborn ICUs With Private Family Rooms Benefit Preemies: Study 3
... , National PSA to run in all playoff games this ... 16 The National Football League (NFL) and the NFL Players ... to aid victims of the earthquake in Haiti . The NFL ... weekend,s playoff games valued at $1.5 million to promote donations. ...
... ... Bubble Spa is now available for purchase online and from many UK hot tub stores. ... tubs that are made in China by a leading inflatable products manufacturer, Oriental Recreational Products ... (PRWEB) January 16, ...
... ... receivable management services, has moved its National Account Service Center and Corporate Headquarters to ... ... one of the nation’s leading providers of accounts receivable management services, has moved its ...
... , , , OAKLAND, Calif. , ... up to volunteer for Haiti disaster relief,  believed to be ... United which is coordinating the effort, and working around the clock to ... Haiti . Nurses from other countries are signing up through the NNU ...
... , SAN FRANCISCO , Jan. 15 A Good ... ideas in San Francisco , plans to give $100,000 to ... of the Chase Community Giving contest sponsored by JPMorgan Chase & Co. , ... homelessness within the Bay Area, we feel that it is of the utmost ...
... To ... million as part of the coordinated United Nations Flash Appeal. , ... United Nations, NY (Vocus) January 15, 2010 -- Estimates ... affected by Haiti’s earthquake have led to an urgent appeal to meet their emergency maternal ...
Cached Medicine News:Health News:NFL Donates More Than $2 Million for Red Cross Disaster Response in Haiti 2Health News:NFL Donates More Than $2 Million for Red Cross Disaster Response in Haiti 3Health News:NFL Donates More Than $2 Million for Red Cross Disaster Response in Haiti 4Health News:Web's Newest, Sub-1000 Range of Hot Tubs Now Available For Purchase Online! 2Health News:Web's Newest, Sub-1000 Range of Hot Tubs Now Available For Purchase Online! 3Health News:TekCollect Opens New National Account Service Center and Corporate Headquarters 2Health News:Nearly 7,500 RNs Ready to Deploy to Haiti 2Health News:San Francisco Charity A GOOD IDEA to Give $100,000 to Haiti Victims Upon Winning Nationwide Charity Program 2Health News:Appeal Launched for Emergency Assistance to Thousands of Pregnant Women at High Risk in Haiti 2
(Date:9/22/2014)... , Sept. 22, 2014 ... the U.S. commercial launch of its foot plating system ... Paragon 28.  The GORILLA TM R3CON PLATING SYSTEM ... the Monster TM & Mini-Monster TM Screw ... Comprised of 10 interchangeable subsystems, the GORILLA TM ...
(Date:9/22/2014)... Research and Markets ( ... the  "Global Remotes Market 2014-2018"  report to ... Remotes/remote controls are devices that ... such as smart TVs, set top boxes, ... distance. Remote controls are small wireless handheld ...
(Date:9/22/2014)... -- Final shortlist announced, winners to ... The second edition of the much-awaited VCCircle Healthcare Awards is round ... final nominations for the 2014 honours.  The names of ... 25 at The Taj Mahal Palace, Mumbai . The ... variety of qualitative and quantitative parameters - such as ...
Breaking Medicine Technology:Paragon 28, Inc. Launches the GORILLA(TM) R3CON PLATING SYSTEM 2Global Remotes Market 2014-2018 2Global Remotes Market 2014-2018 3Recognising Impactful Healthcare Companies at VCCircle Healthcare Awards 2014 2Recognising Impactful Healthcare Companies at VCCircle Healthcare Awards 2014 3
... LYON, France, May 11, 2012 Mylan Inc. (Nasdaq: ... launched Atorvastatin Calcium Tablets, 10 mg, 20 mg, 40 ... the Netherlands and Ireland. Mylan has received marketing authorization ... its product immediately. Atorvastatin Calcium is the generic version ...
... /PRNewswire-iReach/ -- Electrochemical Oxygen Concepts (EO2™ ... chronic wound treatment device, announced it has been ... Federal Supply Schedule (FSS) contract, administered by The ... ® , a noninvasive, electrochemical low-dose tissue oxygenation ...
Cached Medicine Technology:Mylan Launches Generic LipitorĀ® in Five European Countries 2New Chronic Wound Treatment Device Receives Award from Veterans Healthcare Program 2New Chronic Wound Treatment Device Receives Award from Veterans Healthcare Program 3
... series facilitates fast and effective resection of ... shaped meniscal rim. The flat, crescent-shaped tip ... even the tightest joint spaces. Made in ... years of engineering experience in arthroscopy hand ...
... fast and effective resection of meniscal tears ... rim. The flat, crescent-shaped tip has an ... tightest joint spaces. Made in the U.S. ... engineering experience in arthroscopy hand instrument design ...
... provides fingertip ratchet disengagement allowing smooth, ratchet-free ... offers state-of-the-art quality in an instrument of ... durability. Low profile cutting tips allow access ... I instruments are available in just about ...
... design provides fingertip ratchet disengagement allowing smooth, ... program offers state-of-the-art quality in an instrument ... and durability. Low profile cutting tips allow ... Series I instruments are available in just ...
Medicine Products: