Navigation Links
MicroRNAs, EMT and cancer progression
Date:3/31/2008

In the April 1 issue of G&D, a research team led by Dr. Marcus Peter (University of Chicago) identifies the microRNA miR-200 as both a powerful indicator and regulator of the epithelial phenotype of cancer cells.

EMT (the epithelial-to-mesenchymal transition) is the conversion of an epithelial cell into a mesenchymal cell. Morphologically, EMT is characterized by a loss of cell adhesion and increased cell motility. At a molecular level, it is characterized by a decreased expression of the cell adhesion molecule and epithelial marker, E-cadherin, and an increased expression of the intermediate filament protein and mesenchymal cell marker, Vimentin.

EMT is a normal embryological process, but it is implicated in various adult pathologies including cancer metastasis.

Dr. Peter and colleagues analyzed 60 different cell lines from the National Cancer Institute, representing 9 different types of human cancers, and found that miR-200 is a consistent marker of cells that express E-cadherin but lack Vimentin. This was confirmed for primary ovarian cancer.

The researchers went on to show that miR-200 targets the transcriptional repressors of E-cadherin, ZEB1 and ZEB2, and that altering miR-200 levels in established cancer cell lines induced changes consistent with either inducing EMT or the reverse process, MET. Thus, in the context of cancer progression, decreased miR-200 expression increases ZEB1/2 activity, represses E-cadherin levels, and ultimately induces EMT.

"We expected an important process of cellular differentiation such as EMT to be regulated by microRNAs but were surprised by the extraordinarily tight control of EMT by miR-200 through the ZEB proteins. Our ability to reverse EMT by reintroducing miR-200 into cancer cells gives rise to the hope that this miRNA family might be useful in reversing cancer progression" explains Dr. Peter.


'/>"/>

Contact: Heather Cosel-Pieper
coselpie@cshl.edu
Cold Spring Harbor Laboratory
Source:Eurekalert

Page: 1

Related medicine news :

1. A new way to fight cancer: the silver shield
2. Many Women Unclear About Breast Cancer Treatments
3. You May Be the Key to Cancer Prevention
4. Study finds improvement in the care of children with cancer at the end of life
5. State of Cancer Care for Nations Poor and Minorities Is Focus of Conference in Washington
6. Hit One Out of the Park for the PA Breast Cancer Coalition
7. Saving cancer patients skin
8. Mens Health Policy Center Hosts Petition to Protest Government Barrier to Prostate Cancer Medications
9. Too many women still dying from breast cancer, says charity
10. A Picture Perfect Partnership: Olympus Raises Colorectal Cancer Awareness Through eBay Giving Works Auction
11. NSAIDs: Painkillers, inflammation inhibitors, anti-cancer drugs and new de-methylating agents
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/27/2014)... 2014 “Wekho” was featured on NewsWatch as ... coolest mobile applications on the iOS, Android, and Windows markets. ... conducted the app review and shared with viewers ... , An interesting new way to travel and experience the ... It’s called Wekho and it’s a free geolocation app ...
(Date:11/27/2014)... November 27, 2014 Dr. Ronald Receveur, who ... has a few oral health tips before patients dig into ... Louisville and New Albany affordable cosmetic dentistry, and ... in starch and sugar. While the staff wishes everyone a ... tips for how patients can enjoy a feast that is ...
(Date:11/27/2014)... Aria Health President and CEO Kathleen ... donated 200 Thanksgiving dinners on Friday, November 21, ... non-profit, community-based organization committed to serving vulnerable children, ... were assembled in the dining hall of the ... vulnerable low income seniors in the Philadelphia community. ...
(Date:11/27/2014)... Marietta, GA (PRWEB) November 27, 2014 "The ... the whole month of December is full of laughter as ... Tandy Wilson won by making a sweater from scratch. " ... lit Christmas tree, and if that weren't ridiculous enough, the ... on top. , For those interested in participating this ...
(Date:11/27/2014)... Santa Rosa, California (PRWEB) November 27, 2014 ... – Bringing You An Up-Close Look At This Year’s ... Prize Of An All-Inclusive Stay For Two At Their ... York-based High Times events or L.A.-based Hempcon, The Emerald ... state’s definitive county fair draws much of California’s original ...
Breaking Medicine News(10 mins):Health News:A New Geolocation Mobile Application and was Featured on NewsWatch Television on October 30, 2014 2Health News:New Albany Dental Practice Offers Oral Health Tips For Thanksgiving 2Health News:New Albany Dental Practice Offers Oral Health Tips For Thanksgiving 3Health News:New Albany Dental Practice Offers Oral Health Tips For Thanksgiving 4Health News:Aria Health Prepares and Donates 200 Thanksgiving Dinners 2Health News:Verde Pointe Dental Associates Hosts 2014 Ugly Holiday Sweater Contest 2Health News:Verde Pointe Dental Associates Hosts 2014 Ugly Holiday Sweater Contest 3Health News:The Emerald Cup 2014 Competition Partners | CannCast – Bringing You An Up-Close Look At This Year’s Entries and SKUNK Magazine Proudly Sponsoring This Year's Grand Prize 2Health News:The Emerald Cup 2014 Competition Partners | CannCast – Bringing You An Up-Close Look At This Year’s Entries and SKUNK Magazine Proudly Sponsoring This Year's Grand Prize 3Health News:The Emerald Cup 2014 Competition Partners | CannCast – Bringing You An Up-Close Look At This Year’s Entries and SKUNK Magazine Proudly Sponsoring This Year's Grand Prize 4
... difficult economic times, when people,s stress levels - both ... essential than ever, according to the experts at the ... many are today, we need all the help we ... and ADA Spokesperson Amy Jamieson-Petonic. "While eating healthfully is ...
... an affiliate member of ACA International – the Association of Credit ... , ... (Vocus) March 10, 2009 -- Prosodie Interactive, ... 33324-3223, was accepted as an affiliate member of ACA International – ...
... solutions for managing scientific R&D knowledge, information and processes, proudly ... Board of Directors. , ... Cork, ... LTD ("KineMatik"), providers of software solutions for managing scientific ...
... Amilpar ( BOVESPA: AMIL3, Bloomberg: AMIL3 BZ e Reuters: ... today its consolidated results for the periods ended on December ... at 3.2 million at the end of December, 18.4% up ... the previous quarter. , Adjusted Operating Revenues totaled ...
... 11 , New research released to ... (36%) of the nine million smokers in Great Britain are thinking,about ... of the economic,downturn. The poll also shows that one in ten ... on No Smoking Day. , No Smoking ...
... after treatment stops -SAN FRANCISCO, March 10 ... formulation of liquor carbonis distillate (LCD), known as ... cream in improving and controlling the symptoms of ... the American Academy of Dermatology,s 2009 Annual Meeting. ...
Cached Medicine News:Health News:A Registered Dietitian Can Help You Weather Economic Troubles Through Nutrition and Health, Says American Dietetic Association 2Health News:Business Becomes Affiliate Member of International Trade Association 2Health News:Mr. Ruben Jose King-Shaw Jr. to Join KineMatik Board of Directors 2Health News:Mr. Ruben Jose King-Shaw Jr. to Join KineMatik Board of Directors 3Health News:Amilpar - Revenues Increase by 26.5% and Adjusted Net Income Climbs 28.7% in 2008 2Health News:Recession leads 1 in 3 Smokers to cut Down or Quit 2Health News:Recession leads 1 in 3 Smokers to cut Down or Quit 3Health News:Study Shows Nonprescription LCD Topical Solution is More Effective than Prescription-Strength Calcipotriol Cream for Moderate Plaque Psoriasis 2Health News:Study Shows Nonprescription LCD Topical Solution is More Effective than Prescription-Strength Calcipotriol Cream for Moderate Plaque Psoriasis 3
(Date:11/26/2014)... -- According to the new research ... Battery, Pneumatic), by Product (Drill, Saw, Stapler, Reamer, ... (Orthopedic, ENT, Oral, Thoracic, Neurology) - Global Forecasts ... Instruments Market is estimated to be worth around ... expected to grow at a moderate CAGR during ...
(Date:11/26/2014)... , Nov. 25, 2014  Medtronic,s ... has been widely discussed in the media ... also creating a stronger leading player in one ... Kalorama Information.  The healthcare market research firm said ... will feature a diverse set of solutions spanning ...
(Date:11/26/2014)... , Nov. 25, 2014  Array BioPharma ... announced that its Chief Executive Officer, ... following upcoming conferences.  The public is welcome ... on the Array BioPharma website:  www.arraybiopharma.com ... 2014Time:1:30 p.m.  Eastern Time Location: Palace Hotel, ...
Breaking Medicine Technology:Powered Surgical Instruments Market Worth $2.1 Billion by 2019 2Powered Surgical Instruments Market Worth $2.1 Billion by 2019 3Powered Surgical Instruments Market Worth $2.1 Billion by 2019 4Medtronic - Covidien: Beyond Taxes, Deal Will Create Patient Monitoring Power, according to Kalorama Information 2Medtronic - Covidien: Beyond Taxes, Deal Will Create Patient Monitoring Power, according to Kalorama Information 3
... 2011 UCB, a leading biopharmaceutical company at the forefront ... College of Gastroenterology (ACG) meeting in Washington, D.C. by reinforcing ... disease. At this year,s ACG meeting, a large body of ... in treatment of moderate to severe Crohn,s disease. ...
... Natrix Separations, Inc. announced today new members of its leadership ... Officer and Molly S. McGlaughlin as Vice President of Business ... of Directors since mid-2010, and will continue to hold a ... C. Howie Honeyman, Ph.D. will continue as Senior Vice ...
Cached Medicine Technology:UCB Proudly Reinforces Long-Standing Commitment to Patients and Physicians at American College of Gastroenterology 2011 Annual Scientific Meeting 2UCB Proudly Reinforces Long-Standing Commitment to Patients and Physicians at American College of Gastroenterology 2011 Annual Scientific Meeting 3Natrix Separations Introduces New Leadership Team 2Natrix Separations Introduces New Leadership Team 3
Modular hip abduction system designed to provide superior fit, adjustability and functionality for optimum patient stability, comfort and compliance...
... Harness™ A Pavlik-type harness with greatly ... treatment of congenital hip dysplasia. Color-coded ... and antislip foot pieces.,Color-coded anterior straps ... can be made while the child ...
... in walker design in years. A real step forward! ... surfaces of the foot rest on adaptive areas of ... strike. The footbed in the sole conforms to the ... stability. , ,No leg length discrepancy; Heel height ...
... This low cost walker features a ... innersole. The low profile design minimizes leg ... with D-rings makes strapping quick and easy. ... to accomodate swollen ankles and extra bandaging. ...
Medicine Products: