Navigation Links
MicroRNAs, EMT and cancer progression
Date:3/31/2008

In the April 1 issue of G&D, a research team led by Dr. Marcus Peter (University of Chicago) identifies the microRNA miR-200 as both a powerful indicator and regulator of the epithelial phenotype of cancer cells.

EMT (the epithelial-to-mesenchymal transition) is the conversion of an epithelial cell into a mesenchymal cell. Morphologically, EMT is characterized by a loss of cell adhesion and increased cell motility. At a molecular level, it is characterized by a decreased expression of the cell adhesion molecule and epithelial marker, E-cadherin, and an increased expression of the intermediate filament protein and mesenchymal cell marker, Vimentin.

EMT is a normal embryological process, but it is implicated in various adult pathologies including cancer metastasis.

Dr. Peter and colleagues analyzed 60 different cell lines from the National Cancer Institute, representing 9 different types of human cancers, and found that miR-200 is a consistent marker of cells that express E-cadherin but lack Vimentin. This was confirmed for primary ovarian cancer.

The researchers went on to show that miR-200 targets the transcriptional repressors of E-cadherin, ZEB1 and ZEB2, and that altering miR-200 levels in established cancer cell lines induced changes consistent with either inducing EMT or the reverse process, MET. Thus, in the context of cancer progression, decreased miR-200 expression increases ZEB1/2 activity, represses E-cadherin levels, and ultimately induces EMT.

"We expected an important process of cellular differentiation such as EMT to be regulated by microRNAs but were surprised by the extraordinarily tight control of EMT by miR-200 through the ZEB proteins. Our ability to reverse EMT by reintroducing miR-200 into cancer cells gives rise to the hope that this miRNA family might be useful in reversing cancer progression" explains Dr. Peter.


'/>"/>

Contact: Heather Cosel-Pieper
coselpie@cshl.edu
Cold Spring Harbor Laboratory
Source:Eurekalert

0

GOOD

Page: 1

Related medicine news :

1. A new way to fight cancer: the silver shield
2. Many Women Unclear About Breast Cancer Treatments
3. You May Be the Key to Cancer Prevention
4. Study finds improvement in the care of children with cancer at the end of life
5. State of Cancer Care for Nations Poor and Minorities Is Focus of Conference in Washington
6. Hit One Out of the Park for the PA Breast Cancer Coalition
7. Saving cancer patients skin
8. Mens Health Policy Center Hosts Petition to Protest Government Barrier to Prostate Cancer Medications
9. Too many women still dying from breast cancer, says charity
10. A Picture Perfect Partnership: Olympus Raises Colorectal Cancer Awareness Through eBay Giving Works Auction
11. NSAIDs: Painkillers, inflammation inhibitors, anti-cancer drugs and new de-methylating agents
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/18/2013)... DF (PRWEB) May 18, 2013 The ... leading ayurvedic education institution in the West. Program is ... education. , Ayurveda is a healing modality practiced for ... ), it is considered that health begins when an ... profound understanding of their individual needs. Ayurveda aims to ...
(Date:5/18/2013)... CA (PRWEB) May 18, 2013 Rio ... has recently completed a stylish renovation that features tranquil, ... specialties. , From the ground up, this Morro ... with fresh flooring, soothing colors and comfortable spa beds. ... installed, including an Apilus epilator machine. The shampoo ...
(Date:5/18/2013)... Losing weight remains to be the biggest challenge for ... weight loss products available in the market today, Garcinia Cambogia ... newest weight loss supplement prove that dieting and exercising aren’t ... is a sub-tropical fruit that is shaped like a pumpkin ... a person’s appetite, while it effectively burns fat at the ...
(Date:5/18/2013)... (PRWEB) May 18, 2013 Spectrum ... Conference, on May 17-22 in Austin, TX where ... for educational and networking opportunities. , Spectrum ... flexible scope repair capabilities and certified ... valuable educational information on proper instrument care of ...
(Date:5/18/2013)... The topics that will be covered in the 1-day ... meetings, scrum artifacts, and scrum simulation (optional). One can earn ... These trainings are suitable for business analysts, project managers, developers, ... will be a part of the Scrum team, people outside ... and Scrum, but are unsure of what it is. ...
Breaking Medicine News(10 mins):Health News:Ayurveda Training in Mexico Offered by Escuela de Ayurveda de California, a Leading Institution in the West 2Health News:Rio Salon and Spa, a Beauty Salon in Morro Bay, Undergoes Makeover 2Health News:Lose Weight Without Dieting or Exercising with Garcinia Cambogia Select Now Available At HealthCareSupplementz.com 2Health News:Spectrum Surgical Attends Society of Gastroenterology Nurses and Associates' (SGNA) 40th Annual Conference in Austin, TX 2Health News:Affordable Scrum Trainings In Irvine by Conscires Agile Practices 2Health News:Affordable Scrum Trainings In Irvine by Conscires Agile Practices 3
... Seeking Feedback on Revisions to Standards , , WASHINGTON, ... comprehensive review of its standards, URAC , ... for public comment on revisions to its Health ... Security standards . URAC welcomes purchasers, policy ...
... June 18 /PRNewswire-Asia-FirstCall/ -- Jiangbo,Pharmaceuticals Enterprises, Inc. (OTC ... company with its principal operations in the,People,s Republic ... the China New,Drugs Trade Fair from June 26 ... Exhibition Center, and also plans to launch a ...
... , DENVER, June 18 DaVita Inc. (NYSE: ... those diagnosed with chronic kidney disease (CKD), today announced the ... Work for in Colorado Program. DaVita(R) is the only ... , (Logo: http://www.newscom.com/cgi-bin/prnh/20020729/DAVITALOGO ) , , "We ...
... ... Southeast Asia,s largest private hospital and one of the world,s top medical travel destinations, ... Quality Class (TQC) award for 2008. , ... Bangkok, Thailand (PRWEB) June 18, 2009 -- Bumrungrad International ...
... ... has been validated by ACHC as an organization dedicated to quality patient services, and ... ... -- Homefront Diabetic Services proudly announces its award of accreditation status by the Accreditation ...
... approach to choosing the best treatment options for early breast ... in a report from the 11th St Gallen conference. ... Annals of Oncology [1] today (Thursday 18 June), and ... from the conference of more than 4,800 participants from 101 ...
Cached Medicine News:Health News:Public Comment Period Open for HIPAA Privacy and Security Standards 2Health News:Public Comment Period Open for HIPAA Privacy and Security Standards 3Health News:Public Comment Period Open for HIPAA Privacy and Security Standards 4Health News:Jiangbo Pharmaceuticals to Attend the 44th China New Drugs Trade Fair in Tianjin 2Health News:Jiangbo Pharmaceuticals to Attend the 44th China New Drugs Trade Fair in Tianjin 3Health News:DaVita Named One of Best Companies to Work for in Colorado 2Health News:Bumrungrad International the first private hospital to be awarded Thailand Quality Class (TQC) for organizational excellence 2Health News:Bumrungrad International the first private hospital to be awarded Thailand Quality Class (TQC) for organizational excellence 3Health News:Homefront Diabetic Services Completes Accreditation with ACHC 2Health News:St. Gallen consensus 2009: A radically different approach to treating early breast cancer 2Health News:St. Gallen consensus 2009: A radically different approach to treating early breast cancer 3
(Date:5/17/2013)... CHAMPAIGN, Ill. , May 17, 2013  Sony Biotechnology ... Cell Sorter 8-well strip holder and 130um sorting chip.  Sony ... data collected on its new SH800 Cell Sorter, the EC800 ... during commercial tutorials at CYTO 2013, which will be held ... in San Diego, California , from May ...
(Date:5/17/2013)... 17, 2013 /PRNewswire-iReach/ -- United Medical Education, a company ... (ACLS), Pediatric Advanced Life Support (PALS) and Basic Life ... ACLS online course manuals. In order to ... to build an account with the company. By offering ... United Medical Education is setting a precedent among similar ...
(Date:5/17/2013)... 17, 2013  TechAtlas Group has announced the ... landscape map for the Chronic Kidney Disease (CKD) ... companies with drugs and devices currently on the ... sequelae. (Logo:  http://photos.prnewswire.com/prnh/20130517/NE16011LOGO ... hypertension - renal denervation , diabetic nephropathy ...
Breaking Medicine Technology:Sony Delivers New Technology for Science to CYTO 2013 2ACLS Online Course Manuals are Now Available at No Cost through United Medical Education 2TechAtlas Group Releases Innovative Chronic Kidney Disease Landscape Map 2
... to connect an infusion ... pump, and then to ... order to conduct urodynamics ... Laborie Medical Technologies infusion ...
Used for cystometry and urethral pressure profilometry. A loop is employed to enhance catheter retention and stabilization within the bladder. Supplied sterile in peel-open packages. Intended for one...
... Used for cystometry and urethral pressure ... for faster filling of the bladder ... Dual lumen catheter construction allows the ... is performed. Triple lumen catheter construction ...
... The Triage® Cardiac Panel is ... the rapid quantitative determination of ... in ethylenediaminetetraacetic acid (EDTA) whole ... test is used as an ...
Medicine Products: