Navigation Links
MicroRNAs, EMT and cancer progression
Date:3/31/2008

In the April 1 issue of G&D, a research team led by Dr. Marcus Peter (University of Chicago) identifies the microRNA miR-200 as both a powerful indicator and regulator of the epithelial phenotype of cancer cells.

EMT (the epithelial-to-mesenchymal transition) is the conversion of an epithelial cell into a mesenchymal cell. Morphologically, EMT is characterized by a loss of cell adhesion and increased cell motility. At a molecular level, it is characterized by a decreased expression of the cell adhesion molecule and epithelial marker, E-cadherin, and an increased expression of the intermediate filament protein and mesenchymal cell marker, Vimentin.

EMT is a normal embryological process, but it is implicated in various adult pathologies including cancer metastasis.

Dr. Peter and colleagues analyzed 60 different cell lines from the National Cancer Institute, representing 9 different types of human cancers, and found that miR-200 is a consistent marker of cells that express E-cadherin but lack Vimentin. This was confirmed for primary ovarian cancer.

The researchers went on to show that miR-200 targets the transcriptional repressors of E-cadherin, ZEB1 and ZEB2, and that altering miR-200 levels in established cancer cell lines induced changes consistent with either inducing EMT or the reverse process, MET. Thus, in the context of cancer progression, decreased miR-200 expression increases ZEB1/2 activity, represses E-cadherin levels, and ultimately induces EMT.

"We expected an important process of cellular differentiation such as EMT to be regulated by microRNAs but were surprised by the extraordinarily tight control of EMT by miR-200 through the ZEB proteins. Our ability to reverse EMT by reintroducing miR-200 into cancer cells gives rise to the hope that this miRNA family might be useful in reversing cancer progression" explains Dr. Peter.


'/>"/>

Contact: Heather Cosel-Pieper
coselpie@cshl.edu
Cold Spring Harbor Laboratory
Source:Eurekalert

Page: 1

Related medicine news :

1. A new way to fight cancer: the silver shield
2. Many Women Unclear About Breast Cancer Treatments
3. You May Be the Key to Cancer Prevention
4. Study finds improvement in the care of children with cancer at the end of life
5. State of Cancer Care for Nations Poor and Minorities Is Focus of Conference in Washington
6. Hit One Out of the Park for the PA Breast Cancer Coalition
7. Saving cancer patients skin
8. Mens Health Policy Center Hosts Petition to Protest Government Barrier to Prostate Cancer Medications
9. Too many women still dying from breast cancer, says charity
10. A Picture Perfect Partnership: Olympus Raises Colorectal Cancer Awareness Through eBay Giving Works Auction
11. NSAIDs: Painkillers, inflammation inhibitors, anti-cancer drugs and new de-methylating agents
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/17/2017)... ... 2017 , ... CareAcademy, a provider of specialized online training ... in seed funding to further expand its course portfolio and increase its market ... the company’s primary investors. , Founded in 2016, CareAcademy currently serves ...
(Date:8/17/2017)... ... August 17, 2017 , ... Pot Valet is a leading provider of ... city in the state, and soon, every state in the country, the company offers ... a cannabis dispensary altogether. , According to Pot Valet, all California patients ...
(Date:8/17/2017)... ... ... Media, the industry leader in digital marketing for medical practices, has been recognized as one ... the Inc. 5000 for the second time in two years. Shawn Miele, Chief Executive Officer ... for the second year in a row. It’s extremely difficult to make this list once. ...
(Date:8/17/2017)... ... August 17, 2017 , ... Finalists in the 2017 ... announced today. The awards recognize the world’s best employers and the human resources ... drive great places to work. , A diverse group of organizations and individuals ...
(Date:8/17/2017)... WA and Lighthouse Point, FL (PRWEB) , ... ... ... healthcare technology firm and Cancer Center Business Development Group, a Florida-based oncology business ... examined patient care data to quantify the dollar amount of attributable savings from ...
Breaking Medicine News(10 mins):
(Date:8/15/2017)... announced today that its fully owned USA -operating ... City Office in Yonkers, New York to ... 2 ) homecare therapy. This new East Coast location has also ... the company,s DMEPOS accreditation for Home/Durable Medical Equipment Services. ... Advanced Oxygen Therapy Inc. New York ...
(Date:8/10/2017)... , Aug. 10, 2017  Physical Rehabilitation Network (PRN), ... in Lakewood, Colorado . The reputable clinic ... Lipkin , PT, DPT with his staff of four clinicians. ... of Pittsburgh and brings over 10 years of experience with ... Belmar PT marks the 10th PRN clinic in and ...
(Date:8/7/2017)... 7, 2017 Insightin Health, provider of ... and engagement, announced the selection of Michael ... Development, effective as of February 2017. In this role, ... strategy for our clients. Wood brings with him ... and business analytics within the healthcare industry. Wood ...
Breaking Medicine Technology: