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MicroRNA variations associated with earlier prostate cancer diagnosis in African-American men
Date:4/4/2011

ssion of genes involved in tumor formation, progression, and metastasis. "miRNAs regulate gene expression. If miRNA binding sites are altered then there is a possibility that gene expression would change and could potentially contribute to the cancer process" Giri says.

Giri's team analyzed single nucleotide polymorphisms (SNPs) in miRNA binding sites in four genes of potential importance to prostate cancer risk ALOX15, IL-16, 1L-18, and RAF1 in approximately 750 men enrolled in the Prostate Cancer Risk Assessment Program at Fox Chase. None of the SNPs were associated with prostate cancer risk in Caucasian men. However, African American men who carried a genetic variant in the miRNA binding site in the IL-16 gene had a 2.27-fold increased risk of early diagnosis, compared with African American men who did not carry the variant. The association was statistically significant (p=0.013).

Additionally, African American men who carried a variant in the miRNA binding site in the IL-18 gene had a 4.44-fold increased risk of early diagnosis, compared with men who did not. Giri cautions, though, that this association had a relatively weak statistical association (p=0.042) and needs to be followed up in a larger study.

"Our goal is to develop individualized prostate cancer screening approaches, particularly for high-risk men," Giri says. "Therefore, our research is focused on identifying which men may develop lethal or clinically meaningful prostate cancer in order to screen these men for benefit, while sparing other men unnecessary tests and procedures. Down the road, these new markers may help us do that."


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Contact: Diana Quattrone
Diana.Quattrone@fccc.edu
215-728-7784
Fox Chase Cancer Center
Source:Eurekalert

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