Navigation Links
MicroRNA variations associated with earlier prostate cancer diagnosis in African-American men
Date:4/4/2011

ORLANDO, FL (April 4, 2011) Prostate cancer is the second leading cause of cancer-related death among American men. Yet population-wide screening programs have not reduced the number of deaths from the disease. By focusing screening programs on the men who are at greatest risk for aggressive disease or diagnosis at a young age, researchers think they could improve mortality rates and personalize the screening approach. For that reason, scientists have been looking for genetic markers to help them identify exactly which men are at high risk and require regular screening. Now, Fox Chase Cancer Center researchers have found that two novel genetic markers are associated with earlier time to prostate cancer diagnosis among African American menand the markers are in a part of the genome that has only recently come under scientific study.

Veda Giri, MD, medical oncologist and director of Prostate Cancer Risk Assessment at Fox Chase, will present the findings at the AACR 102nd Annual Meeting 2011 on Monday, April 4.

Small RNAs, called microRNAs (miRNAs), help regulate gene activity. And expression of these miRNAs can influence an individual's risk of cancer. Knowing this, Giri and her colleagues have been researching genetic variations in miRNA binding sites. In two genes, IL-16 and IL-18, they have now found variations associated with a two-fold or greater increased risk of early prostate cancer diagnosis in African American men who are undergoing screening.

"We have found some preliminary data supporting the idea that genetic variation in miRNA target sites can influence prostate cancer risk," says Giri. "If we confirm these data, then we might be able to use these sites, along with other known genetic variants, to help individualize prostate screening in the future."

Giri notes that although miRNAs were only discovered recently, their role in cancer susceptibility is being rapidly uncovered, probably because they control expression of genes involved in tumor formation, progression, and metastasis. "miRNAs regulate gene expression. If miRNA binding sites are altered then there is a possibility that gene expression would change and could potentially contribute to the cancer process" Giri says.

Giri's team analyzed single nucleotide polymorphisms (SNPs) in miRNA binding sites in four genes of potential importance to prostate cancer risk ALOX15, IL-16, 1L-18, and RAF1 in approximately 750 men enrolled in the Prostate Cancer Risk Assessment Program at Fox Chase. None of the SNPs were associated with prostate cancer risk in Caucasian men. However, African American men who carried a genetic variant in the miRNA binding site in the IL-16 gene had a 2.27-fold increased risk of early diagnosis, compared with African American men who did not carry the variant. The association was statistically significant (p=0.013).

Additionally, African American men who carried a variant in the miRNA binding site in the IL-18 gene had a 4.44-fold increased risk of early diagnosis, compared with men who did not. Giri cautions, though, that this association had a relatively weak statistical association (p=0.042) and needs to be followed up in a larger study.

"Our goal is to develop individualized prostate cancer screening approaches, particularly for high-risk men," Giri says. "Therefore, our research is focused on identifying which men may develop lethal or clinically meaningful prostate cancer in order to screen these men for benefit, while sparing other men unnecessary tests and procedures. Down the road, these new markers may help us do that."


'/>"/>

Contact: Diana Quattrone
Diana.Quattrone@fccc.edu
215-728-7784
Fox Chase Cancer Center
Source:Eurekalert

Related medicine news :

1. Protein and microRNA block cellular transition vital to metastasis
2. MicroRNAs could increase the risk of amputation in diabetics
3. MicroRNA-TP53 circuit connected to chronic lymphocytic leukemia
4. MicroRNA controls mammary gland development in mice
5. Caltech biologists discover microRNAs that control function of blood stem cells
6. MicroRNA molecule increases number of blood stem cells, may help improve cancer treatment
7. Cancer cells show rewired, fragmented microRNA networks
8. Study links microRNA to shut-down of DNA-repair genes
9. Scientists identify microRNA as possible cause of chemotherapy resistance
10. ICUROS study finds international variations in quality of life loss after fracture
11. Chromosomal variations found in early passage female embryonic stem cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/20/2017)... ... 20, 2017 , ... Chuck E. Cheese’s® and Center for Autism and Related ... Chuck E. Cheese’s locations throughout New England, New York and New Jersey to provide ... the fun of visiting Chuck E. Cheese’s in a sensory-friendly environment. , After ...
(Date:2/19/2017)... ... February 19, 2017 , ... The Citadel’s new Swain Department ... being led by Amelia Joseph, Ph.D. Joseph was engaged by the college as a ... department in early 2016. After a nation-wide search, she was selected to head the ...
(Date:2/19/2017)... ... February 19, 2017 , ... ... result in better care, and MEDfx and the Delaware Health Information Network (DHIN) ... , As the nation’s first state-wide health information exchange, DHIN stores and shares ...
(Date:2/18/2017)... Waltham, Massachusetts (PRWEB) , ... February 17, 2017 ... ... be the leading source of disruptive innovation in the industry, according to the ... Insights Reports are based on surveys of the NEJM Catalyst Insights Council, a ...
(Date:2/18/2017)... ... February 17, 2017 , ... Park Cities Pet Sitter President, Joette White, ... Pet Life Radio network. The episode, which was posted this week, features a ... factors led to Park Cities Pet Sitter’s being awarded the 2017 National Association of ...
Breaking Medicine News(10 mins):
(Date:2/19/2017)... Feb. 19, 2017   AC Group Inc. , ... ranking of vendors in the PMS/EHR healthcare marketplace, will ... system requirements to succeed in this ecosystem at HIMSS,17. ... together information obtained from over 200 ACOs, compared and ... and services companies that are providing different pieces of ...
(Date:2/19/2017)... , February 18, 2017 Marapharm ... to purchase a Medical Delivery Service with the specific ... transactions between qualified patients and caregivers. The delivery service ... located in the Coachella Valley, California ... Los Angeles area to the West, population ...
(Date:2/18/2017)... Feb. 17, 2017   Parker Waichman ... the rights of victims injured by medical devices, ... to call for better reporting. Congress required hospitals ... Safety concerns involving power morcellators and duodenoscopes prompted ... investigate how hospitals report injuries and deaths related ...
Breaking Medicine Technology: