Navigation Links
MicroRNA that could be used to suppress prostate cancer progression found
Date:5/16/2014

CINCINNATIAbout one in seven men will develop prostate cancer over the course of a lifetime, and about one in 36 men will die from it.

This is why findings by Cincinnati Cancer Center researchers, showing that a tumor suppressive microRNA, when activated by an anti-estrogen drug, could contribute to development of future targeted therapies, are important.

These findings are published in the May 16, 2014 edition of the journal PLOS ONE.

"MicroRNAs, or miRNAs, are short RNA molecules that play a prominent role in regulating gene expression. One miRNA can target multiple genes, but their expression is often hijacked by cancer cells and disrupts multiple cancer-causing or tumor-suppressing pathways," says Shuk-Mei Ho, PhD, director of the CCC and Jacob G. Schmidlapp Chair of Environmental Health and professor at the University of Cincinnati (UC) College of Medicine.

She along with Ricky Y.K. Leung, PhD, member of the CCC, assistant research professor in the department of environmental health and member of the UC Cancer Institute, and their team identified a new miRNA, known as hsa-miR-765, which is specifically activated by a Food and Drug Administration (FDA)-approved anti-estrogen drug (fulvestrant).

"This miRNA suppresses expression of HMGA1, a gene that was shown in previous studies to be associated with prostate cancer progression and recurrence," says Leung. "These findings do not only contribute to new insights on the effects of anti-estrogen but also the potential of using miRNA for monitoring drug efficacy and for future RNA-based therapy developments.

"This study also highlights the potential use of this anti-estrogen or miRNA in patients with recurrent prostate cancer, for whom there is no treatment, and raises the possibility of using anti-estrogen or miRNA treatments in preventing or slowing progression for primary prostate cancer."

Using cultured prostate cancer specimens fro
'/>"/>

Contact: Katie Pence
katie.pence@uc.edu
513-558-4561
University of Cincinnati Academic Health Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. MicroRNA could be key target for bowel cancer treatment
2. Fruit fly microRNA research at Rutgers-Camden offers clues to aging process
3. Viral microRNAs responsible for causing AIDS-related cancer, new USC study shows
4. Wayne State to study role of microRNAs in prostate cancer racial disparities
5. MicroRNA-31 might predict lung-cancer spread
6. Versatile microRNAs choke off cancer blood supply, suppress metastasis
7. Loss of MicroRNA decoy might contribute to development of soft-tissue sarcoma
8. New papers identify a microRNA that drives both cancer onset and metastasis
9. Moffitt Cancer Center researchers say 1 specific microrna promotes tumor growth and cancer spread
10. Atherosclerosis: Specific microRNAs promote inflammation
11. MicroRNA molecule may serve as biomarker, target for brain metastases in breast cancer patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/5/2015)... ... July 05, 2015 , ... Doctors at the Swedish Cancer Institute in ... one day change the outlook for people with pleural mesothelioma. Surviving Mesothelioma has just ... Researchers report that five mesothelioma patients treated with 25Gy of radiation over five days ...
(Date:7/4/2015)... ... 2015 , ... When a hacker gains access to someone’s email account, it can lead to ... July 1st, the FTC issued a scam alert about a social engineering scam ... a password reset instigated by the hacker. All they have to do is click ...
(Date:7/3/2015)... ... , ... On June 30th SEO authority and veteran Internet ... "Page One Engine" . The program, which has been hailed as the ... well-known marketers. HonestyFirstReviews.com's Tiffany Hendricks has joined the party, publishing an in-depth review ...
(Date:7/3/2015)... ... July 03, 2015 , ... B. ... has been retained to lead a national president recruitment for Regional ... the healthcare industry, B. E. Smith has recently placed more than 1,000 healthcare ...
(Date:7/3/2015)... Louis, MO (PRWEB) , ... July 03, 2015 , ... ... responsive website to replace their existing Talcum Powder Cancer Lawsuit Center website. Just as ... talcum powder lawsuit news , offering timely lawsuit updates and ovarian cancer warning ...
Breaking Medicine News(10 mins):Health News:New Mesothelioma Study Calls IMRT/Surgery Combo “Innovative and Promising”, According to Surviving Mesothelioma 2Health News:New FTC Scam Alert Shows Latest Example of Social Engineering Dangers 2Health News:New FTC Scam Alert Shows Latest Example of Social Engineering Dangers 3Health News:New FTC Scam Alert Shows Latest Example of Social Engineering Dangers 4Health News:Page One Engine - Review Of Dori Friend's SEO Training Course Released 2Health News:Regional Care, Inc. Retains B. E. Smith to Recruit New President 2Health News:Regional Care, Inc. Retains B. E. Smith to Recruit New President 3Health News:Talcum Powder Lawsuit News: Cancer Attorneys Launch Updated Mobile Site 2Health News:Talcum Powder Lawsuit News: Cancer Attorneys Launch Updated Mobile Site 3
... CMS Training Program,To Address Federal Regulator’s New Marketing Compliance Guidelines ... ... 8, 2008 -- Connextions Inc. announced today that ... intensive training program for its in-house licensed insurance agents in ...
... Growing Number of Measures Helping Those Suffering,from Mental Illness, ... making it,easier for someone with a severe mental illness ... Governor Bobby Jindal on,June 21, 2008. The law, which ... year, will take effect on August 15., "Nicola,s ...
... Need for Parents to Include Life Insurance ... in Their College-Funding Plans, ARLINGTON, ... -- turns. When a loved one dies, it can be particularly,painful. ... that comes when the head of the household dies,prematurely with little ...
... people suffer from preventable, treatable diseases around,the world, ... Global Health Progress, TOYAKO, Japan, July 8 ... Health Organization (WHO) and,the Drugs for Neglected Diseases ... the importance of neglected diseases as a global ...
... An economist examining the,proposed merger of Highmark, Inc. ... companies would have a market share far greater,than ... presented to the,Pennsylvania Insurance Department today in Pittsburgh ... International, the proposed merger,would result in a combined ...
... the most complex and challenging mental disorder in the ... and longterm treatment needs and may be associated in ... burden for both the individual and family. It is ... clinically severe mood disorder. The disorder is called bipolar, ...
Cached Medicine News:Health News:Connextions Inc. Works to Ensure CMS Compliance for Medicare Advantage Plan Providers 2Health News:Connextions Inc. Works to Ensure CMS Compliance for Medicare Advantage Plan Providers 3Health News:Louisiana Improves Law for Treating Mentally Ill 2Health News:LIFE Foundation Asks Public to Vote to Determine its $5,000 Life Lessons College Scholarship Winner 2Health News:LIFE Foundation Asks Public to Vote to Determine its $5,000 Life Lessons College Scholarship Winner 3Health News:Global Health Progress Joins WHO and DNDi to Call For Increased Commitments to Fighting Neglected Tropical Diseases 2Health News:Economist Finds Highmark/IBC Merger Would Result in 70 Percent Share in Pennsylvania, Far Higher Than Initial Reports 2Health News:The ECNP consensus statement on bipolar depression 2
(Date:7/2/2015)... 2, 2015  Fort Lauderdale-based investment banking firm, ... that its Consumer Group completed the sale of ... plc (ISE: KRZ) ("Kerry"), one of the leading ... as well as functional ingredients and actives for ... Turner served as the exclusive financial advisor to ...
(Date:7/2/2015)... DALLAS , July 2, 2015 ... Market by Technology (Deep Brain Stimulation, Spinal Cord Stimulation, Transcranial ... Trends & Global Forecast to 2020", published by MarketsandMarkets, the ... and is projected to reach $6.20 Billion by 2020, at ... Browse 8 4 market ...
(Date:7/2/2015)... -- The Green Exchange, Inc., the developer,s of "Loud Cannabis" ... app that connects cannabis growers directly to patients to ... that their service provides the fastest delivery on the ... half a dozen other delivery apps that have popped ... in that it connects growers directly with patients. ...
Breaking Medicine Technology:Farlie Turner's Consumer Group Completes Sale of Insight Beverages to Kerry 2Neuromodulation Market Worth $6.20 Billion by 2020 2Neuromodulation Market Worth $6.20 Billion by 2020 3Neuromodulation Market Worth $6.20 Billion by 2020 4New Cannabis Delivery App Gets Product to Patient in Under 7 Minutes 2
... SNY ) announced today that it has submitted ... ) in an all-cash transaction valued at approximately $18.5 billion. ... Genzyme shareholders would receive $69 per Genzyme share in cash, ... $49.86 on July 1, 2010. Sanofi-aventis, offer also represents a ...
... Inc. Magazine/Inc.com selects online retail company PainReliever.com (Pain Relievers, ... in the United States. PainReliever.com is owned by Norris ... that a store from Norris E-Commerce Management has won ... was awarded as an Inc. 5000 recipient. ...
Cached Medicine Technology:Sanofi-aventis Announces Non-Binding Offer to Acquire Genzyme 2Sanofi-aventis Announces Non-Binding Offer to Acquire Genzyme 3Sanofi-aventis Announces Non-Binding Offer to Acquire Genzyme 4Sanofi-aventis Announces Non-Binding Offer to Acquire Genzyme 5Sanofi-aventis Announces Non-Binding Offer to Acquire Genzyme 6Sanofi-aventis Announces Non-Binding Offer to Acquire Genzyme 7Sanofi-aventis Announces Non-Binding Offer to Acquire Genzyme 8PainReliever.com Earns Inc. 5000 Award 2
... Instruments were developed in surgeon's desire to ... having an instrument with the strength to ... of the bending or breaking. Arthrotek Hand ... conform to the surgeon's hand. This new ...
... Precision Hand Instruments were developed in surgeon's ... while still having an instrument with the ... the fear of the bending or breaking. ... manufactured to conform to the surgeon's hand. ...
... ACL Instrumentation System has been developed ... of anterior cruciate ligament (ACL) reconstruction ... Instrumentation system and endoscopic surgical technique, ... reproducible anatomical graft placement and stable ...
... Simplicity with Clinical Lab Accuracy ... used as an accurate screen ... breath tests. In clinical trials, ... the Q.E.D.® demonstrated high correlation ...
Medicine Products: