Navigation Links
MicroRNA that could be used to suppress prostate cancer progression found
Date:5/16/2014

CINCINNATIAbout one in seven men will develop prostate cancer over the course of a lifetime, and about one in 36 men will die from it.

This is why findings by Cincinnati Cancer Center researchers, showing that a tumor suppressive microRNA, when activated by an anti-estrogen drug, could contribute to development of future targeted therapies, are important.

These findings are published in the May 16, 2014 edition of the journal PLOS ONE.

"MicroRNAs, or miRNAs, are short RNA molecules that play a prominent role in regulating gene expression. One miRNA can target multiple genes, but their expression is often hijacked by cancer cells and disrupts multiple cancer-causing or tumor-suppressing pathways," says Shuk-Mei Ho, PhD, director of the CCC and Jacob G. Schmidlapp Chair of Environmental Health and professor at the University of Cincinnati (UC) College of Medicine.

She along with Ricky Y.K. Leung, PhD, member of the CCC, assistant research professor in the department of environmental health and member of the UC Cancer Institute, and their team identified a new miRNA, known as hsa-miR-765, which is specifically activated by a Food and Drug Administration (FDA)-approved anti-estrogen drug (fulvestrant).

"This miRNA suppresses expression of HMGA1, a gene that was shown in previous studies to be associated with prostate cancer progression and recurrence," says Leung. "These findings do not only contribute to new insights on the effects of anti-estrogen but also the potential of using miRNA for monitoring drug efficacy and for future RNA-based therapy developments.

"This study also highlights the potential use of this anti-estrogen or miRNA in patients with recurrent prostate cancer, for whom there is no treatment, and raises the possibility of using anti-estrogen or miRNA treatments in preventing or slowing progression for primary prostate cancer."

Using cultured prostate cancer specimens fro
'/>"/>

Contact: Katie Pence
katie.pence@uc.edu
513-558-4561
University of Cincinnati Academic Health Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. MicroRNA could be key target for bowel cancer treatment
2. Fruit fly microRNA research at Rutgers-Camden offers clues to aging process
3. Viral microRNAs responsible for causing AIDS-related cancer, new USC study shows
4. Wayne State to study role of microRNAs in prostate cancer racial disparities
5. MicroRNA-31 might predict lung-cancer spread
6. Versatile microRNAs choke off cancer blood supply, suppress metastasis
7. Loss of MicroRNA decoy might contribute to development of soft-tissue sarcoma
8. New papers identify a microRNA that drives both cancer onset and metastasis
9. Moffitt Cancer Center researchers say 1 specific microrna promotes tumor growth and cancer spread
10. Atherosclerosis: Specific microRNAs promote inflammation
11. MicroRNA molecule may serve as biomarker, target for brain metastases in breast cancer patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/18/2014)... one of the most distinguished bamboo product suppliers in the ... floorings to its website. For additional information, the firm ... to 29 percent off. , BamboofloorChina.com has a wide ... of the company’s experts have been working in the industry ... of elegant bamboo products on its website; all of them ...
(Date:10/18/2014)... European College of Neuropsychopharmacology (ECNP) is pleased to announce ... is Dick Swaab, for his book, We are our ... the ECNP Media Award recognises outstanding contributions to destigmatising ... prize of € 5,000. , The ECNP Media Award ... promote a better understanding of the complexity and impact ...
(Date:10/18/2014)... (PRWEB) October 18, 2014 One major ... government and NGO initiatives, which are making efforts to ... reimbursement policies make the organ donation process more transparent ... Preservation Solutions market to grow at a CAGR ... the report, one of the major drivers in the ...
(Date:10/18/2014)... 18, 2014 For the second time in ... on cyber security risks facing US businesses. On September ... by disgruntled or former employees. And now, according to ... issued a flash warning for US businesses about possible cyber ... actors who routinely steal high-value information.” , “With the ...
(Date:10/18/2014)... Wright & Schulte LLC has filed an Actos ... developed bladder cancer after using Actos to treat ... Pharmaceuticals America, Inc., states that the Nebraska man was ... long-term maintenance of his diabetes. In March 2011, the ... Actos complaint. The Actos claim contended that as a ...
Breaking Medicine News(10 mins):Health News:Brand New Bamboo Floorings Now Unveiled By BamboofloorChina.com, A Distinguished Supplier In The Market 2Health News:Dick Swaab wins the 2014 ECNP Media Award 2Health News:Organ Preservation Solutions Market to Grow at 16.85% CAGR to 2018 Forecast a New Research Report at Sandlerresearch.org 2Health News:Organ Preservation Solutions Market to Grow at 16.85% CAGR to 2018 Forecast a New Research Report at Sandlerresearch.org 3Health News:Organ Preservation Solutions Market to Grow at 16.85% CAGR to 2018 Forecast a New Research Report at Sandlerresearch.org 4Health News:Another FBI Cyber Attack Warning for US Businesses 2Health News:Another FBI Cyber Attack Warning for US Businesses 3Health News:Another FBI Cyber Attack Warning for US Businesses 4Health News:Actos Lawsuits Continue To Be Filed By Wright & Schulte LLC Contending Development of Bladder Cancer After Taking Type Two Diabetes Medication 2Health News:Actos Lawsuits Continue To Be Filed By Wright & Schulte LLC Contending Development of Bladder Cancer After Taking Type Two Diabetes Medication 3Health News:Actos Lawsuits Continue To Be Filed By Wright & Schulte LLC Contending Development of Bladder Cancer After Taking Type Two Diabetes Medication 4
... Mothers Against Drunk Driving (MADD) New York delivered ... showing support for MADD,s Campaign to Eliminate to ... )A key part of MADD,s Campaign to ... the New York State legislature that would expand ...
... Early findings about the emerging pandemic of a new strain ... Science . , Researchers from the MRC Centre ... in collaboration with the World Health Organisation and public health ... the end of April. Their key findings are as follows: ...
... AUSTIN, Texas, May 11 The Texas Cardiac Arrhythmia ... more than 2,300 patients with heart rhythm disorders since ... fourth of them from outside Central Texas."In just one ... Institute at St. David,s Medical Center, coupled with our ...
... 11 One year after an 8.0 magnitude ... an estimated 5 million houses in southwest China, ... of recovery. The focus has shifted from putting ... to constructing more permanent, earthquake-resistant homes and helping ...
... military veteran who passed away from ALS (amyotrophic lateral sclerosis) have placed ... by The ALS Association. , ... Calabasas Hills, CA (Vocus) May 11, ... military veteran who passed away from ALS (amyotrophic lateral sclerosis) have placed ...
... College of Medical Genetics Foundation (ACMGF) has announced the ... meeting. The board members are active participants in serving ... policies and programs of the ACMGF.The incoming directors, who ... W. Grody, M.D., Ph.D., FACMG , Professor in the ...
Cached Medicine News:Health News:MADD Delivers Nearly 7,000 Petitions to Governor Paterson Urging Ignition Interlocks For All Convicted DWI Offenders 2Health News:Swine flu: Early findings about pandemic potential reported in new study 2Health News:Texas Cardiac Arrhythmia Institute at St. David's Medical Center Celebrates Successful First Year 2Health News:Texas Cardiac Arrhythmia Institute at St. David's Medical Center Celebrates Successful First Year 3Health News:Texas Cardiac Arrhythmia Institute at St. David's Medical Center Celebrates Successful First Year 4Health News:The Red Cross is Helping to Build More Than 100,000 Houses One Year After the Sichuan Earthquake 2Health News:Military Veterans Struck Down by Lou Gehrig's Disease Honored on Mother's Day by The ALS Association with Wreath Laying Ceremony at Arlington National Cemetery 2Health News:New Board Members Join American College of Medical Genetics Foundation (ACMGF): Distinguished Executive, Medical and Philanthropic Leaders Bring Additional Perspectives to the ACMGF Board 2Health News:New Board Members Join American College of Medical Genetics Foundation (ACMGF): Distinguished Executive, Medical and Philanthropic Leaders Bring Additional Perspectives to the ACMGF Board 3
(Date:10/16/2014)... -- DaVita HealthCare Partners Inc. (NYSE: DVA ) announced ... discuss third quarter results on Thursday, Nov. 6, 2014, at ... results after market close the same day. ... at the DaVita HealthCare Partners IR web page. You can ... 6, 2014 Starting at 5:00 p.m. EST Dial ...
(Date:10/16/2014)... -- Curtis & Coulter LLC, a new specialty life ... their co-located Bioequivalence: Intersection Between Science & Regulatory ... taking place on November 5-6 2014 at the ... November,s events are specifically designed to unify and ... process, as well as optimizing formulation development approaches for ...
(Date:10/16/2014)... 16, 2014  Eli Lilly and Company (NYSE: ... a sale of one of its three manufacturing plants in ... in Guayama, Puerto Rico , will remain ... approximately 100 full-time non-contracted employees currently working in Guayama will ... ) location. "The decision to conclude ...
Breaking Medicine Technology:DaVita HealthCare Partners Inc. Schedules 3rd Quarter 2014 Investor Conference Call 2Simplifying the Bioequivalence Testing Process and Optimizing Oral Formulation Development via Unifying the Global Life Science Community this November in San Diego 2Lilly Announces Plan to Realign Puerto Rico Manufacturing Operations 2Lilly Announces Plan to Realign Puerto Rico Manufacturing Operations 3
Button shape tip, round serrated handle, dull finish, overall length 130 mm....
... EX is a rigid gas lens with ... specific characteristics as hard contact lens, it ... excellent performance against astigmatism. The key feature ... combination of fluoromethacrylate, Siloxanylmethacrylate and methacrylic acid, ...
Magniclear is the first presbyopic lens to combine the clear distance optics of a spherical lens, the intermediate visual performance of a multifocal and the predictably crisp, near power of a bifoca...
Boston Multivision design is manufactured in Boston ES material for early presbyope patients. Boston Multivision lens provides crisp, clear vision at near, intermediate, and far distances and excelle...
Medicine Products: