Navigation Links
MicroRNA that blocks bone destruction could offer new therapeutic target for osteoporosis
Date:6/25/2014

This condition disproportionately affects seniors and women, and leads to more than 1.5 million fractures annually.

miR-34a could have an additional therapeutic application, offering protection from bone metastases in a variety of cancers, Dr. Wan noted. Bone metastases happen when cancer cells travel from the primary tumor site to the bone, establishing a new cancer location. Researchers saw that injecting the miR-34a mimic in mice could prevent the metastasis of breast and skin cancer cells specifically to bone, mainly by disarming the metastatic niche in bone.

Co-author Dr. Joshua Mendell, Professor of Molecular Biology at UTSouthwestern and member of the UTSouthwestern Harold C. Simmons Cancer Center, noted that his laboratory previously showed that miR-34a can directly suppress the growth of cancer cells.

"We were very excited to see, through this collaborative work with Dr. Wan's group, that miR-34a can also suppress bone metastasis. Thus, miR-34a-based therapy could provide multiple benefits for cancer patients," said Dr. Mendell, CPRIT Scholar in Cancer Research. CPRIT is the Cancer Prevention and Research Institute of Texas, which provides voter-approved state funds for groundbreaking cancer research and prevention programs and services in Texas.


'/>"/>

Contact: Russell Rian
russell.rian@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Why inflammation leads to a leaky blood-brain barrier: MicroRNA-155
2. Wound-healing role for microRNAs in colon offer new insight to inflammatory bowel diseases
3. MicroRNA that could be used to suppress prostate cancer progression found
4. MicroRNA could be key target for bowel cancer treatment
5. Fruit fly microRNA research at Rutgers-Camden offers clues to aging process
6. Viral microRNAs responsible for causing AIDS-related cancer, new USC study shows
7. Wayne State to study role of microRNAs in prostate cancer racial disparities
8. MicroRNA-31 might predict lung-cancer spread
9. Versatile microRNAs choke off cancer blood supply, suppress metastasis
10. Loss of MicroRNA decoy might contribute to development of soft-tissue sarcoma
11. New papers identify a microRNA that drives both cancer onset and metastasis
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
MicroRNA that blocks bone destruction could offer new therapeutic target for osteoporosis
(Date:12/19/2014)... B. E. Smith, the only full-service leadership ... retained to lead a national chief financial officer ... The top executive search firm in the healthcare industry, ... healthcare executives into organizations. , Johnson Memorial Hospital ... to the residents of Johnson County and the surrounding ...
(Date:12/19/2014)... If you have ever been unable ... probably wished you had an arsenal of treatments to ... and other breathing disorders. Currently, the only proven methods ... but other common treatments do exist. At the ... Antonio, TX, 34 asthma educators responded to a Harmonica ...
(Date:12/19/2014)... (PRWEB) December 19, 2014 Consilium ... at the AMSUS Society for Federal Health Professionals ... locum tenens industry to military and federal healthcare ... the National Veterans Small Business Engagement (NVSBE) conference ... continues to be a vital solution in addressing ...
(Date:12/19/2014)... Amy Norton HealthDay Reporter ... moms who were exposed to high levels of air pollution ... autism, a U.S. study suggests. Researchers found that of ... 2002, those exposed to the most air pollution during pregnancy ... developed autism. And exposure during the third trimester, specifically, showed ...
(Date:12/17/2014)... 2014 While countless companies tempt patients to ... the potential dangers of their purchase. Not only is the ... qualified doctor, but patients who buy hCG online are typically ... is actually no real hCG present. Illegal internet hCG is ... no safety standards and may contain unknown fillers that can ...
Breaking Medicine News(10 mins):Health News:Johnson Memorial Hospital Retains B. E. Smith to Recruit New Chief Financial Officer 2Health News:Johnson Memorial Hospital Retains B. E. Smith to Recruit New Chief Financial Officer 3Health News:Harmonica Techs, Inventors of the Pulmonica®, Unveil New Findings on Complementary Treatments for Asthma 2Health News:Harmonica Techs, Inventors of the Pulmonica®, Unveil New Findings on Complementary Treatments for Asthma 3Health News:Consilium Staffing Increasing Awareness of Locum Tenens through Conference Appearances 2Health News:Smog Exposure During Pregnancy Linked to Autism Risk 2Health News:Smog Exposure During Pregnancy Linked to Autism Risk 3Health News:Diet Doc Reveals the Real Dangers for Those who Buy hCG Online 2Health News:Diet Doc Reveals the Real Dangers for Those who Buy hCG Online 3
... More than eight out of 10 homeless people surveyed ... least one chronic health condition and more than half have ... they live in unsafe, unstable or unaffordable housing--had equally poor, ... The underlying cause for these health issues is poverty, said ...
... By Serena Gordon HealthDay Reporter , TUESDAY, ... as nuts, to your diet can lower your cholesterol more ... Foods with plant sterols also have known cholesterol-reducing properties, and ... cholesterol by more than 13 percent. A low-fat diet alone ...
... , New York, NY, August 24, 2011 Nearly three-quarters (72%) ... their jobs over the last two years said that they ... because of cost, according to a new Commonwealth Fund ... or medical debt, compared to about half (49%) who lost ...
... Aug. 23 (HealthDay News) -- Accidental exposure to highly ... the United States, a new study finds. Researchers ... in outpatient chemotherapy infusion centers and found that nearly ... exposed to the drugs. In the United States, ...
... , TUESDAY, Aug. 23 (HealthDay News) -- ... appears to worsen over time and may lead to an ... people with diastolic dysfunction, which often comes with advancing age, ... abnormal way and is accompanied by elevated filling pressures. ...
... August 23, 2011 In a joint research effort ... with help from scientists at The University of Pennsylvania, ... Health, investigators from the Florida campus of The Scripps ... allows cells to rid themselves of damaged mitochondria, which ...
Cached Medicine News:Health News:Study: 85 percent of homeless people have chronic health conditions 2Health News:Certain Foods Said to Help Lower Bad Cholesterol 2Health News:Certain Foods Said to Help Lower Bad Cholesterol 3Health News:Three quarters of those who have lost jobs and health insurance are skipping needed health care 2Health News:Three quarters of those who have lost jobs and health insurance are skipping needed health care 3Health News:Three quarters of those who have lost jobs and health insurance are skipping needed health care 4Health News:Nurses at Risk for Accidental Exposure to Chemo Drugs: Study 2Health News:Common Heart Dysfunction Can Help Bring on Heart Failure 2Health News:Scripps Research scientists define cellular pathway essential to removing damaged mitochondria 2
(Date:12/19/2014)... INDIANAPOLIS and LYON, France ... (NYSE: LLY ) and Adocia (Euronext Paris: ... focused on developing an ultra-rapid insulin, known as BioChaperone ... type 2 diabetes. BioChaperone Lispro relies on Adocia,s proprietary ... Lilly and Adocia will develop BioChaperone Lispro ...
(Date:12/17/2014)... 2014 Los beneficios y ganancias ... nivel de gasto en investigación y desarrollo   ... 30 de septiembre de 2014) ZEISS aumentó sus ingresos ... euros (año anterior: 4.190 millones de euros) a pesar ... (EBIT) crecieron un 14 por ciento, a 360 millones ...
(Date:12/17/2014)... 2014  Northstar Global Business Services, Inc. (OTCPink:MDIN) ... has made their final decision and has determined ... stock effective December 15, 2014, and has resumed ... and book entry transfer services. All deposit restrictions have ... again fully "DTC Eligible", and has resumed electronic ...
Breaking Medicine Technology:Lilly and Adocia Announce Alliance to Co-Develop Ultra-Rapid Insulin Based on BioChaperone Technology 2Lilly and Adocia Announce Alliance to Co-Develop Ultra-Rapid Insulin Based on BioChaperone Technology 3ZEISS confirma su posición en un entorno difícil 2Northstar announces that the DTC chill on MDIN has been officially lifted 2Northstar announces that the DTC chill on MDIN has been officially lifted 3
... Target Patients for ALIMTA(R), (pemetrexed for injection) ... Cancer, BARCELONA, Spain, Sept. 25 ... lung cancer (NSCLC) that,are classified as having ... when treated in the second-line setting with,ALIMTA(R) ...
... Mich. Sept. 24 Velcura Therapeutics, Inc., a,biotechnology ... the,U.S. Food and Drug Administration (FDA) Sept. 20 ... VEL-0230, a drug developed to treat bone,disease. The ... was to obtain feedback from the FDA,s Division ...
Cached Medicine Technology:Studies Suggest Key Correlation Between Lung Cancer Subtype and Treatment Outcomes 2Studies Suggest Key Correlation Between Lung Cancer Subtype and Treatment Outcomes 3Studies Suggest Key Correlation Between Lung Cancer Subtype and Treatment Outcomes 4Studies Suggest Key Correlation Between Lung Cancer Subtype and Treatment Outcomes 5Studies Suggest Key Correlation Between Lung Cancer Subtype and Treatment Outcomes 6Studies Suggest Key Correlation Between Lung Cancer Subtype and Treatment Outcomes 7Studies Suggest Key Correlation Between Lung Cancer Subtype and Treatment Outcomes 8Velcura Therapeutics, Inc. Reports Positive Pre-IND Meeting With FDA and Plans Early Clinical Trials for New Drug to Treat Multiple Myeloma Bone Disease 2Velcura Therapeutics, Inc. Reports Positive Pre-IND Meeting With FDA and Plans Early Clinical Trials for New Drug to Treat Multiple Myeloma Bone Disease 3
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: