Navigation Links
MicroRNA that blocks bone destruction could offer new therapeutic target for osteoporosis
Date:6/25/2014

DALLAS June 25, 2014 UTSouthwestern cancer researchers have identified a promising molecule that blocks bone destruction and, therefore, could provide a potential therapeutic target for osteoporosis and bone metastases of cancer.

The molecule, miR-34a, belongs to a family of small molecules called microRNAs (miRNAs) that serve as brakes to help regulate how much of a protein is made, which in turn, determines how cells respond.

UTSouthwestern researchers found that mice with higher than normal levels of miR-34a had increased bone mass and reduced bone breakdown. This outcome is achieved because miR-34a blocks the development of bone-destroying cells called osteoclasts, which make the bone less dense and prone to fracture.

"This new finding may lead to the development of miR-34a mimics as a new and better treatment for osteoporosis and cancers that metastasize to the bone," said senior author Dr. Yihong Wan, Assistant Professor of Pharmacology and member of the UTSouthwestern Harold C. Simmons Cancer Center.

Her team found that injecting nanoparticles containing an artificial version, or mimic, of miR-34a into a mouse with post-menopausal osteoporosis decreased bone loss. "Interestingly, the mouse miR-34a is identical to that in humans, which means that our findings may apply to humans as well," said Dr. Wan, Virginia Murchison Linthicum Scholar in Medical Research at UTSouthwestern.

The study is published online in the journal Nature.

High levels of bone destruction and reduced bone density caused by excessive osteoclasts are characteristic of osteoporosis, a common bone disease in which bones become fragile and susceptible to fracture.
'/>"/>

Contact: Russell Rian
russell.rian@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Why inflammation leads to a leaky blood-brain barrier: MicroRNA-155
2. Wound-healing role for microRNAs in colon offer new insight to inflammatory bowel diseases
3. MicroRNA that could be used to suppress prostate cancer progression found
4. MicroRNA could be key target for bowel cancer treatment
5. Fruit fly microRNA research at Rutgers-Camden offers clues to aging process
6. Viral microRNAs responsible for causing AIDS-related cancer, new USC study shows
7. Wayne State to study role of microRNAs in prostate cancer racial disparities
8. MicroRNA-31 might predict lung-cancer spread
9. Versatile microRNAs choke off cancer blood supply, suppress metastasis
10. Loss of MicroRNA decoy might contribute to development of soft-tissue sarcoma
11. New papers identify a microRNA that drives both cancer onset and metastasis
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
MicroRNA that blocks bone destruction could offer new therapeutic target for osteoporosis
(Date:8/1/2014)... 01, 2014 Parker Waichman LLP, a ... victims injured by defective medical devices and drugs reports ... its Ethicon surgical power morcellator devices used for the ... involving the spread of cancer associated with power morcellators, ... 31, 2014. , Johnson & Johnson had previously ...
(Date:8/1/2014)... a first-of-its-kind study, researchers at University Hospitals Rainbow Babies ... may be at greater risk for death on a ... on flights worldwide between January 2010 and June 2013 ... under the age of 2. , The study ... rare event of an in-flight pediatric fatality onboard commercial ...
(Date:8/1/2014)... gay, bisexual, and transgender individuals who want to conceive ... of their heterosexual and cisgendered peers, such as reduced ... physiological and legal challenges to become parents. A comprehensive ... options is presented in the article " LGBT Assisted ... LGBT Health , a peer-reviewed journal ...
(Date:8/1/2014)... PA (PRWEB) August 01, 2014 Hot off ... the destination spa category of the World’s Best Awards ... off a month-long celebration of National Relaxation Day (technically August ... a series of MAJOR experts to help guests celebrate relaxation ... important it is for health and wellness to carve out ...
(Date:8/1/2014)... many parents worry about their children choking on small objects ... Such was the case for 15-month-old Landon Jones who ... nuts. "At the time, Landon had a cold so ... his illness or choking," recalled his mother, Ula Jones. ... in his windpipe and had to be removed via surgery. ...
Breaking Medicine News(10 mins):Health News:J&J's Ethicon Unit Recalls its Power Morcellator Devices After Warnings by Federal Regulators and Concern About Risk of Spreading Occult Cancer, Parker Waichman Comments 2Health News:J&J's Ethicon Unit Recalls its Power Morcellator Devices After Warnings by Federal Regulators and Concern About Risk of Spreading Occult Cancer, Parker Waichman Comments 3Health News:J&J's Ethicon Unit Recalls its Power Morcellator Devices After Warnings by Federal Regulators and Concern About Risk of Spreading Occult Cancer, Parker Waichman Comments 4Health News:New research characterizes in-flight pediatric deaths 2Health News:Advances in assisted reproduction create more options and new legal issues for LGBT couples 2Health News:The Lodge at Woodloch Kicks Off National Relaxation Day with a Month Long Celebration 2Health News:The Lodge at Woodloch Kicks Off National Relaxation Day with a Month Long Celebration 3Health News:The Lodge at Woodloch Kicks Off National Relaxation Day with a Month Long Celebration 4Health News:Food Is a Common Choking Hazard for Kids, Doctor Says 2
... is offering a free kit to help families eat healthy ... year, a new chance to eat healthier every day: That,s ... Matters Month, sponsored by a number of leading medical and ... and vegetables in their family,s diets can get tips from ...
... SUNNYVALE, Calif., Sept. 7 Kyphon Inc.,(Nasdaq: ... 16, 2007, as the,date of the Special Meeting of ... owned subsidiary of Medtronic. The special meeting will ... headquarters located at 1221 Crossman Avenue, Sunnyvale,California 94089. Kyphon ...
... Appear Today in Major Indian Newspapers Includes, Chart Comparing ... ... DELHI, India, Sept. 6 As part of its,ongoing global campaign ... AIDS Healthcare Foundation (AHF),has published a print advertisement in the form ...
... MONICA, Calif., Sept. 6 The Foundation,for Taxpayer and ... debate has focused too much on what hospitals will ... what reform efforts will cost,consumers., Yesterday, FTCR sent ... of whether there will be any limits placed on ...
... BERKELEY HEIGHTS, N.J., Sept. 6 Authentidate,Holding ... of software and,web-based services that enable enterprises and ... transactions, today,announced that it plans to report financial ... June 30, 2007 on Thursday, September 13, 2007 ...
... Plexus Systems,Inc., providers of Plexus Online on-demand software ... named to the 2007 Inc. 5,000 list,of the ... ranked,at number 1581 with three-year sales growth of ... This is the first-ever Inc. 5,000 list of ...
Cached Medicine News:Health News:Get Your Fruits & Veggies: CDC 2Health News:Kyphon Announces Special Meeting Date to Vote on Proposed Medtronic Merger 2Health News:Kyphon Announces Special Meeting Date to Vote on Proposed Medtronic Merger 3Health News:'Cipla, Tell the Truth'; AIDS Healthcare Foundation Launches New Ad Campaign 2Health News:'Cipla, Tell the Truth'; AIDS Healthcare Foundation Launches New Ad Campaign 3Health News:'Cipla, Tell the Truth'; AIDS Healthcare Foundation Launches New Ad Campaign 4Health News:'Cipla, Tell the Truth'; AIDS Healthcare Foundation Launches New Ad Campaign 5Health News:'Cipla, Tell the Truth'; AIDS Healthcare Foundation Launches New Ad Campaign 6Health News:'Cipla, Tell the Truth'; AIDS Healthcare Foundation Launches New Ad Campaign 7Health News:Authentidate Holding Corp. to Report Fourth Quarter and Fiscal 2007 Year End Results on Thursday, September 13, 2007 2Health News:Authentidate Holding Corp. to Report Fourth Quarter and Fiscal 2007 Year End Results on Thursday, September 13, 2007 3Health News:Plexus Systems Ranks in Top Third of the 2007 Inc. 5,000 with Three-Year Sales Growth of 226% 2Health News:Plexus Systems Ranks in Top Third of the 2007 Inc. 5,000 with Three-Year Sales Growth of 226% 3
(Date:8/1/2014)... , Aug. 1, 2014 MGC ... technologies company, announced today that it has completed ... manufacturer of cardiorespiratory diagnostic products based in Sorinnes, ... has served the European cardiorespiratory diagnostics market since ... revenues of approximately €4.7 million ($6.3 million) and ...
(Date:8/1/2014)... 1, 2014 Dyadic International, Inc. ("Dyadic") (OTCQX: ... technologies are used to develop, manufacture and sell enzymes ... and industrial enzyme industries, announced today that it will ... June 30, 2014 after market close on Thursday, August ... day at 5:00 p.m. Eastern Time to discuss those ...
(Date:7/31/2014)... , July 31, 2014  Sorrento Therapeutics, Inc. (NASDAQ: ... Mr. Amar Singh , Chief Business Officer and Executive ... natural causes on July 30. "Sorrento is deeply ... and colleague. Our immediate thoughts go to Amar,s family and ... Chief Executive Officer. Mr. Singh joined Sorrento ...
Breaking Medicine Technology:MGC Diagnostics Corporation Completes Acquisition of MediSoft SA 2MGC Diagnostics Corporation Completes Acquisition of MediSoft SA 3MGC Diagnostics Corporation Completes Acquisition of MediSoft SA 4Dyadic International To Announce Second Quarter 2014 Financial Results And Host Conference Call On Thursday, August 14, 2014 2Dyadic International To Announce Second Quarter 2014 Financial Results And Host Conference Call On Thursday, August 14, 2014 3Sorrento Announces the Unexpected Death of its Chief Business Officer 2
... Research Group (MRG), the global authority on medical ... over $30 million in 2010. Revenues, however, remained ... prices and greater market penetration of refurbished scopes. ... manufacturers are being forced to promote creative options ...
... MORRISTOWN, N.J., Oct. 27 Watson Pharmaceuticals, Inc. (NYSE: ... Watson Laboratories, Inc., filed a new drug application under ... Act (FFDCA) with the U.S. Food and Drug Administration ... 20 and 40 mg tablets.  Watson,s rosuvastatin zinc tablets ...
Cached Medicine Technology:Despite Rising Procedure Volumes, the $30 Million European Arthroscope Market Experienced Nominal Growth in 2010 2Despite Rising Procedure Volumes, the $30 Million European Arthroscope Market Experienced Nominal Growth in 2010 3Watson Confirms Crestor® Patent Challenge 2
... Tip Laryngoscopes are the most ... The articulating tip aids during ... improved view of epiglottis. Available ... styles. We guarantee your complete ...
CCR Medical conventional laryngoscopes....
CCR Medical conventional laryngoscopes....
CCR Medical conventional laryngoscopes....
Medicine Products: