Navigation Links
MicroRNA that blocks bone destruction could offer new therapeutic target for osteoporosis
Date:6/25/2014

DALLAS June 25, 2014 UTSouthwestern cancer researchers have identified a promising molecule that blocks bone destruction and, therefore, could provide a potential therapeutic target for osteoporosis and bone metastases of cancer.

The molecule, miR-34a, belongs to a family of small molecules called microRNAs (miRNAs) that serve as brakes to help regulate how much of a protein is made, which in turn, determines how cells respond.

UTSouthwestern researchers found that mice with higher than normal levels of miR-34a had increased bone mass and reduced bone breakdown. This outcome is achieved because miR-34a blocks the development of bone-destroying cells called osteoclasts, which make the bone less dense and prone to fracture.

"This new finding may lead to the development of miR-34a mimics as a new and better treatment for osteoporosis and cancers that metastasize to the bone," said senior author Dr. Yihong Wan, Assistant Professor of Pharmacology and member of the UTSouthwestern Harold C. Simmons Cancer Center.

Her team found that injecting nanoparticles containing an artificial version, or mimic, of miR-34a into a mouse with post-menopausal osteoporosis decreased bone loss. "Interestingly, the mouse miR-34a is identical to that in humans, which means that our findings may apply to humans as well," said Dr. Wan, Virginia Murchison Linthicum Scholar in Medical Research at UTSouthwestern.

The study is published online in the journal Nature.

High levels of bone destruction and reduced bone density caused by excessive osteoclasts are characteristic of osteoporosis, a common bone disease in which bones become fragile and susceptible to fracture.
'/>"/>

Contact: Russell Rian
russell.rian@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Why inflammation leads to a leaky blood-brain barrier: MicroRNA-155
2. Wound-healing role for microRNAs in colon offer new insight to inflammatory bowel diseases
3. MicroRNA that could be used to suppress prostate cancer progression found
4. MicroRNA could be key target for bowel cancer treatment
5. Fruit fly microRNA research at Rutgers-Camden offers clues to aging process
6. Viral microRNAs responsible for causing AIDS-related cancer, new USC study shows
7. Wayne State to study role of microRNAs in prostate cancer racial disparities
8. MicroRNA-31 might predict lung-cancer spread
9. Versatile microRNAs choke off cancer blood supply, suppress metastasis
10. Loss of MicroRNA decoy might contribute to development of soft-tissue sarcoma
11. New papers identify a microRNA that drives both cancer onset and metastasis
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
MicroRNA that blocks bone destruction could offer new therapeutic target for osteoporosis
(Date:6/30/2015)... , ... June 30, 2015 , ... ... launching MEDFLOW 2.0 EHR, a SaaS electronic health records system from the company ... evolution in software, Medflow 2.0 delivers an intuitive state-of-the-art solution combining modern cloud ...
(Date:6/30/2015)... ... ... “It is never too early to be proactive about sun protection,” states ... the word out to children because sun damage is cumulative and the result of ... our new video which we feel is a fun way to educate children about ...
(Date:6/29/2015)... ... June 30, 2015 , ... The United States Equestrian ... (KORT) as it becomes the Official Physical and Occupational Therapists of the U.S. Eventing ... Kentucky Three-Day Event presented by Land Rover. , “The USEF is pleased to ...
(Date:6/29/2015)... ... 2015 , ... An upcoming documentary for public television by the Sports ... a fresh perspective on conflict in sports with guest speakers including sports culture and ... from around the sports industry that will discuss challenges in competitive sports and how ...
(Date:6/29/2015)... ... June 29, 2015 , ... Healthpointe, one of Southern California’s ... newest FAA-certified medical examiner in the city of Colton . , The ... to obtain their physical aviation certificates. Pilots hoping to navigate airplanes, helicopters, gyroplanes, ...
Breaking Medicine News(10 mins):Health News:Medflow Launches MEDFLOW 2.0 EHR – The Cloud-Based Ophthalmology EHR 2Health News:SunGrubbies.com, a Leading Online Retailer of Sun Protection Products, Joins Effort to Promote Sun Safety 2Health News:SunGrubbies.com, a Leading Online Retailer of Sun Protection Products, Joins Effort to Promote Sun Safety 3Health News:KORT Physical Therapy Announces Partnership with The United States Equestrian Federation 2Health News:Dr. Marc Williams Joins SCI and In America Sports Documentary 2Health News:Dr. Marc Williams Joins SCI and In America Sports Documentary 3Health News:Healthpointe Now Offering FAA Physical Exams in San Bernardino County 2
... Next week, the House,Committee on Foreign Relations will ... Relief (PEPFAR). Family Research Council (FRC),President Tony Perkins released ... by Rep. Tom Lantos (D-CA):, "The Lantos bill ... giveaway that will be tilted toward those who perform ...
... Medical Records,System, HARRISBURG, Pa., Feb. 7 ... of medical care for Pennsylvania,s,46,000 inmates, the Department ... Inc., have agreed to a five-year extension of ... a matter of importance to the,department," said Corrections ...
... Diabetes Impact,the Profession, BETHESDA, Md., Feb. 7 ... economy, entering the field of,podiatric medicine -- which currently ... the right direction. A recent workforce study indicates,that the ... triple,their graduates between now and 2014 in order to ...
... to Launch 2008 Income Tax Check-Off,Campaign, HERSHEY, ... participate in the state,s Income Tax Check-Off,for Breast ... of dollars in grants that will be awarded ... at 9:30 a.m., the,Pennsylvania Breast Cancer Coalition will ...
... Physical Examination Center in Beijing Airport to Use ... for Travelers During Olympic Games, CALGARY, Feb. ... IDL), the global leader in digital radiography for ... awarded a contract for its,1600 X-Series digital radiography ...
... One might call it a tale of two melanocytes. ... shut down growth and become a relatively benign mole, ... deadly melanoma", In trying to tease out the answer ... researchers have uncovered a protein that stops the growth ...
Cached Medicine News:Health News:Pennsylvania Corrections Department to Extend Medical Contract, Save $55 Million 2Health News:Looking for a Career? A New Study Shows Demand for Doctors of Podiatric Medicine to Surge Over the Next Six Years 2Health News:The Pennsylvania Breast Cancer Coalition Announces 2008 Breast Cancer Income Tax Check-Off Grant Recipients 2Health News:IDC Awarded Digital Radiography Contract With Beijing Capital Airport 2Health News:IDC Awarded Digital Radiography Contract With Beijing Capital Airport 3Health News:Genome-wide survey nets key melanoma gene 2Health News:Genome-wide survey nets key melanoma gene 3Health News:Genome-wide survey nets key melanoma gene 4
(Date:6/29/2015)... June 29, 2015 ... (Troitsk) und Strand Life Sciences, weltweiter Marktführer ... Medizin, haben eine Kooperationsvereinbarung unterzeichnet. Laut Vereinbarung ... entwickeln, basierend auf NGS (Next-Generation Sequencing), für ... Formen von Epilepsie und primären Immundefizenz (PI)-Erkrankungen. ...
(Date:6/29/2015)... N.Y. and EWING, N.J. ...  (Nasdaq: CPXX ) today announced that The Leukemia ... a portion of the final payment linked to the ... lead product candidate, for the treatment of patients with ... moved forward payment of $400,000 originally attached to the ...
(Date:6/29/2015)... MOSCOW , June 29, 2015 /PRNewswire/ ... nanocenter TECHNOSPARK (Troitsk), and Strand Life Sciences, the ... personalized medicine, have signed a cooperation memorandum. According ... develop affordable tests based on next-generation sequencing (NGS) ... hereditary forms of epilepsy and primary immunodeficiency disorders ...
Breaking Medicine Technology:Das Genomic Center of Nanocenters 'Technospark' und 'Dubna', Russland und Strand Life Sciences, Indien werden gemeinsam Tests zur Diagnose von Erbkrankheiten entwickeln 2Das Genomic Center of Nanocenters 'Technospark' und 'Dubna', Russland und Strand Life Sciences, Indien werden gemeinsam Tests zur Diagnose von Erbkrankheiten entwickeln 3The Leukemia & Lymphoma Society Accelerates Milestone Payment Associated with the Phase 3 Study of CPX-351 in High Risk (Secondary) AML 2The Leukemia & Lymphoma Society Accelerates Milestone Payment Associated with the Phase 3 Study of CPX-351 in High Risk (Secondary) AML 3The Leukemia & Lymphoma Society Accelerates Milestone Payment Associated with the Phase 3 Study of CPX-351 in High Risk (Secondary) AML 4The Leukemia & Lymphoma Society Accelerates Milestone Payment Associated with the Phase 3 Study of CPX-351 in High Risk (Secondary) AML 5The Leukemia & Lymphoma Society Accelerates Milestone Payment Associated with the Phase 3 Study of CPX-351 in High Risk (Secondary) AML 6The Genomic Center of Nanocenters 'Technospark' and 'Dubna', Russia and Strand Life Sciences, India to Co-develop Tests for Diagnosis of Inherited Diseases 2The Genomic Center of Nanocenters 'Technospark' and 'Dubna', Russia and Strand Life Sciences, India to Co-develop Tests for Diagnosis of Inherited Diseases 3
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
Medicine Products: