Navigation Links
MicroRNA molecule may serve as biomarker, target for brain metastases in breast cancer patients
Date:2/5/2013

PHILADELPHIA Researchers have identified two molecules that could potentially serve as biomarkers in predicting brain metastases in patients with breast cancer, according to data published in Cancer Research, a publication of the American Association for Cancer Research.

Currently, most deaths from breast cancer are a result of metastatic disease. New research shows that cancer stem-like cells commonly defined as cells within a tumor with the capacity to initiate a new tumor, proliferate rapidly, differentiate and cause chemotherapy resistance may play a role in breast cancer metastasis.

"Recent research has shown that microRNAs are involved in tumor initiation and progression, and we hypothesized that they also may play a role in metastasis, particularly in relation to cancer stem-like cells," said Kounosuke Watabe, Ph.D., associate director for basic science at the University of Mississippi Medical Center in Jackson, Miss.

Watabe and colleagues performed microRNA profile analysis on RNA extracted from cancer stem-like cells isolated from a human breast cancer cell line and two highly metastatic variants of this cell line.

"We found that miR-7 is a metastasis suppressor in cancer stem-like cells," Watabe said. "When we increased expression of miR-7 in cancer stem-like cells from metastatic human breast cancer cell lines, it suppressed their metastatic properties."

Next, the researchers examined the molecular pathway downstream of miR-7 to find its targets and discovered that miR-7 suppressed expression of KLF4.

"High expression of KLF4 was inversely associated with brain metastasis-free survival but was not associated with bone metastasis," Watabe said. "This was confirmed in an animal model when we found that expression of miR-7 significantly suppressed the ability of cancer stem-like cells to metastasize to the brain but not the bone."

Finally, the researchers tested tumor samples fr
'/>"/>

Contact: Jeremy Moore
jeremy.moore@aacr.org
215-446-7109
American Association for Cancer Research
Source:Eurekalert

0

GOOD

Page: 1 2

Related medicine news :

1. A microRNA prognostic marker identified in acute leukemia
2. Pint-size microRNAs show promise against weighty problem, researchers say
3. MicroRNAs can convert normal cells into cancer promoters
4. Hepatitis B virus promotes oncogenesis through microRNA modulation
5. Molecule movements that make us think
6. Prions in the brain eliminated by homing molecules
7. Researchers identify a life-and-death molecule on chronic leukemia cells
8. Inhibitors of shuttle molecule show promise in acute leukemia
9. Mayo Clinic: Molecule thought cancer foe actually helps thyroid tumors grow
10. Cleveland Clinic researchers discover molecule that may prevent atherosclerosis
11. Molecule found that inhibits recovery from stroke
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/18/2013)... 18, 2013 As metal-on-metal hip ... the country, Bernstein Liebhard LLP notes that a new ... suffer tissue damage before they experience any pain from ... Science Daily will appear in the Journal of Bone ... MRI screens of their hips. The researchers found ...
(Date:5/18/2013)... 18, 2013 Although obesity is associated ... association between obesity and esophageal adenocarcinoma, a type of ... tumors. As reported on Cancer.gov, last reviewed ... twice as likely as those of normal and healthy ... between obesity and esophageal cancer is not well understood, ...
(Date:5/18/2013)... The “Sleep Apnea Diagnostic & Therapeutic Devices Market [Polysomnographs, ... Oral Appliances, Nasal EPAP, Neurostimulation] Global End-user Analysis, Competitive ... major market drivers, restraints, and opportunities in North America, ... , 147 market data tables ... 318 pagesand in-depth TOC of “Sleep Apnea ...
(Date:5/18/2013)... (PRWEB) May 18, 2013 Adolescents, especially ... known as “Spice” or “K2” are landing in emergency ... to curb this drug epidemic with a new ... marijuana. , According to research from the National Institute ... popular illegal drug among American teenagers. In 2012, 11 ...
(Date:5/18/2013)... Mexico, DF (PRWEB) May 18, 2013 ... by leading ayurvedic education institution in the West. Program ... Learning education. , Ayurveda is a healing modality practiced ... Ayurvedica ), it is considered that health begins when ... a profound understanding of their individual needs. Ayurveda aims ...
Breaking Medicine News(10 mins):Health News:Metal-on-Metal Hip Implants: Bernstein Liebhard LLP Comments on New Study Finding that Tissue Damage Precedes Pain in Metal-on-Metal Hip Replacement Patients 2Health News:Metal-on-Metal Hip Implants: Bernstein Liebhard LLP Comments on New Study Finding that Tissue Damage Precedes Pain in Metal-on-Metal Hip Replacement Patients 3Health News:Metal-on-Metal Hip Implants: Bernstein Liebhard LLP Comments on New Study Finding that Tissue Damage Precedes Pain in Metal-on-Metal Hip Replacement Patients 4Health News:hCGtreatments / Diet Doc Hcg Diets & Weight Loss Plans Announces New Prescription Hcg Diet Plans Designed to Trim Inches and Thus Reduce the Risk of Esophageal Cancer 2Health News:hCGtreatments / Diet Doc Hcg Diets & Weight Loss Plans Announces New Prescription Hcg Diet Plans Designed to Trim Inches and Thus Reduce the Risk of Esophageal Cancer 3Health News:Sleep Apnea Devices Market to reach $19.72 Billion by 2017 - New Report by MarketandMarkets 2Health News:Sleep Apnea Devices Market to reach $19.72 Billion by 2017 - New Report by MarketandMarkets 3Health News:Spice Addiction Treatment and Synthetic Marijuana Drug Rehab Announced by Recovery Associates 2Health News:Ayurveda Training in Mexico Offered by Escuela de Ayurveda de California, a Leading Institution in the West 2
... Center scientists are presenting research today on a more ... been unresponsive to current// drug therapies. ... Infergen, a highly potent Interferon, is nearly twice as ... are sharing their findings at the annual American Association ...
... confusing. And most of us can recall having difficulty ... you have stopped taking a// prescription too soon because ... prevents you from accurately reading the label on the ... of good health care. ,Communication problems with ...
... pink race gear on e Bay in favor of Susan ... Awareness month and pink is// the symbolic color of Breast ... Racing to create exclusive warriors in pink livery with exclusive ... the eBay auction. ,Parts of the Warrior in ...
... that result in almost 34,000 deaths a year in hospitals ... Healthcare Commission which inspects the NHS.// The independent health watchdog ... priority for the NHS. ,Although the exact ... known completely previous studies have estimated it is up to ...
... Turmeric the must have spice in every Indian home now ... its potential uses to fight// many tubborn inflammations and degenerative ... the ancient scripts of Ayurveda. ,According to a ... Medicine by Janet L. Funk, MD, working with Barbara N. ...
... ridden NHS hospital's radiotherapy department to dogs and cats ailing ... , ,To effectively manage the ?24m debt at Ipswich ... a pets’ clinic could be instituted on Saturdays to put ... with the huge debt. According to the calculations made ...
Cached Medicine News:Health News:Making Headway Against Hepatitis C 2Health News:Low Health Literacy Interferes with Good Health Care 2Health News:Patient Safety Not Addressed by NHS 2Health News:Patient Safety Not Addressed by NHS 3Health News:Pet Peeves: Conservatives Howl at Proposal to Share NHS Hosp by Pets and People 2
(Date:5/17/2013)... 2013 The power of plants to cure ... which mankind depends on the plant kingdom, is the ... Wild Medicine: Healing Plants Around the ... from May 18 through September 8, 2013. ... exhibition,s many attractions include a re-creation of the Western ...
(Date:5/17/2013)... -- Orexigen® Therapeutics, Inc. (Nasdaq: OREX ) today announced ... Global Healthcare Conference in New York . ... at 11 a.m. Eastern Time. To listen to the live ... Investor Relations section of the Company,s Web site at ... after the event. About Orexigen® Therapeutics Orexigen ...
(Date:5/17/2013)... 17, 2013  Sony Biotechnology Inc. ("Sony") today announced ... (SP6800).  Sony will be exhibiting and taking orders for ... at the San Diego Convention ... from May 20 - 22.  The ... commercial audio-visual technologies into new and novel functionalities for ...
Breaking Medicine Technology:Wild Medicine On View at The New York Botanical Garden Through Sept. 8 2Sony Biotechnology Inc.'s New Technology for Science Provides Researchers Results in Color 2
... /PRNewswire-Asia/ -- Recently, Wang Qiao, the eight-year program student ... tutored under Yan Lynan, went to San Francisco to ... meeting with the director of his department, Mr. Li ... The theme of the meeting is "The Pros ...
...  Marken announced today that it has opened its first ... service operations and offer local service to its customers ... operates in the country through its partners, managing thousands ... country.  This new office has been created recognizing that ...
Cached Medicine Technology:Student of Liver And Vascular Surgery of West China Hospital of Sichuan University Addresses The 18th ILTS Annual Meeting in the United States 2Marken Opens Branch Office In Seoul, South Korea 2
... Perimeter utilizes Welch Allyn Frequency Doubling ... in visual field testing by combining ... characterize glaucoma and basic glaucoma management ... the Matrix doubles as an in-office ...
... IMAGE1 is the first completely digital ... first in the field of endoscopic camera ... for the first time, facilitates the fully ... in quality using an A/D converter, as ...
... It has long been ... evacuation to be used during ... the healthcare industry contend that ... procedures is as harmful as ...
Erbium Laser with Sapphire Erbium Handpiece for Dermatological and Cosmetic Surgery...
Medicine Products: