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MicroRNA molecule increases number of blood stem cells, may help improve cancer treatment
Date:8/4/2010

California Institute of Technology, also released online, found that elevated levels of a related molecule called miRNA-125b in HSCs could lead to an aggressive form of leukemia in mice. "These molecules modify cellular numbers in ways that can be both beneficial and detrimental, so it will be important to understand the differences," Scadden explains.

"We're now looking at ways to expand the stem cell population to briefly turn on the anti-cell-death protection to overcome limited levels of stem cells that can restrict the use of stem cell transplantation for patients with blood system failure and blood-cell cancers. Accomplishing that could make life-saving stem cell transplants available to more patients," he adds. Scadden is the Gerald and Darlene Jordan Professor of Medicine at Harvard Medical School and co-director of the Harvard Stem Cell Institute.


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Contact: Sue McGreevey
smcgreevey@partners.org
617-724-2764
Massachusetts General Hospital
Source:Eurekalert

Page: 1 2

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