Navigation Links
MicroRNA molecule increases number of blood stem cells, may help improve cancer treatment
Date:8/4/2010

Investigators have identified a new mechanism that controls the number of hematopoietic stem cells cells that give rise to all blood and immune system cells. In a report in the online Early Edition of Proceedings of the National Academy of Sciences, researchers from Massachusetts General Hospital (MGH) and the Harvard Stem Cell Institute identify a tiny RNA molecule that increases the number of these blood stem cells, an advance that may improve treatment of blood system cancers.

"This novel molecule raises blood stem cell numbers by suppressing the normal cell-death process," explains David Scadden, MD, director of the MGH Center for Regenerative Medicine and senior author of the report. "We've known that these non-coding RNAs can define what an immature cell will become, but none has previously been identified that can tell a blood system stem cell whether to live or die."

MicroRNAs short strands of RNA not involved in the production of proteins bind to and silence the expression of their target genes and play important roles in cellular development and differentiation, including the process by which hematopoietic stem cells (HSCs) mature into red or white blood cells. Since the process that controls the size of the HSC population is unknown, the researchers investigated whether microRNAs were involved. They found that loss of the enzyme Dicer, known to be essential to the generation of microRNAs, caused the death of HSCs, supporting the involvement of microRNAs in maintaining HSC levels.

Futher investigation identified a cluster of microRNAs present at enhanced levels in HSCs and showed that one of them, miRNA-125a, increased numbers of HSCs by protecting them from the cell-death process that normally limits cellular populations. The protective effects of miRNA-125a were only seen at the stem-cell level and may involve suppression of the cell-death protein Bak1.

A related PNAS study from researchers at California Institute of Technology, also released online, found that elevated levels of a related molecule called miRNA-125b in HSCs could lead to an aggressive form of leukemia in mice. "These molecules modify cellular numbers in ways that can be both beneficial and detrimental, so it will be important to understand the differences," Scadden explains.

"We're now looking at ways to expand the stem cell population to briefly turn on the anti-cell-death protection to overcome limited levels of stem cells that can restrict the use of stem cell transplantation for patients with blood system failure and blood-cell cancers. Accomplishing that could make life-saving stem cell transplants available to more patients," he adds. Scadden is the Gerald and Darlene Jordan Professor of Medicine at Harvard Medical School and co-director of the Harvard Stem Cell Institute.


'/>"/>

Contact: Sue McGreevey
smcgreevey@partners.org
617-724-2764
Massachusetts General Hospital
Source:Eurekalert

Related medicine news :

1. Scientists identify microRNA as possible cause of chemotherapy resistance
2. Study links microRNA to shut-down of DNA-repair genes
3. Cancer cells show rewired, fragmented microRNA networks
4. IU research team discovers TB disease mechanism and molecule to block it
5. Tiny molecules may tell big story about cardiovascular disease risk
6. New Cancer-Fighting Strategy Focuses On Signaling Molecules
7. Small molecule with high impact
8. Sigma-Aldrich Reaches Agreement to Sell Pfizers Bioactive Small Molecule Compounds
9. Inflammation Molecule May Determine Fat Levels
10. Exploring the Davids and Goliaths of therapeutic molecules
11. ACS Webinar focuses on drug discovery process for small molecule therapeutics
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/28/2017)... ORANGE, Calif. (PRWEB) , ... March 28, 2017 ... ... of its leading physicians, Paul Yost, will begin serving as new board chair ... earlier this month. Yost will serve the remainder of soon-to-be former chair Mark ...
(Date:3/28/2017)... ... March 28, 2017 , ... In its ongoing effort ... has recently developed and published an informational resource that addresses frequently asked questions. ... common inquiries the site’s team of third party administrator (TPA) contributors regularly receives ...
(Date:3/28/2017)... Santa Monica, CA (PRWEB) , ... March 28, ... ... expert, Dr. Carson Liu of SkyLex Advanced Surgical, Inc. is thrilled to offer ... newest gastric balloon procedure, and this procedure adds to SkyLex Advanced Surgical’s ...
(Date:3/28/2017)... ... ... common and unwelcomed occurrence in people of all ages, genders and ethnicities. Dermatologist Dr. Sonoa ... dealing with excess skin oil. “Oily skin is a challenge to many of my patients. ... oily shine while keeping the skin fresh and clean,” says Dr. Au. , What causes ...
(Date:3/27/2017)... ... March 27, 2017 , ... New patients who have ... sleep apnea treatment, with or without a referral. Sleep apnea is often left untreated ... daytime sleepiness, morning headaches and chronic snoring. , Dr. Braasch seeks to raise ...
Breaking Medicine News(10 mins):
(Date:3/27/2017)... AVIV, Israel , March 27, 2017 ... on oncology and immunology, announced today that AGI-134, an immunotherapy ... announced acquisition of Agalimmune Ltd., will be featured at the ... in Washington, DC to be ... ...
(Date:3/27/2017)... March 27, 2017   Pulmatrix, Inc . (NASDAQ: PULM), ... address serious pulmonary diseases, today announced that it has added ... fibrosis and asthma to its Scientific Advisory Board . ... Richard B. Moss , MD, former chief of the ... Cystic Fibrosis Center at Stanford University, and ...
(Date:3/27/2017)... , March 27, 2017  BERG, a ... data-driven, biological research approach, today announced that ... the discovery of new data using a ... brown fat metabolism. Joslin Diabetes Center led ... Biology® platform for analysis of samples.  The ...
Breaking Medicine Technology: