Navigation Links
MicroRNA molecule increases number of blood stem cells, may help improve cancer treatment
Date:8/4/2010

Investigators have identified a new mechanism that controls the number of hematopoietic stem cells cells that give rise to all blood and immune system cells. In a report in the online Early Edition of Proceedings of the National Academy of Sciences, researchers from Massachusetts General Hospital (MGH) and the Harvard Stem Cell Institute identify a tiny RNA molecule that increases the number of these blood stem cells, an advance that may improve treatment of blood system cancers.

"This novel molecule raises blood stem cell numbers by suppressing the normal cell-death process," explains David Scadden, MD, director of the MGH Center for Regenerative Medicine and senior author of the report. "We've known that these non-coding RNAs can define what an immature cell will become, but none has previously been identified that can tell a blood system stem cell whether to live or die."

MicroRNAs short strands of RNA not involved in the production of proteins bind to and silence the expression of their target genes and play important roles in cellular development and differentiation, including the process by which hematopoietic stem cells (HSCs) mature into red or white blood cells. Since the process that controls the size of the HSC population is unknown, the researchers investigated whether microRNAs were involved. They found that loss of the enzyme Dicer, known to be essential to the generation of microRNAs, caused the death of HSCs, supporting the involvement of microRNAs in maintaining HSC levels.

Futher investigation identified a cluster of microRNAs present at enhanced levels in HSCs and showed that one of them, miRNA-125a, increased numbers of HSCs by protecting them from the cell-death process that normally limits cellular populations. The protective effects of miRNA-125a were only seen at the stem-cell level and may involve suppression of the cell-death protein Bak1.

A related PNAS study from researchers at California Institute of Technology, also released online, found that elevated levels of a related molecule called miRNA-125b in HSCs could lead to an aggressive form of leukemia in mice. "These molecules modify cellular numbers in ways that can be both beneficial and detrimental, so it will be important to understand the differences," Scadden explains.

"We're now looking at ways to expand the stem cell population to briefly turn on the anti-cell-death protection to overcome limited levels of stem cells that can restrict the use of stem cell transplantation for patients with blood system failure and blood-cell cancers. Accomplishing that could make life-saving stem cell transplants available to more patients," he adds. Scadden is the Gerald and Darlene Jordan Professor of Medicine at Harvard Medical School and co-director of the Harvard Stem Cell Institute.


'/>"/>

Contact: Sue McGreevey
smcgreevey@partners.org
617-724-2764
Massachusetts General Hospital
Source:Eurekalert

Related medicine news :

1. Scientists identify microRNA as possible cause of chemotherapy resistance
2. Study links microRNA to shut-down of DNA-repair genes
3. Cancer cells show rewired, fragmented microRNA networks
4. IU research team discovers TB disease mechanism and molecule to block it
5. Tiny molecules may tell big story about cardiovascular disease risk
6. New Cancer-Fighting Strategy Focuses On Signaling Molecules
7. Small molecule with high impact
8. Sigma-Aldrich Reaches Agreement to Sell Pfizers Bioactive Small Molecule Compounds
9. Inflammation Molecule May Determine Fat Levels
10. Exploring the Davids and Goliaths of therapeutic molecules
11. ACS Webinar focuses on drug discovery process for small molecule therapeutics
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... ... ... Austin residents seeking Mohs surgery services, can now turn to Dr. Jessica ... Peckham for medical and surgical dermatology. , Dr. Dorsey brings specialization to include Mohs ... Mohs Micrographic Surgery completed by Dr. Dorsey was under the direction of Glenn Goldstein, ...
(Date:6/25/2016)... Oklahoma (PRWEB) , ... June 25, 2016 , ... ... both athletes and non-athletes recover from injury. Recently, he has implemented orthobiologic procedures ... Oklahoma City area —Johnson is one of the first doctors to perform the ...
(Date:6/24/2016)... ... June 24, 2016 , ... June 19, 2016 is World Sickle ... chronic pain and the benefits of holistic treatments, Serenity Recovery Center of ... Sickle Cell Disease. , Sickle Cell Disease (SCD) is a disorder of the red ...
(Date:6/24/2016)... ... June 24, 2016 , ... Comfort Keepers® of San Diego, CA ... the Road To Recovery® program to drive cancer patients to and from their cancer ... ensure the highest quality of life and ongoing independence. Getting to and from ...
(Date:6/24/2016)... ... June 24, 2016 , ... Puradigm® ... Group (TGIG), has initiated cultivation and processing operations at its production facility, and ... Nevada. , Puradigm is the manufacturer of a complete system of proactive air ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... -- Jazz Pharmaceuticals plc (Nasdaq: JAZZ ) ... Improvements Act of 1976, as amended ("HSR"), with respect ... Nasdaq: CPXX ) expired effective June 24, ... As previously announced on May 31, 2016, Jazz Pharmaceuticals ... which Jazz Pharmaceuticals has commenced a tender offer for ...
(Date:6/24/2016)... SAN FRANCISCO, Calif. , June 24, 2016 ... GBT ), a biopharmaceutical company developing novel therapeutics ... significant unmet needs, today announced the closing of ... shares of common stock, at the public offering ... shares in the offering were offered by GBT. ...
(Date:6/24/2016)... June 24, 2016 Dehaier Medical Systems Ltd. ... which develops, markets and sells medical devices and wearable ... signed a strategic cooperation agreement with Hongyuan Supply Chain ... Chain") on June 20, 2016, to develop Dehaier,s new ... cooperation agreement, Dehaier will leverage Hongyuan Supply Chain,s sales ...
Breaking Medicine Technology: