Navigation Links
MicroRNA controls expression of oncogenes
Date:6/9/2008

A new study demonstrates that microRNAs can modulate the expression of well known tumor-specific oncogenic translocation proteins and may play a significant role in some human cancers. The research, published by Cell Press in the June issue of the journal Cancer Cell, is likely to lead to new strategies for treating some specific lymphomas and leukemias.

MicroRNAs (miRNAs) are small noncoding pieces of RNA that can modulate the expression of specific target genes. Recent studies have suggested that increases or decreases in miRNA expression may be linked with regulation of oncogenes or tumor suppressors and are therefore likely to play an important role in human cancers.

Dr. Marcos Malumbres from the Spanish National Cancer Research Center (CNIO) in Madrid, Spain and colleagues identified a miRNA-rich chromosomal region in mice that is frequently lost in T cell malignancies. This particular region encodes about 12% of all genomic miRNAs. The researchers used miRNA expression profiling to reveal that one particular miRNA, miR-203, is silenced by both genetic and epigenetic mechanisms in several mouse and human blood cell malignancies, including chronic myelogenous leukemias and some acute lymphoblastic leukemias.

The researchers went on to show that transcriptional silencing of miR-203 lead to upregulation of the oncogene ABL1 and the BCR-ABL1 oncogenic fusion protein in various mouse and human hematopoietic malignancies. Further, restoration of miR-203 resulted in a subsequent reduction of ABL1 and BCR-ABL1 and in decreased proliferation of tumor cells.

"Our results suggest that miR-203 functions as a tumor suppressor and re-expression of this microRNA might have therapeutic benefits in specific hematopoietic malignancies, including some acute or chronic leukemias," concludes Dr. Malumbres. "This may be particularly beneficial for patients who are resistant to small molecule kinase inhibitors like Gleevec as resistant isoforms of ABL and BCR-ABL should contain the target site for miR-203 and are likely to respond to restored miR-203 function."


'/>"/>

Contact: Cathleen Genova
cgenova@cell.com
617-397-2802
Cell Press
Source:Eurekalert

Related medicine news :

1. MicroRNAs appear essential for retinal health
2. MicroRNAs, EMT and cancer progression
3. Replacing absent microRNAs could make tumors less invasive, more treatable
4. Single microRNA fine-tunes innate immune response
5. MicroRNAs May Predict Colon Cancer Prognosis
6. 2 microRNAs promote spread of tumor cells
7. Rosetta Genomics Strengthens Senior Management in Preparation for its First Commercial Launch of microRNA-Based Diagnostic Products in 2008
8. Sigma-Aldrich Announces mirPremier(TM) microRNA Isolation Kit for miRNA Purification
9. MicroRNAs may be key to HIVs ability to hide, evade drugs, Jefferson scientists find
10. Monkey Controls Robotic Arm With Brain
11. Stem Cell Marker Controls Pair of Key Cancer Pathways
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/26/2017)... ... February 26, 2017 , ... ... technology standard in staffing, scheduling, and reporting for healthcare organizations. This comprehensive ... throughout the entire staffing process. StaffBridge technology improves staffing efficiency, maximizes resource ...
(Date:2/25/2017)... Viejo, CA (PRWEB) , ... February 25, 2017 , ... ... with ProSharpen Color tools from Pixel Film Studios. With ProSharpen Color users have total ... sliders to easily refine their color range. With color spectrum tools users can visually ...
(Date:2/24/2017)... Princeton, NJ (PRWEB) , ... February 24, 2017 ... ... organization that provides business development, education, networking and recognition opportunities as well as ... at Bell Works in Holmdel, NJ on February 23. The Council's Innovation ...
(Date:2/24/2017)... ... February 24, 2017 , ... In the Health Care IT campaign, ... priority because it’s not if you will be attacked, but when.” However, he and ... to digital health care. , Improvements in auditing and monitoring have taken security in ...
(Date:2/24/2017)... , ... February 24, 2017 , ... With ProGlass Prism ... Pro X . Users have total control over position, rotation, distortion, edge softness, edge ... within Final Cut Pro X. , With ProGlass Prism users are given the tools ...
Breaking Medicine News(10 mins):
(Date:2/23/2017)... LG Innotek hat heute die weltweit erste ... das 1,5-fache des 45-mW-Moduls der Konkurrenz. UV-C ... und 280 nm und eignet sich damit für Sterilisationsaufgaben. Es ... zerstört. Das Produkt von LG Innotek erzeugt UV-Strahlung im ... ...
(Date:2/23/2017)... Februar 2017 Im Rahmen seiner Schlüsselwachstumsstrategie ... in der südwestlichen chinesischen Provinz Guizhou, 2017 mit dem Angebot ... aktiv an der Entwicklung einer eingebetteten Hightech-Schlüsselindustrie. Foto ... Reading ... ...
(Date:2/23/2017)... 23, 2017 Obese people are ... for varicose veins in their body. The rising number ... the adoption of endovenous laser therapy for treatment of ... laser therapy market, published by Future Market Insights, ... and consequences of obesity have collectively factored the growth ...
Breaking Medicine Technology: