Navigation Links
MicroRNA-31 might predict lung-cancer spread
Date:9/24/2013

COLUMBUS, Ohio Determining whether a patient's lung cancer has spread to nearby lymph nodes is critical for identifying the most effective therapy, but it usually requires surgery. A new study suggests, however, that measuring levels of a particular molecule in a sample of tumor tissue might accurately answer the question.

Researchers at The Ohio State University Comprehensive Cancer Center Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC James) have discovered that levels of microRNA-31 (miR-31) predict the spread of the most common form of lung cancer to nearby lymph nodes.

They found that high levels of miR-31 in primary tumor cells predicted lymph node metastasis and poor survival in patients with non-small cell lung cancer (NSCLC). Low expression levels were associated with the absence of metastases and excellent survival.

The findings are published in the journal Clinical Cancer Research.

"Our findings suggest that microRNA expression in the primary lung tumor can estimate whether the tumor has spread to the lymph nodes and can help direct patients to the most appropriate treatment," says principal investigator Tim Lautenschlaeger, MD, a researcher in Radiation Oncology and the OSUCCC James Experimental Therapeutics Program.

"Many patients undergo radiation therapy for NSCLC, and particularly those with early stage disease do not routinely undergo surgical staging," he explains. "Staging with positron emission tomography-computed tomography is very useful but not perfect. MiR-31 and other microRNAs can potentially improve our ability to correctly stage these patients.

"Additionally, if we can better estimate invasiveness of each patient's tumor, we could individualize treatment to include the invasive microscopic disease while sparing as much normal tissue as possible."

An estimated 228,190 cases of lung cancer are expected to occur in the United States in 2013, along with 159,500 deaths from the disease. NSCLC accounts for about 80 percent of all lung-cancer patients. Adenocarcinoma is the most common subtype, representing about 40 percent of all lung cancer cases.

MicroRNAs are a class of short, non-coding RNAs that regulate the translation or degradation of messenger RNA and therefore the proteins that cells make. Certain microRNAs are frequently dysregulated in cancer and are associated with tumor initiation and progression.

For this study, Lautenschlaeger and his colleagues examined samples of primary lung adenocarcinoma tissue from 43 patients. They analyzed 10 of these using genome-wide microRNA-sequencing; four of these cases had lymph node metastases and six were free of metastases.

Key technical findings included:

  • MiR-31 expression was four times higher in patients with lymph node metastases compared with those without them;
  • miR-31 increases cell migration, invasion and proliferation;
  • High miR-31 expression predicted poor survival, while low expression was associated with excellent survival.

"Overall, our findings provide a rationale to further evaluate microRNAs as biomarkers to determine which early-stage NSCLC patients treated with radiation therapy might benefit from additional cancer therapy," Lautenschlaeger says.


'/>"/>

Contact: Darrell E. Ward
Darrell.Ward@osumc.edu
614-293-3737
Ohio State University Wexner Medical Center
Source:Eurekalert

Related medicine news :

1. New Stool Test Might Aid in Early Detection of Colon Cancer
2. Depo-Provera Birth Control Might Raise Breast Cancer Risk
3. Brain Falters Near End of Life, but Games, Puzzles Might Slow Decline
4. Infection Might Raise Blood Clot Risk for Older Adults: Study
5. Anxiety Might Help People Sniff Out Threats
6. Lung Cancer Screening Might Pay Off, Analysis Shows
7. Mobile Stroke Units Might Trim Time to Treatment
8. Common Plastics Chemical Might Boost Diabetes Risk
9. Media Multitasking Might Have Mental Upside
10. Brain Surgery Might Ease Tough-to-Treat OCD
11. More Smog Might Mean More Hospitalizations
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/20/2017)... (PRWEB) , ... July 20, 2017 , ... The Dermatology ... staff. Dr. Dunbar received his BS in Biology from LSU, graduating summa cum laude. ... School Class President. After his residency in St. Louis, Dr. Dunbar moved to New ...
(Date:7/20/2017)... ... July 20, 2017 , ... There’s a lot of ... and bulging discs are the same thing. But it’s crucial to understand both the ... proper treatment, according to Kaixuan Liu, MD, PhD, founder and president of Atlantic ...
(Date:7/20/2017)... , ... July 20, 2017 , ... ... protection services since 2014, top travel insurance solution company VisitorsCoverage Inc. has launched ... sell all major international travel insurance products online, under their own brand. The ...
(Date:7/20/2017)... ... July 20, 2017 , ... LINET, an international leader in healthcare ... product line: the AVE 2 birthing bed. , Perfectly suitable for labor, delivery, recovery ... of comfort and efficiency to every phase of childbirth. The AVE 2 has many ...
(Date:7/20/2017)... ... July 19, 2017 , ... Dr. Jig Patel is pleased to announce openings ... without a referral. Understanding the difficulties that face people who are missing teeth ... permanent alternative to removable dentures and bridges. Not only does an implant improve oral ...
Breaking Medicine News(10 mins):
(Date:6/20/2017)... Inc. (NYSE: HRC), will host its fiscal third quarter 2017 ... beginning at 7:30 a.m. (CDT) / 8:30 a.m. (EDT). ... the conference call, dial (877) 304-8969 (domestic) or (631) 291-4543 ... prior to the start to allow time to connect. The ... Webcast: A simultaneous webcast of the call will be ...
(Date:6/16/2017)... Datascope Corp. is voluntarily performing a worldwide field correction of certain Intra-Aortic Balloon ... ... CS100i ... 0998-UC-0446HXX; 0998-UC-0479HXX 0998-00-3013-XX;  0998-UC-3013-XX 0998-00-3023-XX;  ... This field correction also applies to any System 98 ...
(Date:6/14/2017)... Va. , June 14, 2017  ivWatch LLC, ... and effectiveness of intravenous (IV) therapy, is pleased to ... the category of Nonsurgical Hospital Supplies and Equipment at ... awards program for the medtech industry. The award was ... the Jacob K. Javits Center in New ...
Breaking Medicine Technology: