Navigation Links
Micro-RNA's contribute to risk for panic disorder
Date:3/24/2011

Philadelphia, PA, 24 March 2011 - Studies in twin pairs suggest that 40% of the risk for panic disorder is heritable, yet the manner in which genes contribute to the risk for panic disorder is far from clear. To date, variations in a growing number of genes have been implicated in the risk for panic disorder, but the magnitude of the impact of each individual gene is relatively small.

The pattern of these implicated genes raises the question of whether there might be molecular "switches" that control the function of groups of genes in a coordinated fashion, which would help to explain the observed findings related to the genetics of panic disorder.

A new study published in the current issue of Biological Psychiatry now implicates one type of molecular switch, microRNAs (miRNAs), in panic disorder.

Ribonucleic acid (RNA) is the immediate product of DNA. The most commonly discussed products of RNA are proteins, hence the common dictum "DNA makes RNA and RNA makes protein." However, miRNAs are small bits of RNA that bind to DNA and control the expression of various genes. There are a large number of miRNAs that have diverse effects on gene expression.

Through case-control studies in three different populations, from Spain, Finland and Estonia, Muios-Gimeno, Espinosa-Parrilla and colleagues found that at least four miRNAs (miR-22, miR-138-2, miR-148a and miR-488) may be involved in the pathophysiology of panic disorder. Their subsequent functional studies revealed that miR-138-2, miR-148a and miR-488 repress several candidate genes for panic disorder including GABRA6, CCKBR and POMC, respectively, and that miR-22 regulates four other candidate genes: BDNF, HTR2C, MAOA and RGS2. Their analysis also implicated miR-22 and miR-488 in the regulation of anxiety related pathways in the brain.

"These data provide important new evidence that variation in genes coding for miRNAs may coordinate the involvement of a number of risk genes and there
'/>"/>

Contact: Chris Pfister
c.pfister@elsevier.com
215-239-3266
Elsevier
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Antioxidants in pecans may contribute to heart health and disease prevention
2. Warm Homes in Winter May Contribute to Obesity Epidemic
3. Parents Divorce May Contribute to Suicidal Thoughts Years Later
4. Smog Contributes to Dangerous Heart Rhythm Disorders
5. Structure deep within the brain may contribute to a rich, varied social life
6. Citywide smoking ban contributes to significant decrease in maternal smoking, pre-term births
7. Cancer news articles may contribute to confusion about cancer
8. Housing Woes May Contribute to Poor Health
9. Newly discovered regulatory mechanism essential for embryo development and may contribute to cancer
10. Cigarette smoke may contribute to lung inflammation through a new chemical pathway
11. Violence in inner city neighborhoods contributes to trouble with asthma
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/27/2014)... 27, 2014 Locating an approximate price ... to present personal information before rates would be viewable. ... life insurance quotes are distributed online using its policy ... plans that an adult has access to review using ... companies. The system for quotation distribution built in 2013 ...
(Date:8/27/2014)... Spring, Md. (PRWEB) August 27, 2014 ... (CHEST) recently released guidelines for the management and ... Pharmacological Therapy for Pulmonary Arterial Hypertension in Adults: ... are free to view for clinicians, and provide ... PAH. , The Pulmonary Hypertension Association ...
(Date:8/27/2014)... decline in the use of hormone therapy has spawned ... suffering in silence with hot flashes, according to a ... colleagues. , In the study published in the ... , the team found that moderate to severe hot ... not treated in most women. Women with VMS experience ...
(Date:8/27/2014)... Ticket Down is a dependable source for ... in Santa Clara. Levi’s Stadium is a brand new ... July and will host their first international soccer match on ... two of the best teams that are both coming off ... to continue their successes from the tournament in this international ...
(Date:8/27/2014)... 2014 Sound Telecom, a leading telecommunications ... cloud-based business communication systems, has unveiled an article titled ... Secure Text Messaging .” The piece examines the world ... do to remain compliant with HIPAA and HITECH requirements. ... and C.O.O. at Sound Telecom, opens with evidence that ...
Breaking Medicine News(10 mins):Health News:Life Insurance Quotes for Term Policies Now Found at Insurer Website Online 2Health News:Pulmonary Hypertension Association Endorses CHEST Guidelines for Treatment of Pulmonary Arterial Hypertension in Adults 2Health News:The high cost of hot flashes: Millions in lost wages preventable 2Health News:Mexico vs. Chile Tickets at Levi’s Stadium: Ticket Down Cuts Ticket Prices for Inaugural Soccer Match between Chile and Mexico in Santa Clara 2Health News:Mexico vs. Chile Tickets at Levi’s Stadium: Ticket Down Cuts Ticket Prices for Inaugural Soccer Match between Chile and Mexico in Santa Clara 3Health News:Sound Telecom Releases Article on Secure Messaging with Huge Implications for the Healthcare Industry 2Health News:Sound Telecom Releases Article on Secure Messaging with Huge Implications for the Healthcare Industry 3
... ... Are Being Challenged , ... Provo, UT (Vocus) March 9, 2010 -- Tahitian Noni International (TNI) ... the network marketing industry. TNI believes that their Tahitian Noni® Original Bioactive Beverage™ is ...
... ... billion in subsidies over five years for making “meaningful use” of certified Electronic Medical ... ... 2010 -- Under the American Recovery and Reinvestment Act (ARRA) hospitals and physicians can ...
... ... Honest Tea, Hypertherm, RSM McGladrey, and Northeast Delta Dental join mission, in the most ... a wide range of workers., , ... (PRWEB) March 9, 2010 -- Flex-Friendly, which promotes workplace flexibility and ...
... ... ... ... ...
... people make up approximately 13 percent of the ... understanding its disability status and employment characteristics becomes ... disabilities make important contributions to our society, and ... range of impairments. A new study by researchers ...
... ... pain-relief that doesn,t come in traditional drug-form. With the launch of Oram Plus, developer Daniel ... ... done it again with the development of his new gum disease treatment, Oram Plus., , ...
Cached Medicine News:Health News:$250,000 Bioactive Beverage Challenge Announced By Tahitian Noni International 2Health News:$250,000 Bioactive Beverage Challenge Announced By Tahitian Noni International 3Health News:Three Security Firms Create Consortium To Automate Meaningful Use Requirements And Qualify Clients For $Billions In Stimulus Funds 2Health News:Three Security Firms Create Consortium To Automate Meaningful Use Requirements And Qualify Clients For $Billions In Stimulus Funds 3Health News:New Gender-Neutral Flex-Friendly Certification Makes the Business Case for Flex Even in a Tough Economy. 2Health News:New Gender-Neutral Flex-Friendly Certification Makes the Business Case for Flex Even in a Tough Economy. 3Health News:New Gender-Neutral Flex-Friendly Certification Makes the Business Case for Flex Even in a Tough Economy. 4Health News:New Gender-Neutral Flex-Friendly Certification Makes the Business Case for Flex Even in a Tough Economy. 5Health News:Quantros Releases Video in Recognition of National Patient Safety Week 2Health News:Quantros Releases Video in Recognition of National Patient Safety Week 3Health News:Immigrants with disabilities more frequently employed than US-born persons with disabilities 2Health News:Oram Plus Set to Take the Pain out of Gum Disease and Cavities, Naturally 2
(Date:8/27/2014)... Reportlinker.com announces that a new market ... Global Orthopedic Soft Tissue Repair Devices Market ... About Orthopedic Soft Tissue Repair Devices ... that connect, support, or surround bones. There are ... tendons, ligaments, cartilage, fascia, and other fibrous tissues. ...
(Date:8/27/2014)... 27, 2014 According to ... Radiology, CAD/CAM, Dental Chairs, Dental Lasers), Current Trends, Opportunities ... global Dental Equipment Market is expected to reach ... 2014, growing at a CAGR of 5.7% between ... data tables and 61 figures spread through 167 ...
(Date:8/27/2014)... , Aug. 27, 2014 Pulse Systems, ... (EHR) , Practice Management , and Revenue Cycle ... known business practices performed by some RCM vendors, at UBM ... PA on September 19-20, 2014.  ... will return in September with a new session encouraging practices ...
Breaking Medicine Technology:Global Orthopedic Soft Tissue Repair Devices Market 2014-2018 2Global Orthopedic Soft Tissue Repair Devices Market 2014-2018 3Global Orthopedic Soft Tissue Repair Devices Market 2014-2018 4Global Orthopedic Soft Tissue Repair Devices Market 2014-2018 5Dental Equipment Market Worth $7,138.9 Million by 2019 2Dental Equipment Market Worth $7,138.9 Million by 2019 3Pulse Systems Presents the Truth about Revenue Cycle Management Services at Practice Rx 2Pulse Systems Presents the Truth about Revenue Cycle Management Services at Practice Rx 3Pulse Systems Presents the Truth about Revenue Cycle Management Services at Practice Rx 4
... YORK, Sept. 9 New York Blood Center (NYBC), serving ... Island, the Hudson Valley and New Jersey, calls upon our ... and Labor Day holiday weekend have resulted in fewer donations ... B-negative blood for patients in need. Donations from ...
... Polycystic Ovarian Syndrome, known as PCOS, is a silent ... body and increases the risk of serious illness. ... and increases the risk of heart disease, insulin resistance, diabetes ... abnormality in women of child bearing age, affecting 5 to ...
Cached Medicine Technology:Blood Donors Needed as School, Fall Season Returns 2Blood Donors Needed as School, Fall Season Returns 3Detailed Cholesterol Test Provides Vital Clues for Women in Search of PCOS Answers 2Detailed Cholesterol Test Provides Vital Clues for Women in Search of PCOS Answers 3
... super series slit ... Examination through small ... fundus diagnostic capability, ... potential field of ...
... Volk's super ... biomicroscopy lenses. General ... Provide unprecedented fundus ... addressing maximum potential ...
Volk indirect lenses. General diagnosis / small pupil examinations....
Volk indirect lenses. General diagnosis & treatment....
Medicine Products: