Navigation Links
Micro-RNA determines malignancy of lung cancer
Date:9/8/2010

Cancer becomes life-threatening when tumor cells start leaving their primary site. They travel through the lymph and blood streams to other tissues where they grow into metastases. This transition to malignancy is associated with characteristic changes in the cancer cells. The activity of several genes is reprogrammed and, thus, the production of proteins anchoring cells to a tissue is reduced. On the other hand, the amount of surface markers which make a cancer cell mobile increases.

Professor Dr. Heike Allgayer heads a Clinical Cooperation Unit of DKFZ and UMM. She is an expert for those cellular processes that lead to metastasis in cancer. In recent years, scientists have discovered that production of many proteins is regulated by what are called micro-RNAs. These RNA molecules, which consist of only about 23 building blocks, attach specifically to messenger RNAs, which contain the blueprints for proteins. In this way, they block the production of the respective protein.

"We believe that micro-RNAs also play an important role in metastasis and that they program cells in a way that leads to malignant growth," medical researcher Heike Allgayer explains. In an international collaboration with researchers in Turin, Italy, Allgayer and her team used various cell lines of non-small cell lung cancer to investigate a particularly suspicious candidate called miR-200c and its role in malignant growth. The research team found out that the less miR-200c is produced by a cell line, the higher its motility and its capacity to invade surrounding tissue. When the researchers experimentally equipped the cancer cells with additional miR-200c, the amount of tissue-anchoring molecules on their surface increased and their invasive capacity became lower. In animal experiments, these cells produced less metastasis.

A dreaded characteristic of non-small cell lung cancer is its resistance to chemotherapy and targeted anticancer drugs. A lack of miR-200c also seems to play a role here. Therapy-resistant lung cancer cell lines that were experimentally equipped with miR-200c could subsequently be killed by the chemotherapy drug cisplatin and responded to cetuximab, a drug that block growth signals.

Allgayer's Team also discovered how the loss of miR-200c is brought about in cancer cells. In the highly aggressive cells, the miR-200c genes are turned off by chemical labeling with methyl groups. Drugs that remove these labels made the production of miR-200c rise again.

Studying the tumor cells of 69 lung cancer patients, the investigators realized that miR-200c not only plays a role in the culture dish. They determined miR-200c levels and compared these with the patients' disease progression data. The lower the miR-200c level in the cancer cells, the more frequently metastasis had already begun. "Our results clearly show a connection between a loss of miR-200c and transition to aggressive, invasive growth, metastasis and chemoresistance," Heike Allgayer summarizes. "Therefore, we will now investigate whether miR-200c production in cancer cells can be used for predicting metastasis and, thus, may serve as a prognosis factor for the progression of a lung cancer. It is also possible that the miR-200c level can help to better predict the effectiveness of particular drugs."


'/>"/>

Contact: Dr. Sibylle Kohlstaedt
s.kohlstaedt@dkfz.de
Helmholtz Association of German Research Centres
Source:Eurekalert

Related medicine news :

1. Location determines social network influence, CCNY-led team finds
2. Childrens sense of threat from parental fighting determines trauma symptoms
3. TNF blockers may increase the risk of malignancy in children
4. Indeterminate breast lesions found in high-risk patients should be evaluated aggressively to exclude malignancy
5. Women with radial scars should undergo a surgical excision to rule out an underlying malignancy
6. Magic Mushroom Hallucinogen Might Help Cancer Patients
7. Multivitamin use doesnt impact colon cancer outcomes
8. St. Jude researcher receives grant to focus on cancer pharmacogenomics in children
9. New robotic head and neck cancer surgery preserves speech, without scarring
10. LA BioMed research finds hallucinogen can safely ease anxiety in advanced-stage cancer patients
11. Hallucinogen appears safe, may improve mood among patients with advanced-stage cancer and anxiety
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... As health ... medicine known as “patient engagement.” The patient is doing more than filling out a ... , “There is an increasing emphasis in health care and research on the ...
(Date:10/13/2017)... , ... October 13, 2017 ... ... of Pharmacy (SOP) alumni Hannah Randall, PharmD ‘17, and Jennifer Huggins, PharmD ... on guideline updates for the primary prevention of cardiovascular diseases during the ...
(Date:10/13/2017)... NY (PRWEB) , ... October 13, 2017 , ... Ellevate ... people in business to advocate for action towards gender equality at their inaugural Summit ... from around the globe, and reached a social audience of over 3 million. To ...
(Date:10/13/2017)... , ... October 13, 2017 , ... “The Journey: From ... every danger possible to save lost souls in the Philippines. “The Journey: From the ... is a dedicated teacher of the Bible. She has taught all ages and currently ...
(Date:10/12/2017)... ... October 12, 2017 , ... The company has ... today’s consumer and regulatory authorities worldwide. From Children’s to Adults 50+, every formula ... the highest standard. , These products are also: Gluten Free, Non-GMO, Vegan, ...
Breaking Medicine News(10 mins):
(Date:9/25/2017)... PROVIDENCE, R.I. , Sept. 25, 2017 /PRNewswire/ ... immunogenicity assessment, vaccine design, and immune-engineering today announced ... focused on the development of personalized therapeutic cancer ... and has provided exclusive access to enabling technologies ... MSc Eng., MBA will lead EpiVax Oncology as ...
(Date:9/19/2017)... , Sept. 19, 2017   ZirMed Inc ., a ... today announced that it has been ranked #1 by its ... Book™ Rankings 2017 User Survey. ZirMed was recognized as ... large hospitals and medical centers over 200 beds and holds ... healthcare technology user survey history. ...
(Date:9/12/2017)... N.J. , Sept. 12, 2017  Consumer reviews on the ... Hearing as the number one company for hearing aids, ranking ... and fifteen other brands. ... Embrace Hearing Named #1 by Consumers For Hearing Aids ... Embrace Hearing is an online store that provides high ...
Breaking Medicine Technology: