Navigation Links
Micro-RNA determines malignancy of lung cancer
Date:9/8/2010

Cancer becomes life-threatening when tumor cells start leaving their primary site. They travel through the lymph and blood streams to other tissues where they grow into metastases. This transition to malignancy is associated with characteristic changes in the cancer cells. The activity of several genes is reprogrammed and, thus, the production of proteins anchoring cells to a tissue is reduced. On the other hand, the amount of surface markers which make a cancer cell mobile increases.

Professor Dr. Heike Allgayer heads a Clinical Cooperation Unit of DKFZ and UMM. She is an expert for those cellular processes that lead to metastasis in cancer. In recent years, scientists have discovered that production of many proteins is regulated by what are called micro-RNAs. These RNA molecules, which consist of only about 23 building blocks, attach specifically to messenger RNAs, which contain the blueprints for proteins. In this way, they block the production of the respective protein.

"We believe that micro-RNAs also play an important role in metastasis and that they program cells in a way that leads to malignant growth," medical researcher Heike Allgayer explains. In an international collaboration with researchers in Turin, Italy, Allgayer and her team used various cell lines of non-small cell lung cancer to investigate a particularly suspicious candidate called miR-200c and its role in malignant growth. The research team found out that the less miR-200c is produced by a cell line, the higher its motility and its capacity to invade surrounding tissue. When the researchers experimentally equipped the cancer cells with additional miR-200c, the amount of tissue-anchoring molecules on their surface increased and their invasive capacity became lower. In animal experiments, these cells produced less metastasis.

A dreaded characteristic of non-small cell lung cancer is its resistance to chemotherapy and targeted anticancer drugs. A lack of miR-200c also seems to play a role here. Therapy-resistant lung cancer cell lines that were experimentally equipped with miR-200c could subsequently be killed by the chemotherapy drug cisplatin and responded to cetuximab, a drug that block growth signals.

Allgayer's Team also discovered how the loss of miR-200c is brought about in cancer cells. In the highly aggressive cells, the miR-200c genes are turned off by chemical labeling with methyl groups. Drugs that remove these labels made the production of miR-200c rise again.

Studying the tumor cells of 69 lung cancer patients, the investigators realized that miR-200c not only plays a role in the culture dish. They determined miR-200c levels and compared these with the patients' disease progression data. The lower the miR-200c level in the cancer cells, the more frequently metastasis had already begun. "Our results clearly show a connection between a loss of miR-200c and transition to aggressive, invasive growth, metastasis and chemoresistance," Heike Allgayer summarizes. "Therefore, we will now investigate whether miR-200c production in cancer cells can be used for predicting metastasis and, thus, may serve as a prognosis factor for the progression of a lung cancer. It is also possible that the miR-200c level can help to better predict the effectiveness of particular drugs."


'/>"/>

Contact: Dr. Sibylle Kohlstaedt
s.kohlstaedt@dkfz.de
Helmholtz Association of German Research Centres
Source:Eurekalert

Related medicine news :

1. Location determines social network influence, CCNY-led team finds
2. Childrens sense of threat from parental fighting determines trauma symptoms
3. TNF blockers may increase the risk of malignancy in children
4. Indeterminate breast lesions found in high-risk patients should be evaluated aggressively to exclude malignancy
5. Women with radial scars should undergo a surgical excision to rule out an underlying malignancy
6. Magic Mushroom Hallucinogen Might Help Cancer Patients
7. Multivitamin use doesnt impact colon cancer outcomes
8. St. Jude researcher receives grant to focus on cancer pharmacogenomics in children
9. New robotic head and neck cancer surgery preserves speech, without scarring
10. LA BioMed research finds hallucinogen can safely ease anxiety in advanced-stage cancer patients
11. Hallucinogen appears safe, may improve mood among patients with advanced-stage cancer and anxiety
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/24/2017)... (PRWEB) , ... May 24, 2017 , ... ... dental implants in Bayside, NY, who have now spent 10 years as clinical ... New York University (NYU) College of Dentistry. Through the program, private practitioners receive ...
(Date:5/24/2017)... ... May 24, 2017 , ... Patients who want to receive ... now meet with Dr. Joseph Bedich for a consultation, with or without a referral. ... oral health and functionality. , Dr. Bedich offers a variety of cosmetic ...
(Date:5/24/2017)... ... May 24, 2017 , ... Myers Jackson is well known for ... to sell luxury homes anywhere on the planet. The luxury home market is alive ... to Houston city-scapes. A quick search of “11 Spyglass Hill Auction will enlighten you ...
(Date:5/24/2017)... , ... May 24, 2017 ... ... the female reproductive tract in which the endometrial lining of the uterus ... inflammation and pain. Patients experiencing painful intercourse, painful periods, pelvic pain, or ...
(Date:5/24/2017)... ... May 24, 2017 , ... Accordant Technology, ... solutions portfolio. ExtraHop delivers an analytics-first approach, layered with machine learning, that provides ... the datacenter to the cloud to the edge. Through the new partnership, customers ...
Breaking Medicine News(10 mins):
(Date:5/3/2017)... WAYNE, N.J. , May 3, 2017 /PRNewswire/ ... systems that contribute to quality enhancement and cost ... results from a study of contemporary practice demonstrating ... a first-line therapy for critically ill patients. The ... the Company,s newer large volume MEGA ® ...
(Date:5/2/2017)... YORK and LONDON , ... of market intelligence, MarketResearch.com is pleased to announce a ... AB that allows for the marketing and distribution ... analyses through the MarketResearch.com website. The new ... to complete product descriptions and tables of contents from ...
(Date:5/2/2017)... , May 2, 2017  CIVCO Radiotherapy, the ... solutions, announced today that Nat Geissel ... CIVCO since 2012 and has served as vice ... vice president and general manager, and most recently, ... "I am extremely proud of what CIVCO Radiotherapy ...
Breaking Medicine Technology: