Navigation Links
Michael J. Fox Foundation Awards $3.8 Million To Drive Nine Industry Partnerships For Pre-Clinical Parkinson's Drug Development

NEW YORK, July 21 /PRNewswire-USNewswire/ -- The Michael J. Fox Foundation for Parkinson's Research has awarded research teams at nine biotech and pharmaceutical companies a total of $3.8 million for pre-clinical Parkinson's drug development projects. Funded investigations aim to push forward novel neuroprotective and improved symptomatic therapies as well as new strategies for addressing complications of treatment.

While MJFF accepts applications from industry under all of its programs, the Therapeutics Development Initiative (TDI) - first launched in 2006 - is the Foundation's only industry-exclusive funding stream. It is a key element of MJFF's strategy to 'de-risk' preclinical PD research for biotech and pharmaceutical companies, thus expanding industry investment in Parkinson's therapeutic development and helping push the most promising research to the next stage.

Projects selected for funding are listed below. Detailed information, including grant abstracts and researcher bios, is available on the Foundation's Searchable Database of Funded Grants. As with all MJFF grants, full funding is contingent on the achievement of predetermined, specific milestones and on researchers' agreement to make the results of their work available to the Parkinson's research community.

Neuroprotective Approaches

Pharmacodynamics of ReS9-S7, a first-in-class, disease-modifying drug candidate for treatment of Parkinson's disease

Gerard Griffioen, PhD, NV reMYND, Leuven, Belgium

Exploring curcumin and curcumin derivatives as putative epigenetic targets of histone deacetylase (HDAC) inhibition in Parkinson's disease

Lawrence Helson, MD, Sign Path Pharma, Inc., Quakertown, Pennsylvania

Assessment of the therapeutic efficacy of progranulin in a sub-chronic animal model of Parkinson's disease

Denis Kay, PhD, Neurodyn, Inc., Charlottetown, Prince Edward Island, Canada

Validation of LRRK2 as a drug target for treatment of Parkinson's disease using antisense technology

Alejandro Lloret, PhD, Isis Pharmaceuticals, Inc., Carlsbad, California

Optimizing lead series of small molecule inhibitors of LRRK2 to deliver tool compounds and clinical development candidates

Alastair D. Reith, PhD, GlaxoSmithKline, United Kingdom

A novel approach to characterize the distribution of a potentially therapeutic dominant-negative inhibitor of tumor necrosis factor in pre-clinical models of PD, and predict the scalability for an effective delivery of therapy in the human brain

Lisa Lynn Shafer, PhD, Medtronic Neuromodulation, Minneapolis, Minnesota

Pre-clinical development of a Parkinson's disease therapy using a glucagon-like peptide (GLP-1) receptor agonist

Kevin Tomaselli, PhD, Amylin Pharmaceuticals, Inc., San Diego, California

Symptomatic Approaches/Complications of Treatment

Effect of novel neuronal nicotonic receptor compounds on treatment of levodopa-induced dyskinesia in Parkinson's disease

Kristen Jordan, PhD, Targacept, Winston-Salem, North Carolina

Optimization of MOR antagonists for the treatment of L-DOPA-induced dyskinesias in Parkinson's disease

Patrick Little, PhD, Adolor Corporation, Exton, Pennsylvania

TDI is launched bi-annually with applications accepted each spring and fall. It has been enthusiastically received by industry researchers. To date the Foundation has awarded $16.5 million total for 33 industry-led projects under the initiative.

About The Michael J. Fox Foundation

The Michael J. Fox Foundation is dedicated to finding a cure for Parkinson's disease through an aggressively funded research agenda and to ensuring the development of improved therapies for those living with Parkinson's today. To date, the Foundation has funded $149 million in research. For more information on TDI and the Foundation's industry strategy, please visit

SOURCE Michael J. Fox Foundation
Copyright©2009 PR Newswire.
All rights reserved

Related medicine news :

1. Michael Moores SiCKO Becomes the Third Highest Grossing Documentary of All Time Surpassing An Inconvenient Truth
2. Katie Hood Appointed Interim Chief Executive Officer of Michael J. Fox Foundation
3. Clarient Names Michael J. Pellini, M.D. Chief Operating Officer
4. Digital Healthcare Announces Dr. Michael Fleming Joins Executive Team as Medical Director
5. Michael J. Fox Foundation Commits Up to $2 Million for PD Drug Development Under Target Validation 2008
6. BioElectronics Corporation Announces Addition of Michael Seidenman, R.Ph. as Vice President of Sales
7. BioSeek Appoints Michael C. Venuti, Ph.D., Chief Executive Officer
8. Irene Hegeman Richard, MD, Appointed Senior Medical Advisor to The Michael J. Fox Foundation
9. Actress Jenifer Lewis, Authors Dr. Michael Eric Dyson and Susan Taylor Among Featured Speakers for Senator Hughes Behavioral Mental Health Summit
10. Michael J. Fox Foundation Launches Rapid Response Innovation Awards 2008 Following Strong Inaugural Year Response
11. Siemens Medical Solutions Michael Long Recognized as one of Computerworlds 2008 Premier 100 IT Leaders
Post Your Comments:
(Date:6/25/2016)... ... ... As a lifelong Southern Californian, Dr. Omkar Marathe earned his Bachelors in ... School of Medicine at UCLA. He trained in Internal Medicine at Scripps Green Hospital ... at the UCLA-Olive View-Cedars Sinai program where he had the opportunity to train in ...
(Date:6/24/2016)... ... June 24, 2016 , ... A recent article published June ... with. The article goes on to state that individuals are now more comfortable seeking ... common operations such as calf and cheek reduction. The Los Angeles area medical group, ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... ... Conference and Scientific Sessions in Dallas that it will receive two significant new ... the grants came as PHA marked its 25th anniversary by recognizing patients, medical ...
(Date:6/24/2016)... ... 24, 2016 , ... Topical BioMedics, Inc, makers of Topricin and MyPainAway Pain Relief Products, join ... wage raise to $12 an hour by 2020 and then adjusting it yearly to increase ... of the minimum wage, assure the wage floor does not erode again, and make future ...
(Date:6/24/2016)... ... June 24, 2016 , ... ... Investment Group (TGIG), has initiated cultivation and processing operations at its production facility, ... Pahrump, Nevada. , Puradigm is the manufacturer of a complete system of proactive ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... , June 23, 2016 Roche (SIX: ... 510(k) clearance for its Elecsys BRAHMS PCT (procalcitonin) assay ... sepsis or septic shock. With this clearance, Roche is ... a fully integrated solution for sepsis risk assessment and ... with bacterial infection and PCT levels in blood can ...
(Date:6/23/2016)... Calif. , June 23, 2016 ... CST on Thursday, July 7, 2016 , , , , ... ) , , , , EXPERT PANELISTS:  , , ... Naik; Senior Industry Analyst, Christi Bird; Senior Industry Analyst, Divyaa Ravishankar ... The global pharmaceutical industry is witnessing an exceptional ...
(Date:6/23/2016)... 2016 The vast majority of dialysis patients ... Treatments are usually 3 times a week, with treatment ... travel time, equipment preparation and wait time.  This regimen ... for patients who are elderly and frail.  Many elderly ... rehabilitation centers for some duration of time. ...
Breaking Medicine Technology: