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Michael J. Fox Foundation Awards $2 Million for Clinical Research on Postural Instability and Gait Disturbances in Parkinson's Disease
Date:12/28/2009

rol gait. They will also investigate whether freezing can be alleviated through repetitive transcranial magnetic stimulation (rTMS) of one of these regions, the posterior parietal cortex (PPC). rTMS is a non-invasive method for stimulating specific areas of the brain surface through the skull.
  • A team based in Sydney, Australia, will use functional magnetic resonance imaging (fMRI) in a virtual environment to safely trigger freezing episodes while visualizing patients' brains. The researchers aim to more fully establish which regions of the brain are activated during freezing in order to open new doors to the development of treatments.
  • As with all MJFF awards, continued funding is dependent on researchers' achieving predetermined milestones. A full list of awardees is below. Grant abstracts and researchers' biosketches are available at www.michaeljfox.org.

    Role of the Posterior Parietal Cortex and Pedunculopontine Nucleus in the Pathopysiology of Freezing of Gait: An MRI and TMS study

    Julien Cremers, MD, University Hospital of Liege and Belgian National Fund for Scientific Research

    The Role of White Matter Pathology in the Development of the Postural Instability and Gait Disturbance (PIGD) Type of Parkinson's disease

    Jeffrey Hausdorff, Tel-Aviv Sourasky Medical Center, Israel

    Determining the Neural Correlates of Freezing of Gait in Parkinson's Disease Using Functional Magnetic Resonance Imaging (fMRI)

    Simon Lewis, MD, Parkinson's Disease Research Clinic, Brain & Mind Research Institute, University of Sydney, Australia

    Relationship between REM Behavior Disorder and Freezing of Gait in Parkinson's Disease

    Colum
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    SOURCE Michael J. Fox Foundation
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