Navigation Links
Michael J. Fox Foundation Awards $2.8 Million to Drive Development of Parkinson's Disease Biomarker Pipeline
Date:2/4/2010

NEW YORK, Feb. 4 /PRNewswire-USNewswire/ -- The Michael J. Fox Foundation for Parkinson's Research today announced more than $2.8 million in awards for 13 new projects to speed the discovery of biomarkers of PD. The development of biomarkers is of critical importance to increasing the speed and efficiency of PD therapeutic development, allowing scientists and clinicians to more accurately identify appropriate subjects for clinical studies, measure disease progression and monitor treatment effects in clinical trials.

The lack of clear and reliable biomarkers of PD is one of the greatest hurdles to developing and testing new treatments that slow, stop or even prevent the disease — a key unmet need for Parkinson's patients.  In addition to improving the ability of researchers to diagnose PD and measure its progression, the identification of biomarkers would also help to provide more definitive outcomes from clinical trials.

In a paper published in the April 2009 edition of Neurology, David Vaillancourt, PhD, of the University of Illinois at Chicago, demonstrated that a type of MRI imaging technique known as diffusion tensor imaging (DTI) can distinguish people with early-stage PD from people without the disease. Now with MJFF funding, Dr. Vaillancourt is working to determine if DTI can differentiate PD from other neurological movement disorders to provide additional evidence for the use of DTI as a PD biomarker. In a separate but related longitudinal study, Tanya Simuni, MD, of Northwestern University is testing whether DTI can be used as a marker of PD progression by tracking whether DTI detects changes in people with Parkinson's disease over time.

The development of drug biomarkers is also critical to provide researchers with a tool for conclusively assessing whether a given drug is reaching brain areas of interest and/or achieving its desired effect. Danna Jennings, MD, of the Institute for Neurodegenerative Disorders is working with a brain imaging molecule that can be used as a biomarker for drugs targeting a glutamate receptor in the brain known as mGluR5. Drugs that block mGluR5 (antagonists) have been shown in pre-clinical models to reduce dyskinesias, the involuntary movements that are a debilitating side effect of dopamine replacement therapy to treat PD. Dr. Jennings will use the imaging molecule to confirm that a clinically approved mGluR5 antagonist is reaching the brain at appropriate levels and to determine the most effective dose of the drug for use in future PD clinical trials.

The following is a complete list of funded projects, which are made possible through the generous support of The Brin Wojcicki Foundation. Grant abstracts and researcher bios are available on the Foundation's Web site, www.michaeljfox.org.

T-Cell Receptor Changes as a Biomarker of Parkinson's Disease

Chuanhai Cao, PhD, University of South Florida, College of Medicine

Analysis of the Enteric Nervous System Using Routine Colonoscopy Biopsies: a Biomarker of Neurodegeneration in Parkinson's Disease?

Pascal Derkinderen, MD, PhD, Department of Neurology, Inserm U913, Nantes, France

QE3 Trial Ancillary Biomarkers Study

Claire Henchcliffe, MD, DPhil, Weill Medical College of Cornell University

Development of an mGluR5 Imaging Marker for Parkinson's Disease

Danna V. Jennings, MD, Institute for Neurodegenerative Disorders

Assessing Heart Rate Variability in the Parkinson's Associated Risk Study Cohort

J. William Langston, MD, The Parkinson's Institute

Validating the Electrocardiogram as a Tool to Identify Pre-Motor Parkinson's Disease

J. William Langston, MD, The Parkinson's Institute

Validation of Neuroimaging Biomarkers for Nigrostriatal Neurons

Joel S. Perlmutter, MD, Washington University in St. Louis

The Role of Striatal Serotonergic Terminals in L-Dopa Induced-Dyskinesia in PD Patients

Paola Piccini, MD, PhD, FRCP, Imperial College London, England

Raising Antibodies to Alpha-Synuclein

Michael Schlossmacher, MD, University of Ottawa, Ontario, Canada

Biomarkers of Pioglitazone Effects in PD

David K. Simon, MD, PhD, Beth Israel Deaconess Medical Center (Harvard Medical School)

High Resolution Diffusion Tensor MRI Imaging as a Biomarker of Parkinson's Disease Diagnosis and Disease Progression

Tanya Simuni, MD, Northwestern University

High Resolution Diffusion Tensor Imaging in Parkinson's Disease and Parkinson's Plus Syndromes

David E. Vaillancourt, PhD, University of Illinois at Chicago

Development of alpha6-selective Neuronal Nicotinic Receptor Imaging Agent as a Parkinson's Disease Biomarker

Daniel Yohannes, PhD, Targacept, Inc.

The Michael J. Fox Foundation has been a leader in the development of PD biomarkers for several years, with investments of nearly $23 million to date. Recognizing the critical need for an orchestrated, fieldwide strategy to drive tangible progress, MJFF is also launching a comprehensive biomarker discovery and verification effort in 2010.


The Michael J. Fox Foundation is dedicated to ensuring the development of better treatments, and ultimately a cure, for Parkinson's disease through an aggressively funded research agenda. MJFF has funded over $170 million in research to date. 

SOURCE Michael J. Fox Foundation

RELATED LINKS
http://www.michaeljfox.org/

'/>"/>

SOURCE Michael J. Fox Foundation
Copyright©2010 PR Newswire.
All rights reserved

Related medicine news :

1. Aleres Dr. Michael Taitel Presents Compelling Evidence at IBI/NBCH Health & Productivity Forum that Wellness Programs Positively Impact Health & Productivity
2. Michael Jackson Propofol Expert, Barry Friedberg MD, Spoke at Pan Pacific Surgery Meeting
3. TV Wellness Expert Jillian Michaels Teams With Harley-Davidson to Help Women Channel Their Inner Drive and Live More Fulfilling Lives
4. Michael J. Fox Foundation Awards $2 Million for Clinical Research on Postural Instability and Gait Disturbances in Parkinsons Disease
5. Michael J. Fox Foundation Awards $1 Million for Critical Step Toward Development of Dyskinesia Treatments
6. Rush Limbaugh & Michael Steele Join Tea Party Support & Social Security Institute-Demand GOP Senate Stop ObamaCare by Any Means Possible
7. Dr. Michael Aziz Releases a New Nutrition Book That Debunks Most Popular Diets and Diet Books
8. BIDMC scientists awarded grants from Michael J. Fox Foundation for Parkinsons research
9. Michael S. Burg Appointed as Co-Lead Counsel in the Yasmin/Yaz Multidistrict Litigation
10. Syracuse Attorney Michael P. Kenny Prepares Suit Against Sony Due to Client's Seizure Caused By Video Game
11. Majesco Entertainment and Interactive Game Group Release Jillian Michaels Fitness Ultimatum 2010 For Nintendo DS(TM)
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/5/2016)... (PRWEB) , ... February 05, 2016 , ... ... ranked #3 in the 2015 Best in KLAS: Software & Services for HIT ... annual Best in KLAS report independently ranks vendor performance by healthcare executives, managers ...
(Date:2/5/2016)... , ... February 05, 2016 , ... Stuart Bentkover, ... technology, the PicoSure. Designed to provide the most effective tattoo removal today, Dr. Bentkover ... unmatched results. , Developed by Cynosure, the PicoSure has been approved by the Food ...
(Date:2/5/2016)... ... 05, 2016 , ... In sleep, when the defenses of the day are ... of patients with eating disorders is significant self-criticism, and consequently these patients experience this ... regarded as maladaptive means for coping with this unease, but also leads to a ...
(Date:2/5/2016)... ... February 05, 2016 , ... On June 9-10, Las ... continuing medical education (CME) event presented by the Association for Comprehensive Care in ... for ACCORD, whose mission is to provide education, tools, and resources to primary ...
(Date:2/5/2016)... ... ... –This week, Atascadero water heater company First Call Plumbing has ... the report, click here or see below. , There are two ... cons, the type chosen is almost entirely up to personal preference. However, tankless water ...
Breaking Medicine News(10 mins):
(Date:2/5/2016)... , Feb. 5, 2016  Syneron Medical Ltd. ... device company, announced today that William Griffing ... America, is scheduled to participate in the Leerink ... on February 11, 2016 in New ... institutional investors to meet with the Mr. Griffing ...
(Date:2/5/2016)... 2016 http://www.researchandmarkets.com/research/jsc97m/global ... "Global Musculoskeletal Partnering 2010-2016: Deal trends, ... their offering. --> http://www.researchandmarkets.com/research/jsc97m/global ... "Global Musculoskeletal Partnering 2010-2016: Deal trends, ... their offering. --> Research ...
(Date:2/5/2016)... , Feb. 5, 2016  Zimmer Biomet Holdings, Inc. ... the previously announced underwritten secondary offering of 11,027,558 shares ... consisting of affiliates of Blackstone and Goldman Sachs.  The ... initial price of $96.45 per share. The selling stockholders ...  Neither Zimmer Biomet nor any of its directors, officers ...
Breaking Medicine Technology: