Navigation Links
Michael J. Fox Foundation Awards $1.1 Million For Clinical Trial of Transdermal Nicotine as Disease-Modifying Treatment For Parkinson's
Date:2/18/2010

German-American consortium to test nicotine patch in 150 PD patients

NEW YORK, Feb. 18 /PRNewswire-USNewswire/ -- The Michael J. Fox Foundation announced that it has awarded $1.1 million for an international clinical trial vetting the potential of a nicotine skin patch to modify the progression of Parkinson's disease. The funding was made under the Clinical Intervention Awards initiative, one of MJFF's Edmond J. Safra Core Programs for PD Research.

This first-ever multisite, investigator-initiated collaboration between Parkinson's study groups in Germany and the United States will encompass a one-year double-blind, placebo-controlled trial in 150 newly diagnosed Parkinson's patients. Principal investigators Wolfgang H. Oertel and Marcus M. Unger of Philipps University Marburg, Germany, and Karl Kieburtz of the University of Rochester, New York, will evaluate the disease-modifying potential of transdermal nicotine using standard skin patches of the type used by millions of smokers as a quitting aid. The production of the patches being used in this trial has been supported by the pharmaceutical company Novartis.

While scientists have previously studied the symptomatic effects of nicotine in Parkinson's patients, this is the first long-term clinical trial expressly designed to test whether nicotine may in fact modify the progression of PD. Parkinson's researchers have long been intrigued by epidemiological research showing a possible link between cigarette smoking and a lowered risk of PD: the disease is far less prevalent among smokers compared to never-smokers. Nicotine also has demonstrated beneficial effects on PD in pre-clinical studies. Yet key questions about the relationship among smoking, nicotine and Parkinson's — including whether smoking tobacco products in fact confers protection and, if so, whether this protection stems from the nicotine in those products — remain unanswered.

Until this trial provides data on the safety profile of transdermal nicotine in never-smokers, the study leaders caution that patients should not introduce nicotine into their treatment regimen without the explicit recommendation of their doctor. The benefits of transdermal nicotine for PD have not yet been conclusively proven, and its safety for use in people who have never smoked remains unestablished. Trial participants will be closely monitored for any adverse health effects that may occur as a result of nicotine treatment.

The commercialization of a therapy capable of retarding or stopping the progression of Parkinson's disease — rather than merely masking symptoms while the underlying disease continues to worsen — would be a transformative event in the lives of the estimated 5 million Parkinson's patients worldwide. Transdermal nicotine holds the additional advantages of wide availability and relatively low cost.

As with all MJFF awards, continued funding is dependent on researchers' achieving predetermined milestones. Progress and outcome reports will be posted to the Foundation's Web site as they become available.

About The Michael J. Fox Foundation

The Michael J. Fox Foundation is dedicated to ensuring the development of better treatments, and ultimately a cure, for Parkinson's disease through an aggressively funded research agenda. MJFF has funded almost $176 million in research to date. 

SOURCE Michael J. Fox Foundation


'/>"/>
SOURCE Michael J. Fox Foundation
Copyright©2010 PR Newswire.
All rights reserved

Related medicine news :

1. Michael Moores SiCKO Becomes the Third Highest Grossing Documentary of All Time Surpassing An Inconvenient Truth
2. Katie Hood Appointed Interim Chief Executive Officer of Michael J. Fox Foundation
3. Clarient Names Michael J. Pellini, M.D. Chief Operating Officer
4. Digital Healthcare Announces Dr. Michael Fleming Joins Executive Team as Medical Director
5. Michael J. Fox Foundation Commits Up to $2 Million for PD Drug Development Under Target Validation 2008
6. BioElectronics Corporation Announces Addition of Michael Seidenman, R.Ph. as Vice President of Sales
7. BioSeek Appoints Michael C. Venuti, Ph.D., Chief Executive Officer
8. Irene Hegeman Richard, MD, Appointed Senior Medical Advisor to The Michael J. Fox Foundation
9. Actress Jenifer Lewis, Authors Dr. Michael Eric Dyson and Susan Taylor Among Featured Speakers for Senator Hughes Behavioral Mental Health Summit
10. Michael J. Fox Foundation Launches Rapid Response Innovation Awards 2008 Following Strong Inaugural Year Response
11. Siemens Medical Solutions Michael Long Recognized as one of Computerworlds 2008 Premier 100 IT Leaders
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... ... June 25, 2016 , ... Dr. Calvin Johnson ... Recently, he has implemented orthobiologic procedures as a method for treating his patients. ... the first doctors to perform the treatment. Orthobiologics are substances that orthopaedic surgeons ...
(Date:6/24/2016)... Marne, Michigan (PRWEB) , ... June 24, 2016 , ... ... To deal with these feelings, many turn to unhealthy avenues, such as drug or ... Center of Marne, Michigan, has released tools for healthy coping following a traumatic event. ...
(Date:6/24/2016)... MIAMI, Fla. (PRWEB) , ... June 24, 2016 , ... ... Florida Trend magazine’s 2016 Legal Elite. The attorneys chosen by their peers for this ... of Florida. , Seven Greenberg Traurig Shareholders received special honors as members of this ...
(Date:6/24/2016)... ... ... People across the U.S. are sharpening their pencils and honing their writing skills ... patients and their families pay tribute to a genetic counselor by nominating him or ... Counselors (NSGC) Annual Education Conference (AEC) this September. , In April, Genome magazine ...
(Date:6/24/2016)... Frederick, Maryland (PRWEB) , ... June 24, 2016 ... ... Mid-Atlantic Angels is actively feeding the Frederick area economy by obtaining investment capital ... support over the past 2½ years that have already resulted in more than ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... 24, 2016 Research and Markets has ... Companion Diagnostic Tests" report to their offering. ... Diagnostics The World Market for Companion Diagnostics ... diagnostics. Market analysis in the report includes the following: ... Vitro Diagnostic Kits) by Region (N. America, EU, ROW), 2015-2020 ...
(Date:6/24/2016)... 2016  Arkis BioSciences, a leading innovator in ... durable cerebrospinal fluid treatments, today announced it has ... is led by Innova Memphis, followed by Angel ... investors.  Arkis, new financing will accelerate the commercialization ... release of its in-licensed Endexo® technology. ...
(Date:6/23/2016)... , June 23, 2016 ... "Pharmaceutical Excipients Market by Type (Organic Chemical (Sugar, ... Formulation (Oral, Topical, Coating, Parenteral) - Global Forecast to ... The global pharmaceutical excipients market ... at a CAGR of 6.1% in the forecast period ...
Breaking Medicine Technology: