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Mice with human body's defenses
Date:10/5/2010

ablo Becker, scientist in the HZI department "Vaccinology and Applied Microbiology".

To validate the new approach, mice with a human immune system were vaccinated against Hepatitis B or Tetanus. The scientists then isolated human antibody producing B cells from the mice and treated them so that they survive outside the body in a cell culture dish and continue producing antibodies. Then, the researchers took a deeper look at the antibodies. The results give hope: "Antibodies from mice with a human immune system showed good properties in our tests, but the model still needs to be improved for broad implementation in biomedicine," says Pablo Becker. "However, we were able to demonstrate for the first time that it is possible to produce human monoclonal antibodies using humanized mice." Now it is important to improve this mouse model to use it one day for the development of advanced therapies against human diseases. "In the future this approach might represent the most powerful tool to develop therapeutic antibodies for clinical use," hopes Becker.


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Contact: Dr. Bastian Dornbach
bastian.dornbach@helmholtz-hzi.de
49-531-618-11407
Helmholtz Association of German Research Centres
Source:Eurekalert

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