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Mice with human body's defenses
Date:10/5/2010

Therapeutic antibodies can be an efficient alternative when common drugs do not work anymore. However, antibodies obtained from blood of animals such as mice could not be used: The human immune system recognizes them as foreign and rejects them. In an international cooperation, scientists from the Helmholtz Centre for Infection Research (HZI) in Braunschweig, Germany have now succeeded in developing a promising approach to solve this problem; with the help of human stem cells they generated mice with a human immune system, which were then vaccinated to produce human monoclonal antibodies. These fully human antibodies could help in the research and therapy of human diseases. Their results have now been published in the current online issue of the scientific journal "PLoS One".

Antibodies are small proteins, produced by B cells during an immune response. They bind at and thus mark invading pathogens so that scavenger cells recognize and destroy them. "The task of our immune system is to distinguish between self and non-self structures," says Professor Carlos A. Guzmn, head of the department of "Vaccinology and Applied Microbiology" at the HZI. "This means also that only human antibodies come into question for an antibody therapy", since the human immune system fights antibodies from mice a threat for the patient. Furthermore, it is cumbersome to humanize murine antibodies for human treatment or to generate human B cell clones producing high quantities of antibodies.

The scientists used an already established method to give a human immune system to mice, which were then exploited to solve this problem: they injected human stem cells into young mice that due to a genetic defect lack an immune system. The stem cells migrate into the bone marrow, proliferate, differentiate and lead to the generation of a human immune system. "In our in-depth investigations we were able to detect all important types of immune cells in these mice," says Dr. P
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Contact: Dr. Bastian Dornbach
bastian.dornbach@helmholtz-hzi.de
49-531-618-11407
Helmholtz Association of German Research Centres
Source:Eurekalert

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