Navigation Links
Mice with human body's defenses
Date:10/5/2010

Therapeutic antibodies can be an efficient alternative when common drugs do not work anymore. However, antibodies obtained from blood of animals such as mice could not be used: The human immune system recognizes them as foreign and rejects them. In an international cooperation, scientists from the Helmholtz Centre for Infection Research (HZI) in Braunschweig, Germany have now succeeded in developing a promising approach to solve this problem; with the help of human stem cells they generated mice with a human immune system, which were then vaccinated to produce human monoclonal antibodies. These fully human antibodies could help in the research and therapy of human diseases. Their results have now been published in the current online issue of the scientific journal "PLoS One".

Antibodies are small proteins, produced by B cells during an immune response. They bind at and thus mark invading pathogens so that scavenger cells recognize and destroy them. "The task of our immune system is to distinguish between self and non-self structures," says Professor Carlos A. Guzmn, head of the department of "Vaccinology and Applied Microbiology" at the HZI. "This means also that only human antibodies come into question for an antibody therapy", since the human immune system fights antibodies from mice a threat for the patient. Furthermore, it is cumbersome to humanize murine antibodies for human treatment or to generate human B cell clones producing high quantities of antibodies.

The scientists used an already established method to give a human immune system to mice, which were then exploited to solve this problem: they injected human stem cells into young mice that due to a genetic defect lack an immune system. The stem cells migrate into the bone marrow, proliferate, differentiate and lead to the generation of a human immune system. "In our in-depth investigations we were able to detect all important types of immune cells in these mice," says Dr. P
'/>"/>

Contact: Dr. Bastian Dornbach
bastian.dornbach@helmholtz-hzi.de
49-531-618-11407
Helmholtz Association of German Research Centres
Source:Eurekalert

Page: 1 2

Related medicine news :

1. NIH scientists describe how salmonella bacteria spread in humans
2. New research technology to target human gut bacteria
3. Welsh scientists clone human virus
4. Scientists find link in humans between nerve cell production, memory
5. Human neural stem cells restore motor function in mice with chronic spinal cord injury
6. Input-output trade-offs found in human information processing
7. Human Meds Are Pets Biggest Poisoning Danger
8. NIH launches effort to define markers of human immune responses
9. New human adenovirus may not make for good vaccines, after all
10. Human clinical trial of NIH-developed dengue vaccine begins
11. Human embryonic stem cells purified in new, rapid technique
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/12/2014)... 2014 A recent article released by Seattle's ... of suggestions for those seeking cosmetic surgical procedures in ... approaching and the heat begins to enliven the rainy Pacific ... clothing, realizing that they didn’t work out as much during ... cause a sudden surge of people eager to look their ...
(Date:7/12/2014)... FL (PRWEB) July 12, 2014 Maxim ... high-quality peptides that are used solely in scientific experiments, ... two successful years in business, Maxim Peptide, which was ... just launched a new and updated website that now ... blog section has been updated with fascinating articles about ...
(Date:7/11/2014)... Va. (PRWEB) July 11, 2014 The ... at America’s 55 poison centers are commending Senator Bill ... Poison Prevention Act of 2014 on July 10, 2014. ... U.S. Consumer Products Safety Commission (CPSC) to enact rules ... to consumers. , Senate co-sponsors of the ...
(Date:7/11/2014)... Reducing the number of deer in an area can ... tick-borne infections among people, new research indicates. "Our ... reduce human interactions with deer, infected nymphal ticks and ... White-tailed deer are the primary host for adult ... The study included nearly all the permanent residents of ...
(Date:7/11/2014)... York, NY (PRWEB) July 11, 2014 ... http://www.gynecaremorcellatorlawsuit.com/ ) investigation, Bernstein Liebhard LLP has been ... Food & Drug Administration’s (FDA) Obstetrics and ... explore ways to mitigate the cancer risks associated ... invasive gynecological surgeries. According to a report published ...
Breaking Medicine News(10 mins):Health News:Best Summer Cosmetic Surgeries Revealed in Article By Seattle Plastic Surgeon 2Health News:Maxim Peptide Celebrates Second Anniversary Online with an Updated Website and Special Deals Section 2Health News:AAPCC Issues Statement on the Introduction of the Child Nicotine Poison Prevention Act of 2014 2Health News:AAPCC Issues Statement on the Introduction of the Child Nicotine Poison Prevention Act of 2014 3Health News:Morcellator Lawsuit News: Bernstein Liebhard LLP Notes Financial Ties Between FDA Advisory Panel Members and Manufacturers of Power Morcellators 2Health News:Morcellator Lawsuit News: Bernstein Liebhard LLP Notes Financial Ties Between FDA Advisory Panel Members and Manufacturers of Power Morcellators 3Health News:Morcellator Lawsuit News: Bernstein Liebhard LLP Notes Financial Ties Between FDA Advisory Panel Members and Manufacturers of Power Morcellators 4
... Day of Fall, September 22, Focuses on Preventing ... Today Congress issued,another call to action urging government, ... prevent the increasing number of falls,among people 65 ... (D-MD),and Mike Enzi (R-WY), as well as Representatives ...
... the 2006 Medicare Current Beneficiary Survey, WASHINGTON, ... option for low and moderate income seniors and ... data from the Medicare,Current Beneficiary Survey (MCBS)., ... and those,living in rural areas, rely on Medigap ...
... Olympic Games Champion Nikki Stone and Chronic Pain ... 22 The American Society of Pain,Educators (ASPE) ... Is Your Persistent Chronic Pain Weighing You Down? ... of proper,weight control in managing chronic pain., ...
... therapy delivered in only a week , , MONDAY, Sept. ... radiosurgery may be a viable treatment for recurring pancreatic ... Center, using their precise CyberKnife to perform radiosurgery, had ... the date of treatment. The range of survival was ...
... babies. , Now, it appears how infants respond to stress ... certain gene, according to a new study from the University of ... say they have also found that good parenting as early ... counter the effect the gene has in babies who initially do ...
... Enables SPECT Procedures ... New ASNC Technology Standards, POWAY, Calif., Sept. 22 ... imaging systems and,services to physicians, offices, hospitals and other medical ... Drug,Administration (FDA) 510(k) clearance for its new nSPEED(R) reconstruction,software -- ...
Cached Medicine News:Health News:Home Safety Council(R) Applauds Creation of Falls Prevention Awareness Day 2Health News:New Webcast Going for Gold to Educate on Importance of Healthy Diet In Persistent Chronic Pain Management 2Health News:New Webcast Going for Gold to Educate on Importance of Healthy Diet In Persistent Chronic Pain Management 3Health News:New Webcast Going for Gold to Educate on Importance of Healthy Diet In Persistent Chronic Pain Management 4Health News:New Webcast Going for Gold to Educate on Importance of Healthy Diet In Persistent Chronic Pain Management 5Health News:Radiosurgery Proves Viable for Some Pancreatic Cancers 2Health News:UNC study: Parenting can override effect of genes in how babies respond to stress 2Health News:Digirad Corporation Receives FDA 510(k) Clearance for nSPEED(R) Reconstruction Software for Improved Image Quality in Less Time With Less Radiation 2Health News:Digirad Corporation Receives FDA 510(k) Clearance for nSPEED(R) Reconstruction Software for Improved Image Quality in Less Time With Less Radiation 3
(Date:7/11/2014)... -- Research and Markets ( http://www.researchandmarkets.com/research/tjlw9k/immunoprotein ) has ... Testing Market - Forecasts to 2019: Expected to ... is expected to be valued at USD 4,943.0 ... http://photos.prnewswire.com/prnh/20130307/600769 The ... according to immunoprotein types which include immunoglobulins, complement ...
(Date:7/10/2014)... , 11. Juli 2014  Dilon ... für die molekulare Bildgebung, einschließlich molekularer ... die CE-Zulassung für sein Navigator ® ... Dilon das Produkt jetzt europaweit vertreiben. ... Großteil der europäischen Länder ausgedehnt und ...
(Date:7/10/2014)... 10, 2014 Yesterday, former Congressman ... device manufacturing facility. Rep. Kennedy and Dick ... facilitate cutting-edge research in neurological disease and treatment. ... health advocate, Garen Staglin , created One ... fundamental changes that will radically accelerate the development ...
Breaking Medicine Technology:Immunoprotein Diagnostic Testing Market - Forecasts to 2019: Expected to grow at the highest CAGR of 6% and is expected to be valued at USD 4,943.0 million 2Dilon erhält CE-Zulassung für sein Navigator-Gamma-Sondensystem 2Representative Patrick Kennedy visits Moberg's medical device facility to discuss improvement in brain injury care 2
... Reportlinker.com announces that a new market ... Respiratory Devices - Global ... to 2016 http://www.reportlinker.com/p0240243/Respiratory-Devices---Global-Pipeline-Analysis-Opportunity-Assessment-and-Market-Forecasts-to-2016.html ... Global Pipeline Analysis, Opportunity Assessment and Market ...
... 14 AAIPharma Services Corp., a leading provider of ... announced today that it has appointed Patrick D. Walsh ... equity firm focused exclusively on health care that acquired ... company in 2009, was instrumental in recruiting Mr. Walsh ...
Cached Medicine Technology:Reportlinker Adds Respiratory Devices - Global Pipeline Analysis, Opportunity Assessment and Market Forecasts to 2016 2Reportlinker Adds Respiratory Devices - Global Pipeline Analysis, Opportunity Assessment and Market Forecasts to 2016 3AAIPharma Services Corp. Names Patrick Walsh Chief Executive Officer 2AAIPharma Services Corp. Names Patrick Walsh Chief Executive Officer 3
... for vascular treatments, Smart VS is the most ... fast amortisation of the investment made. Like all ... with a polarised light viewing system for ensuing ... as well as the operators maximum comfort. I ...
... is an exceptional condensate of ... dimensions for ensuring a rational ... constantly evolving professional market. PhotoLight ... in different studios who require ...
... 2000 system is a pulsed DYE laser ... specific pathologies like Port Wine Stains (PWS), ... pathologies of the trunk and the face. ... all these pathologies, the DYE laser naturally ...
... Plus is a CO2 laser system ... W. Its functions in continuous and ... requiring extreme laser intervention delicacy. Excellent ... studios, it comes with a large ...
Medicine Products: