Navigation Links
Mice Exposed to Smoke Helped by Blood Pressure Drug: Study
Date:1/6/2012

FRIDAY, Jan. 6 (HealthDay News) -- The blood pressure medicine losartan [Cozaar] helped prevent lung damage in mice that were exposed to cigarette smoke for two months, researchers say.

Specifically, the drug prevented lung tissue breakdown, airway wall thickening, inflammation and lung overexpansion in the animals, according to the Johns Hopkins researchers.

The findings have led to a clinical trial of losartan in people with smoking-related chronic obstructive pulmonary disease (COPD). About 12 million Americans have COPD, which is the third leading cause of death in the United States.

The study, published in the Jan. 3 issue of the Journal of Clinical Investigation, was funded by drugmaker Merck & Co. and the U.S. National Heart, Lung and Blood Institute.

"The results of our study in mice suggest that losartan or similar drugs could serve as an effective treatment for smoking-related lung diseases in humans," senior investigator Dr. Enid Neptune, a pulmonologist and assistant professor at the Johns Hopkins University School of Medicine, said in a Hopkins news release.

"And because these drugs are already approved for use in the United States as safe and effective treatments for hypertension, incorporating them into our treatment regimen for COPD would be quite rapid," Neptune added.

"It is very exciting that an existing medication has proven capable in an animal model of not only treating the problems of COPD, but also disrupting the biological pathway that precipitated them," pulmonologist Dr. Robert A. Wise, a Johns Hopkins professor who is leading the human clinical studies, said in the news release.

"If our tests in people prove successful, we could help restore lung health to millions of people who have suffered from tobacco addiction," Wise added.

Existing therapies for smoking-related COPD mainly provide relief of symptoms, such as shortness of breath, coughing and mucus production, Wise said. Blood pressure-lowering drugs may also help and some patients have surgery to remove damaged sections of the lung or undergo lung transplants.

While the findings of the new study are promising, scientists note that research involving animals often fails to produce similar results in humans.

More information

The American Academy of Family Physicians has more about chronic obstructive pulmonary disease.

-- Robert Preidt

SOURCE: Johns Hopkins Medicine, news release, Jan. 3, 2012


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. WTC workers exposed earlier to dust cloud have higher risk of atherosclerotic lesions
2. Parkinsons disease risk greater in those exposed to trichloroethylene
3. Women exposed to diethylstilbestrol in the womb face increased cancer risk
4. Health Woes Still Strike Women Exposed to Banned Pregnancy Drug
5. Preterm infants exposed to stressors in NICU display reduced brain size
6. World Trade Center-exposed NYC firefighters face increased cancer risk
7. 17 percent of cancer nurses unintentionally exposed to chemotherapy, U-M study finds
8. Women Exposed to Combat Trauma as Resilient as Men: Study
9. High risk of Parkinsons disease for people exposed to pesticides near workplace
10. Adalimumab levels detected in cord blood and infants exposed in utero
11. Pet Dogs May Be Exposed to High Levels of Flame Retardants
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Mice Exposed to Smoke Helped by Blood Pressure Drug: Study
(Date:8/20/2017)... ... August 20, 2017 , ... Are you an adult with gluten intolerance ... you may be interested in participating in a research study that focuses on family ... understand more about the relational aspects of adults who have gluten sensitivities who cohabitate ...
(Date:8/19/2017)... (PRWEB) , ... August 18, 2017 , ... ... Drug Administration Reauthorization Act of 2017, legislation that provides for greater public access ... to moderate hearing loss to access OTC hearing aids without being seen by ...
(Date:8/19/2017)... ... August 19, 2017 , ... Yesterday, the President of the United States ... two sides. There are not two sides to hatred, bigotry, discrimination, and a white ... and the NPEIV stands against all forms of such hatred and discrimination in this ...
(Date:8/18/2017)... , ... August 19, 2017 , ... ... Authority of Thailand presided over the Amazing Thailand Health and Wellness Tourism Showcase ... , Mr. Noppadon Pakprot, Deputy Governor for Tourism Products and Business at TAT ...
(Date:8/18/2017)... ... August 18, 2017 , ... ... campaign, advocating for active, healthy lifestyles and highlighting the importance of proactive eye ... hearing impairments and shares the latest innovations in hearing aid technology. , ...
Breaking Medicine News(10 mins):
(Date:8/15/2017)... Aug. 15, 2017 AccuGenomics, Inc., a diagnostic ... today announced that the company has provided an AccuKit ... North Carolina at Chapel Hill and to Qura Therapeutics ... characterize and quantify HIV reservoir and viral expression in ... The HIV Cure Center is a joint initiative between ...
(Date:8/14/2017)... TIKVAH, Israel , Aug. 15, 2017 ... developer of adult stem cell technologies for neurodegenerative diseases, ... 30, 2017. "We ... pivotal Phase 3 trial to investigate NurOwn ® ... Chief Executive Officer of BrainStorm. "We have agreements with ...
(Date:8/10/2017)... -- Physical Rehabilitation Network (PRN), acquired the long-standing outpatient rehabilitation clinic, ... . The reputable clinic will continue to be co-owned and ... staff of four clinicians. Lipkin received his doctorate in physical ... years of experience with a strong background in manual therapy. ... 10th PRN clinic in and around the Denver ...
Breaking Medicine Technology: