Navigation Links
Mice Can Sense Oxygen Through Their Skin

Finding hints of new treatments for anemia, other diseases that affect red blood cells

THURSDAY, April 17 (HealthDay News) -- Mice can sense oxygen through their skin, says a new study that showed the skin plays a major role in sensing oxygen levels in the environment and in stimulating kidney production of the hormone erythropoietin (EPO) when oxygen levels decline.

EPO boosts production of red blood cells that carry and deliver oxygen throughout the body. If this finding is replicated in humans, it could lead to new ways to treat anemia and other diseases that affect red blood cell counts. It may also prove important for endurance athletes, who sometimes train at high altitudes or in low-oxygen tents to increase EPO and red blood cell levels, said Randall Johnson, of the University of California, San Diego.

It's long been known that amphibians can breathe in part through their skin, but the finding that skin plays a role in oxygen sensing in mammals was a surprise, Johnson said. This suggests that oxygen-sensing in skin is an ancient feature and was retained during the evolution of mammals.

"As it turns out, when we looked for the ion channels involved in this process in frog skin -- which are also present in mammalian lungs -- we found the same channels present in the skin of a mouse. No one had ever looked," Johnson said in a prepared statement.

In their tests with mice, Johnson and his colleagues showed that the underlying physiology of the oxygen sensing response in the skin of mice includes an increase of blood flow to the skin. They also found that applying nitroglycerin to the skin of the mice boosted EPO and red blood cells levels.

The study was published in the April 18 issue of Cell.

"EPO administration is a multi-billion dollar drug market for the treatment of all sorts of diseases involving low red blood cell counts," Johnson said. "The ability to manipulate red blood cell production just by changing blood flow through certain parts of the skin could be profound. We show in this study that, by just placing a little nitroglycerin patch, we were able to trigger very big increases in EPO. Whether this will turn out to be true for humans, we don't know yet."

More information

The U.S. National Heart, Lung, and Blood Institute has more about anemia.

-- Robert Preidt

SOURCE: Cell Press, news release, April 17, 2008

Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Poor Sense of Smell May Be Early Sign of Parkinsons
2. Antisense therapeutics scientist out to pull more big deals
3. Impaired sense of smell may be early indicator of Parkinsons disease
4. New Scenic Relaxation Videos Help Reduce Stress, Promote Sense of Calm and Tranquility
5. Sense of personal control influences Latinas decisions about sexual debut
6. URAC Names Sensei for Weight Loss as a Finalist in First-Ever Best Practices in Consumer Empowerment and Protection Awards
7. Isis and Excaliard Collaborate to Develop Antisense Drugs for Local Treatment of Fibrotic Diseases
8. How do we make sense of what we see?
9. Bayer Awards Making Science Make Sense Grant to Girl Scouts
10. Redsense Medical Receives FDA Approval for Blood Loss Detection Device
11. Ex-Head of Menarini Diabetes Unit Launches WaveSense Europe
Post Your Comments:
(Date:11/27/2015)... ... November 27, 2015 , ... ProSidebar: Fashion ... Cut Pro X. With ProSidebar: Fasion, video editors can easily add an informative ... a minimalist title opener. Utilize presets featuring self-animating drop zones, lines, bars, and ...
(Date:11/27/2015)... ... November 27, 2015 , ... Consistent with the ... 2016 Building Better Radiology Marketing Programs meeting will showcase some of ... 6, 2016, at Caesars Palace in Las Vegas with a pre-conference session on ...
(Date:11/27/2015)... ... ... A simply groundbreaking television series, "Voices in America", which is hosted by Hollywood ... issues that are presently affecting Americans. Dedicated to providing the world with a wide ... subjects consumers focus on, one episode at a time. , In the latest ...
(Date:11/27/2015)... ... November 27, 2015 , ... Keeping ... platform for mental health and wellness consultation, has collaborated with a leading web-based ... the knowledge gap experienced by parents and bring advice from parenting experts within ...
(Date:11/27/2015)... ... 2015 , ... The men and women on this list ... the country. They have overseen financial turnarounds, shown commitment to their community through ... as a whole through their advocacy and professional efforts. , Becker's Hospital Review ...
Breaking Medicine News(10 mins):
(Date:11/26/2015)... , November 26, 2015 ... the addition of the  "2016 Future ... European Therapeutic Drug Monitoring (TDM) Market: ... Intelligence, Emerging Opportunities"  report to their ... has announced the addition of the  ...
(Date:11/26/2015)... , November 26, 2015 ... the "Self Administration of High Viscosity Drugs" ... ) has announced the addition of the ... report to their offering. --> Research ... addition of the "Self Administration of High ...
(Date:11/26/2015)... DUBLIN , November 26, 2015 /PRNewswire/ ... the addition of the "Radioimmunoassay Market ... User (Hospital, Pharmaceutical Industry, Academics, Clinical Diagnostic ... - Global Forecast to 2020" report ... ) has announced the addition of the ...
Breaking Medicine Technology: