Navigation Links
Mice Can Sense Oxygen Through Their Skin
Date:4/17/2008

Finding hints of new treatments for anemia, other diseases that affect red blood cells

THURSDAY, April 17 (HealthDay News) -- Mice can sense oxygen through their skin, says a new study that showed the skin plays a major role in sensing oxygen levels in the environment and in stimulating kidney production of the hormone erythropoietin (EPO) when oxygen levels decline.

EPO boosts production of red blood cells that carry and deliver oxygen throughout the body. If this finding is replicated in humans, it could lead to new ways to treat anemia and other diseases that affect red blood cell counts. It may also prove important for endurance athletes, who sometimes train at high altitudes or in low-oxygen tents to increase EPO and red blood cell levels, said Randall Johnson, of the University of California, San Diego.

It's long been known that amphibians can breathe in part through their skin, but the finding that skin plays a role in oxygen sensing in mammals was a surprise, Johnson said. This suggests that oxygen-sensing in skin is an ancient feature and was retained during the evolution of mammals.

"As it turns out, when we looked for the ion channels involved in this process in frog skin -- which are also present in mammalian lungs -- we found the same channels present in the skin of a mouse. No one had ever looked," Johnson said in a prepared statement.

In their tests with mice, Johnson and his colleagues showed that the underlying physiology of the oxygen sensing response in the skin of mice includes an increase of blood flow to the skin. They also found that applying nitroglycerin to the skin of the mice boosted EPO and red blood cells levels.

The study was published in the April 18 issue of Cell.

"EPO administration is a multi-billion dollar drug market for the treatment of all sorts of diseases involving low red blood cell counts," Johnson said. "The ability to manipulate red blood cell production just by changing blood flow through certain parts of the skin could be profound. We show in this study that, by just placing a little nitroglycerin patch, we were able to trigger very big increases in EPO. Whether this will turn out to be true for humans, we don't know yet."

More information

The U.S. National Heart, Lung, and Blood Institute has more about anemia.



-- Robert Preidt



SOURCE: Cell Press, news release, April 17, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Poor Sense of Smell May Be Early Sign of Parkinsons
2. Antisense therapeutics scientist out to pull more big deals
3. Impaired sense of smell may be early indicator of Parkinsons disease
4. New Scenic Relaxation Videos Help Reduce Stress, Promote Sense of Calm and Tranquility
5. Sense of personal control influences Latinas decisions about sexual debut
6. URAC Names Sensei for Weight Loss as a Finalist in First-Ever Best Practices in Consumer Empowerment and Protection Awards
7. Isis and Excaliard Collaborate to Develop Antisense Drugs for Local Treatment of Fibrotic Diseases
8. How do we make sense of what we see?
9. Bayer Awards Making Science Make Sense Grant to Girl Scouts
10. Redsense Medical Receives FDA Approval for Blood Loss Detection Device
11. Ex-Head of Menarini Diabetes Unit Launches WaveSense Europe
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... PurhealthRX ... CBD Oil utilizing Purzorb™ technology. Applying the Purzorb™process to full spectrum CBD oil will ... and providing a CBD form that can be easily incorporated into liquid products, while ...
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... Many families ... However, many long-term care insurance companies have a waiver for care if the client ... elimination period, when the family pays for care, is often waived, so the benefits ...
(Date:10/13/2017)... , ... October 13, 2017 , ... Yisrayl Hawkins, Pastor ... that explains one of the most popular and least understood books in the Holy ... and puzzling descriptions that have baffled scholars for centuries. Many have tossed it off ...
(Date:10/13/2017)... ... ... “America On The Brink”: the Christian history of the United States and the loss ... author, William Nowers. Captain Nowers and his wife, Millie, have six children, ten ... the Navy. Following his career as a naval aviator and carrier pilot, he ...
(Date:10/12/2017)... ... October 12, 2017 , ... The company has developed ... consumer and regulatory authorities worldwide. From Children’s to Adults 50+, every formula has ... highest standard. , These products are also: Gluten Free, Non-GMO, Vegan, Soy ...
Breaking Medicine News(10 mins):
(Date:9/28/2017)... Hill-Rom Holdings, Inc. (NYSE: HRC), will host ... webcast on Friday, November 3, 2017, beginning at 7:00 ... approximately 8:30 a.m. (CDT) / 9:30 a.m. (EDT). ... performance and guidance for 2018, Hill-Rom executives will also ... performance, and long-range financial outlook through 2020. ...
(Date:9/25/2017)... --  Montrium , an industry leader in powerful ... Trial Master Files & Inspection Readiness Conference ( ... Services has selected eTMF Connect to ... a leading European contract research organization (CRO), will ... enable greater collaboration with sponsors, improve compliance and ...
(Date:9/22/2017)... -- AVACEN Medical (AVACEN) announced that its CE-Marked AVACEN ... with the widespread pain associated with fibromyalgia in the ... Essex, England commented, "I had difficulty ... sleep at all, tremendous pain, with every movement sending ... AVACEN 100] enough, how this has and is helping ...
Breaking Medicine Technology: