Navigation Links
Mice Can Sense Oxygen Through Their Skin
Date:4/17/2008

Finding hints of new treatments for anemia, other diseases that affect red blood cells

THURSDAY, April 17 (HealthDay News) -- Mice can sense oxygen through their skin, says a new study that showed the skin plays a major role in sensing oxygen levels in the environment and in stimulating kidney production of the hormone erythropoietin (EPO) when oxygen levels decline.

EPO boosts production of red blood cells that carry and deliver oxygen throughout the body. If this finding is replicated in humans, it could lead to new ways to treat anemia and other diseases that affect red blood cell counts. It may also prove important for endurance athletes, who sometimes train at high altitudes or in low-oxygen tents to increase EPO and red blood cell levels, said Randall Johnson, of the University of California, San Diego.

It's long been known that amphibians can breathe in part through their skin, but the finding that skin plays a role in oxygen sensing in mammals was a surprise, Johnson said. This suggests that oxygen-sensing in skin is an ancient feature and was retained during the evolution of mammals.

"As it turns out, when we looked for the ion channels involved in this process in frog skin -- which are also present in mammalian lungs -- we found the same channels present in the skin of a mouse. No one had ever looked," Johnson said in a prepared statement.

In their tests with mice, Johnson and his colleagues showed that the underlying physiology of the oxygen sensing response in the skin of mice includes an increase of blood flow to the skin. They also found that applying nitroglycerin to the skin of the mice boosted EPO and red blood cells levels.

The study was published in the April 18 issue of Cell.

"EPO administration is a multi-billion dollar drug market for the treatment of all sorts of diseases involving low red blood cell counts," Johnson said. "The ability to manipulate red blood cell production just by changing blood flow through certain parts of the skin could be profound. We show in this study that, by just placing a little nitroglycerin patch, we were able to trigger very big increases in EPO. Whether this will turn out to be true for humans, we don't know yet."

More information

The U.S. National Heart, Lung, and Blood Institute has more about anemia.



-- Robert Preidt



SOURCE: Cell Press, news release, April 17, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Poor Sense of Smell May Be Early Sign of Parkinsons
2. Antisense therapeutics scientist out to pull more big deals
3. Impaired sense of smell may be early indicator of Parkinsons disease
4. New Scenic Relaxation Videos Help Reduce Stress, Promote Sense of Calm and Tranquility
5. Sense of personal control influences Latinas decisions about sexual debut
6. URAC Names Sensei for Weight Loss as a Finalist in First-Ever Best Practices in Consumer Empowerment and Protection Awards
7. Isis and Excaliard Collaborate to Develop Antisense Drugs for Local Treatment of Fibrotic Diseases
8. How do we make sense of what we see?
9. Bayer Awards Making Science Make Sense Grant to Girl Scouts
10. Redsense Medical Receives FDA Approval for Blood Loss Detection Device
11. Ex-Head of Menarini Diabetes Unit Launches WaveSense Europe
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/6/2016)... ... ... From May 4 to 6, EarQ and Signia co-sponsored a ... more about Signia’s technology and the successful business and marketing techniques that make EarQ ... practices succeed in this highly competitive industry,” said Ed Keller, president of EarQ. “This ...
(Date:5/6/2016)... Diego, CA (PRWEB) , ... May 06, 2016 , ... ... Companies, has been family-owned and operated for over 35 years. Maintaining core values of ... has driven their success and made them a leading name in San Diego plumbing, ...
(Date:5/6/2016)... (PRWEB) , ... May 06, 2016 , ... ... System and David Konur, CEO of Cardiovascular Institute of the South announced today ... be performing a live case of an Intravascular Ultrasound Guided Coronary Atherectomy. ...
(Date:5/5/2016)... ... May 05, 2016 , ... Pivot Point Consulting ... gold standard KLAS Performance Report, Epic Consulting 2016 - Which Firms ... specialize in consulting services for electronic health record (EHR) solutions from Epic ...
(Date:5/5/2016)... Tampa, FL (PRWEB) , ... May 05, 2016 ... ... hospital in Tampa to offer patients with non-valvular atrial fibrillation (A-Fib) an alternative ... (LAAC) Implant. Since first offering the procedure in April of 2015, Florida Hospital ...
Breaking Medicine News(10 mins):
(Date:5/4/2016)... 4, 2016 Research ... "Global Acute Myeloid Leukemia Market and Competitive ... offering.       (Logo: http://photos.prnewswire.com/prnh/20160330/349511LOGO ... Market and Competitive Landscape Highlights 2016, provides ... products, Acute Myeloid Leukemia epidemiology, Acute Myeloid ...
(Date:5/3/2016)... Global Insulin Needles Industry ... key companies and supported with 272 tables and ... on the current state of the Insulin Needles ... including definitions, classifications, applications and industry chain structure. ... the international market including development history, competitive landscape ...
(Date:5/3/2016)... May 3, 2016  Axiogenesis has acquired a major investment from Sino-German High-Tech Fund to further expand product development, ... - http://photos.prnewswire.com/prnh/20160503/362921 ... ... ... ...
Breaking Medicine Technology: