Navigation Links
Mice Can Sense Oxygen Through Their Skin
Date:4/17/2008

Finding hints of new treatments for anemia, other diseases that affect red blood cells

THURSDAY, April 17 (HealthDay News) -- Mice can sense oxygen through their skin, says a new study that showed the skin plays a major role in sensing oxygen levels in the environment and in stimulating kidney production of the hormone erythropoietin (EPO) when oxygen levels decline.

EPO boosts production of red blood cells that carry and deliver oxygen throughout the body. If this finding is replicated in humans, it could lead to new ways to treat anemia and other diseases that affect red blood cell counts. It may also prove important for endurance athletes, who sometimes train at high altitudes or in low-oxygen tents to increase EPO and red blood cell levels, said Randall Johnson, of the University of California, San Diego.

It's long been known that amphibians can breathe in part through their skin, but the finding that skin plays a role in oxygen sensing in mammals was a surprise, Johnson said. This suggests that oxygen-sensing in skin is an ancient feature and was retained during the evolution of mammals.

"As it turns out, when we looked for the ion channels involved in this process in frog skin -- which are also present in mammalian lungs -- we found the same channels present in the skin of a mouse. No one had ever looked," Johnson said in a prepared statement.

In their tests with mice, Johnson and his colleagues showed that the underlying physiology of the oxygen sensing response in the skin of mice includes an increase of blood flow to the skin. They also found that applying nitroglycerin to the skin of the mice boosted EPO and red blood cells levels.

The study was published in the April 18 issue of Cell.

"EPO administration is a multi-billion dollar drug market for the treatment of all sorts of diseases involving low red blood cell counts," Johnson said. "The ability to manipulate red blood cell production just by changing blood flow through certain parts of the skin could be profound. We show in this study that, by just placing a little nitroglycerin patch, we were able to trigger very big increases in EPO. Whether this will turn out to be true for humans, we don't know yet."

More information

The U.S. National Heart, Lung, and Blood Institute has more about anemia.



-- Robert Preidt



SOURCE: Cell Press, news release, April 17, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Poor Sense of Smell May Be Early Sign of Parkinsons
2. Antisense therapeutics scientist out to pull more big deals
3. Impaired sense of smell may be early indicator of Parkinsons disease
4. New Scenic Relaxation Videos Help Reduce Stress, Promote Sense of Calm and Tranquility
5. Sense of personal control influences Latinas decisions about sexual debut
6. URAC Names Sensei for Weight Loss as a Finalist in First-Ever Best Practices in Consumer Empowerment and Protection Awards
7. Isis and Excaliard Collaborate to Develop Antisense Drugs for Local Treatment of Fibrotic Diseases
8. How do we make sense of what we see?
9. Bayer Awards Making Science Make Sense Grant to Girl Scouts
10. Redsense Medical Receives FDA Approval for Blood Loss Detection Device
11. Ex-Head of Menarini Diabetes Unit Launches WaveSense Europe
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... ... June 25, 2016 , ... As a lifelong Southern ... Laude and his M.D from the David Geffen School of Medicine at UCLA. He ... Los Angeles to complete his fellowship in hematology/oncology at the UCLA-Olive View-Cedars Sinai program ...
(Date:6/25/2016)... (PRWEB) , ... June 25, 2016 , ... On Friday, ... presented a Bronze Wellness at Work award to iHire in recognition of their exemplary ... part of the 7th annual Maryland Workplace Health & Wellness Symposium at the BWI ...
(Date:6/24/2016)... ... June 24, 2016 , ... A recent article ... are unfamiliar with. The article goes on to state that individuals are now more ... these less common operations such as calf and cheek reduction. The Los Angeles area ...
(Date:6/24/2016)... ... June 24, 2016 , ... June 19, 2016 is World ... with chronic pain and the benefits of holistic treatments, Serenity Recovery Center ... with Sickle Cell Disease. , Sickle Cell Disease (SCD) is a disorder of the ...
(Date:6/24/2016)... Dallas, Texas (PRWEB) , ... June 24, 2016 ... ... 12th International Conference and Scientific Sessions in Dallas that it will receive two ... Announcement of the grants came as PHA marked its 25th anniversary by recognizing ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... INDIANAPOLIS , June 23, 2016 /PRNewswire/ ... Diabetes Tomorrow,s Leaders Scholarship is any indication, the future ... today online at www.diabetesscholars.org by the Diabetes ... stand in the way of academic and community service ... scholarship program since 2012, and continues to advocate for ...
(Date:6/23/2016)... N.J. , June 23, 2016  Guerbet announced ... Premier Inc.,s Supplier Horizon Award . ... year, Guerbet was recognized for its support of Premier ... creation through clinical excellence, and commitment to lower costs. ... to receive this recognition of our outstanding customer service ...
(Date:6/23/2016)... 2016  Experian Health, the healthcare industry ... patient payment and care experience, today announced ... and services that will enhance the breadth ... These award-winning solutions will enable healthcare professionals ... in an ever-changing environment and redefine front-office ...
Breaking Medicine Technology: