Navigation Links
MiRNA-21 linked to tumor suppressor loss, herceptin resistance
Date:4/19/2010

of Texas Graduate School of Biomedical Sciences at Houston (GSBS). "MiRNA regulation is disrupted in most diseases and in all cancers." Altered expression of miRNA also has been linked to the development of resistance to chemotherapy drugs such as cisplatin.

The researchers suspected that overexpression of miRNA-21 leads to reduced levels of PTEN and, in turn, to resistance to Herceptin. Herceptin is a targeted therapy used to treat metastatic breast cancer. Like other targeted cancer treatments, Herceptin homes in on a specific abnormal gene to slow or shut down cancer growth. The target gene in Herceptin treatment is ErbB-2-also known as HER2/neu or HER2.

"Herceptin is the most successful example of targeted cancer therapy," Yu noted. "But only about one-third of patients benefit from this therapy as a single agent." PTEN loss is a key reason.

MiRNA-21's role in Herceptin resistance

The hypothesis was tested in three HER2-overexpressing breast cancer cell lines. In a series of experiments, miRNA-21 and/or a control miRNA were introduced and expressed in the HER2-overexpressing cell lines. The cells were then treated with Herceptin. The researchers found that cells with higher levels of miRNA-21 had reduced PTEN expression and were significantly more resistant to the drug than were the control cells.

The researchers also determined that miRNA-21 reduces PTEN expression by inhibiting PTEN messenger RNA at a specific site in the PTEN transcript in breast cancer cells.

In another experiment, when the researchers downregulated miRNA-21 in high HER2-expressing cells, cellular PTEN levels rose, and the cells became more sensitive to Herceptin compared to control miRNA cells.

The researchers then sought to determine the clinical relevance of their findings by measuring levels of miRNA-21 in tumor samples from patients with HER2-positive breast cancer treated with Herceptin. They found a significant correlat
'/>"/>

Contact: Scott Merville
smerville@mdanderson.org
713-516-4855
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Abnormal Heart Rhythm Linked to Alzheimers
2. Human development index linked to stem cell transplant rates and success in leukemia patients
3. Temperature-sensing protein linked to skin cancer, hirsutism
4. Better patient safety linked to fewer medical malpractice claims in California
5. Age Management Medicine Conference Reports 21% Spike in Physician Registration, Linked To Frustrations With New Health Reform Legislation
6. Scientists find gene linked to schizophrenia
7. Vitamins C, E Wont Cut Risk of Pregnancy-Linked Hypertension
8. Fetal alcohol spectrum disorder linked to high prevalence of epilepsy, Queens study
9. Unvaccinated Boys at Risk of Mumps-Linked Testicular Problem
10. Parkinsons Linked to Genetic Mutation
11. Sleep Apnea Linked to Eyelid Disorder
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/22/2014)... Maureen Salamon HealthDay Reporter , ... in vitro fertilization (IVF) are only about half as likely ... reproduction technique, new research indicates, and the racial disparity persists ... about 31 percent of white patients became pregnant after IVF, ... more than 4,000 IVF cycles over two years to tease ...
(Date:10/22/2014)... Maureen Salamon HealthDay Reporter ... crucial part of conventional in vitro fertilization (IVF) -- the ... take place in a device inside the vagina, new research ... that the device, called an INVOcell, might sharply cut costs ... make the technology more accessible to those who don,t live ...
(Date:10/22/2014)... Thompson HealthDay Reporter TUESDAY, Oct. ... with Ebola while working for NBC News in Liberia ... special isolation unit at Nebraska Medical Center in Omaha, where he ... Tuesday. A blood test confirmed by the U.S. Centers for ... home to Providence, R.I., NBC News reported Tuesday night. ...
(Date:10/20/2014)... Allegheny General Hospital’s (AGH) Cardiovascular Institute ... to repair a damaged mitral valve as the heart ... developed by Abbott Vascular , is designed to ... condition in which the heart’s mitral valve leaflets fail ... the heart’s left ventricle into the left atrium. The ...
(Date:10/20/2014)... Women’s health specialist, Dr. Amber Murphy, MD, Ob/Gyn ... Inc., A Division of MaternOhio Clinical Associates, Inc., who ... patients annually. Dr. Murphy will provide a full range ... women’s life. She is accepting new patients at two ... , Dr. Murphy offers a wide variety of services ...
Breaking Medicine News(10 mins):Health News:Black Women Fare Worse With Fertility Treatments, Study Says 2Health News:Black Women Fare Worse With Fertility Treatments, Study Says 3Health News:Experimental Infertility Treatment Seems Effective, Cheaper 2Health News:Experimental Infertility Treatment Seems Effective, Cheaper 3Health News:Experimental Infertility Treatment Seems Effective, Cheaper 4Health News:U.S. Cameraman Treated for Ebola 'Free' of the Virus 2Health News:U.S. Cameraman Treated for Ebola 'Free' of the Virus 3Health News:Allegheny General Hospital Introduces New, Beating-Heart Procedure for Mitral Valve Repair 2Health News:Allegheny General Hospital Introduces New, Beating-Heart Procedure for Mitral Valve Repair 3Health News:OhioHealth Welcomes New Women’s Health Specialist to MaternOhio Specialists in Obstetrics & Gynecology of Columbus, Inc. 2Health News:OhioHealth Welcomes New Women’s Health Specialist to MaternOhio Specialists in Obstetrics & Gynecology of Columbus, Inc. 3
... feasibility of introducing health smart cards to ensure better ... of State for Health and Family Welfare Panabaka Lakshmi ... implementing the health smart cards," the minister told the ... pilot study was initiated in the capital in March ...
... Fund (UNFPA) Thoraya A Obaid said that Bangladesh has ... many challenges to address in the health sector to ... in population controlling, reducing child and maternal motility rate, ... education and primary healthcare services Bangladesh has showed remarkable ...
... of particles which are very small. They are submicroscopic ... // The petition was raised by environmental groups which ... its regulation of sunscreens that contain nano-sized titanium dioxide ... inflammatory and immune responses in the human body. These ...
... would rather give up a year of their life rather ... online survey conducted by the Rudd Center for Food Policy ... varying numbers between 15% and 30% also said they would ... of having children, be depressed, or become alcoholic rather than ...
... Cellular damage induced by oxygen free radicals may be ... new study. //This groundbreaking study conducted by neuroscientists at ... of complex I, a protein that plays a major ... has been blamed for cellular damage in Parkinson’s disease. ...
... ailment called economy class syndrome, that is associated with the ... due to cabin environment, //as it is thought to be, ... that clots could form in healthy people, while sitting in ... in the legs, which lead to the formation of clots. ...
Cached Medicine News:Health News:Government Considering Of Issuing ‘Smart Cards’ For HIV/AIDS Patien 2Health News:Bangladesh Progressing But Must Yet Face Challenges In Health Sector 2Health News:Fat People Claim That They Would Give Their Limb Or Life Rather Than Being Fat 2Health News:Oxygen-Induced Damage A Leading Cause For Parkinson’s Diseas 2
(Date:10/22/2014)... Oct. 21, 2014   BioNano Genomics , ... genomics research centers to purchase an Irys™ System ... National Cancer Institute (NCI), NIH Intramural Sequencing Center (NISC) ... Irys, obtaining a comprehensive view of a genome ... (NGS) does not deliver the scalability or reliability ...
(Date:10/22/2014)... 2014 InVivo Therapeutics Holdings Corp. (OTCQB: NVIV) ... revolutionizing spinal cord injury (SCI) treatment with their novel ... in tissue regrowth in the spinal cord area when ... FDA approved polymer, the scaffold ultimately breaks down to ... human body. NVIV has recently attracted significant investor attention ...
(Date:10/22/2014)... Calif. , Oct. 22, 2014  AcelRx ... announced that results from the  IAP310 study have ... Medicine (RAPM), a peer-reviewed journal with broad, ... 3 trial evaluating the safety and efficacy of ... tablet system (SSTS), for the treatment of post-operative ...
Breaking Medicine Technology:BioNano's Irys System Adopted by Leading Genomics Centers for Comprehensive Detection of Human Genome Structural Variation 2BioNano's Irys System Adopted by Leading Genomics Centers for Comprehensive Detection of Human Genome Structural Variation 3InVivo Therapeutics Analyst Coverage Initiated: Analyst Report by BrokerBank Securities, Inc. 2InVivo Therapeutics Analyst Coverage Initiated: Analyst Report by BrokerBank Securities, Inc. 3AcelRx Announces Publication of Zalviso Phase 3 Abdominal Trial Results 2
Hudson Drill hand drill....
Hudson Brace, snap lock chuck....
Binocular operation microscope with innovative mechanism for smooth operation....
... has pioneered the development of ... system, an innovative solution that ... efficient and less invasive. The ... the OME-7000 surgical microscope, the ...
Medicine Products: