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MiP Consortium awarded €11 million by EDCTP
Date:5/8/2009

pread use, uncertainties about the optimal dose remain. This project will allow us to explore whether pregnant women need a different dose to non-pregnant women because of changes in the way the drug is assimilated during pregnancy. The results of this research will be used to inform WHO policy recommendations on the use of SP."

The Barcelona Center for International Health Research (CRESIB) has been awarded 3.6 million to undertake research to evaluate different drug alternatives, mefloquine (or MQ) and SP, for use as IPTp in the context of insecticide treated nets to prevent malaria in pregnancy. Project coordinator Dr. Clara Menendez stressed the complexities of treating malaria: "the spread of parasite resistance to SP, particularly in Eastern Africa and the significant overlap in some regions of malaria transmission together with a high prevalence of HIV infection have raised concerns about the medium and long-term use of SP for IPTp. Among the current available alternative antimalarial drugs, MQ offers the most comparable advantages to SP".

The Prince Leopold Institute of Tropical Medicine (ITM) has been awarded 3.7 million to undertake research to determine the safety and efficacy of available Artemesinin-based combination treatments (or ACT's) to treat malaria during the second and third trimesters of pregnancy. Project coordinator Prof. Umberto D'Alessandro stated that "by completing a head-to-head comparison of four treatment drugs (Dihydroartermisinin-Piperaquine,

Mefloquine-Artesunate, Amodiaquine-Artesunate and Artemether-Lumefantrine), we can identify not only valid first line treatments but also second line rescue treatments, aimed at informing WHO guidelines and drug policy in endemic countries".

All three research projects include a significant element of capacity building in the African host nations, including infrastructural upgrading of fifteen research sites (five per project) and a series of short term training c
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Contact: Alan Hughes
a.p.hughes@liv.ac.uk
Liverpool School of Tropical Medicine
Source:Eurekalert  

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