Navigation Links
MiP Consortium awarded €11 million by EDCTP
Date:5/8/2009

The global Malaria in Pregnancy (MiP) Consortium, led by the Liverpool School of Tropical Medicine, has been awarded 11 million by the European and Developing Countries Clinical Trials Partnership (EDCTP) to undertake three new strands of research in Africa. The three grant recipients the Liverpool School of Tropical Medicine, the Barcelona Center for International Health Research in Spain and the Prince Leopold Institute of Tropical Medicine in Belgium will evaluate new and improved existing interventions for the prevention and treatment of malaria in pregnancy, which places up to 50 million women at risk every year.

Malaria in pregnancy is a major cause of severe maternal anaemia and preventable low birth weight in infants, which greatly increases the risk of infant death. In Africa, where malaria is endemic in most countries, its complications are responsible for as many as 100,000 infants dying needlessly every year. Malaria also accounts for approximately 10% of maternal deaths, suggesting that an estimated 25,000 maternal deaths could be prevented each year by improved control of malaria in pregnancy.

The Liverpool School of Tropical Medicine (LSTM) has been awarded 3.6 million to undertake research to optimise the use of a particular antimalarial drug, sulphadoxine-pyrimethamine or SP, given to prevent malaria in pregnancy in Africa. Intermittent preventive treatment (IPTp) has proven highly effective in reducing the adverse effects of malaria infection in pregnant women and improving birth weight (and hence survival rates) in infants. The project is seeking to optimise the regimen of SP, which is used widely as IPTp whilst also looking at alternative approaches to IPTp. Consortium leader and project coordinator Professor Feiko ter Kuile explained the significance and future relevance of the activities led by LSTM: "SP is one of the main antimalarials used for the control of malaria in pregnancy, but despite ten years of widespread use, uncertainties about the optimal dose remain. This project will allow us to explore whether pregnant women need a different dose to non-pregnant women because of changes in the way the drug is assimilated during pregnancy. The results of this research will be used to inform WHO policy recommendations on the use of SP."

The Barcelona Center for International Health Research (CRESIB) has been awarded 3.6 million to undertake research to evaluate different drug alternatives, mefloquine (or MQ) and SP, for use as IPTp in the context of insecticide treated nets to prevent malaria in pregnancy. Project coordinator Dr. Clara Menendez stressed the complexities of treating malaria: "the spread of parasite resistance to SP, particularly in Eastern Africa and the significant overlap in some regions of malaria transmission together with a high prevalence of HIV infection have raised concerns about the medium and long-term use of SP for IPTp. Among the current available alternative antimalarial drugs, MQ offers the most comparable advantages to SP".

The Prince Leopold Institute of Tropical Medicine (ITM) has been awarded 3.7 million to undertake research to determine the safety and efficacy of available Artemesinin-based combination treatments (or ACT's) to treat malaria during the second and third trimesters of pregnancy. Project coordinator Prof. Umberto D'Alessandro stated that "by completing a head-to-head comparison of four treatment drugs (Dihydroartermisinin-Piperaquine,

Mefloquine-Artesunate, Amodiaquine-Artesunate and Artemether-Lumefantrine), we can identify not only valid first line treatments but also second line rescue treatments, aimed at informing WHO guidelines and drug policy in endemic countries".

All three research projects include a significant element of capacity building in the African host nations, including infrastructural upgrading of fifteen research sites (five per project) and a series of short term training courses in Good Clinical Practice (GCP), Good Clinical Laboratory Practice (GCLP), clinical trial methodology, research ethics, statistics, and data and research management. Several longer term training positions involving MSc and PhD scholarships will also be awarded.


'/>"/>

Contact: Alan Hughes
a.p.hughes@liv.ac.uk
Liverpool School of Tropical Medicine
Source:Eurekalert  

Related medicine news :

1. University HealthSystem Consortium Selects Sodexo to Provide Food and Nutrition Services
2. HBO, the Arizona Alzheimers Consortium and the Alzheimers Association, Desert Southwest Chapter Present a Free Advance Screening of THE ALZHEIMERS PROJECT: Momentum In Science
3. Kings-led consortium wins €1 million EU funding for Chinese medicine research
4. University HealthSystem Consortium Launches Tactics for Tough Times Initiative to Help Members With Issues Such as Capacity and Medication Management
5. University HealthSystem Consortium Selects Morehead to Provide Employee Satisfaction and Consulting Services
6. University HealthSystem Consortium Names Ascent Healthcare Solutions Supplier of the Year at UHC 2009 Performance Excellence Forum
7. Garvan to play a role in International Cancer Genome Consortium
8. University HealthSystem Consortium Selects KONE to Provide Elevator Maintenance Services
9. LSTM and MiP Consortium awarded further $4.5 million
10. S.C.-Based Technology Consortium Names Interim Executive Director and Board
11. University HealthSystem Consortium Selects Cartus to Provide Relocation Services
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
MiP Consortium awarded €11 million by EDCTP
(Date:6/26/2016)... Michigan (PRWEB) , ... June 26, 2016 , ... On ... as sponsor of the 2016 Cereal Festival and World’s Longest Breakfast Table in Battle ... honor of the city’s history as home to some of the world’s leading providers ...
(Date:6/26/2016)... ... June 26, 2016 , ... PawPaws brand pet ... product that was developed to enhance the health of felines. The formula is all-natural ... two main herbs in the PawPaws Cat Kidney Support Supplement Soft Chews ...
(Date:6/26/2016)... Orion, Clarkston, Michigan (PRWEB) , ... June 26, ... ... with respect to fertility once they have been diagnosed with endometriosis. These women ... intercourse but they also require a comprehensive approach that can help for preservation ...
(Date:6/25/2016)... ... June 25, 2016 , ... Austin residents seeking Mohs surgery services, can now ... and to Dr. Russell Peckham for medical and surgical dermatology. , Dr. Dorsey brings ... The selective fellowship in Mohs Micrographic Surgery completed by Dr. Dorsey was under the ...
(Date:6/25/2016)... ... June 25, 2016 , ... "With 30 hand-drawn hand ... project," said Christina Austin - CEO of Pixel Film Studios. , ProHand Cartoon’s ... within Final Cut Pro X . Simply select a ProHand generator and drag ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... -- Research and Markets has announced ... Applications, Technologies, Forecasts" report to their offering. ... Smart Skin, Structural Health Monitoring, Composite Smart Structures, ... involves electronic and/or electrical components and circuits that ... such as vehicle bodies or conformally placed upon ...
(Date:6/24/2016)... India , June 24, 2016 ... Needles Market by Type (Standard Pen Needles, Safety Pen ... Therapy (Insulin, GLP-1, Growth Hormone), Mode of Purchase (Retail, ... by MarketsandMarkets, This report studies the market for the ... expected to reach USD 2.81 Billion by 2021 from ...
(Date:6/23/2016)... 2016 Research and Markets has announced ... Forecast to 2022" report to their offering. ... the patients with kidney failure, it replaces the function of ... patient,s blood and thus the treatment helps to keep the ... balance. Increasing number of ESRD patients & ...
Breaking Medicine Technology: