Navigation Links
Metobolomics uncovers key indicators of nonalcoholic fatty liver disease
Date:11/23/2009

A recent metobolomics study by researchers from Virginia Commonwealth University Medical Center in Richmond found that impaired peroxisomal oxidation of polyunsaturated fatty acids (PUFA) is associated with the progression of nonalcoholic fatty liver (NAFL) to nonalcoholic steatohepatitis (NASH). The study also found significantly higher plasma monounsaturated fatty acids in the blood of patients with NAFL and NASH. Full findings appear in the December issue of Hepatology, a journal published by Wiley-Blackwell on behalf of the American Association for the Study of Liver Diseases.

Nonalcoholic fatty liver disease (NAFLD) affects a third of the U.S. adult population, with many cases found in obese individuals. NAFLD ranges from NAFL, a benign condition where fat accumulates in the liver of people who drink little or no alcohol, to a more serious state known as NASH where inflammation or scarring of the liver occurs and which can progress to liver failure.

Study participants included 50 in a lean normal control, 25 subjects with NAFL and 50 patients with NASH. Researchers classified the NAFL group by a diagnosis of fatty liver with the presence of accumulated liver fat of at least grade 1 severity according to the NASH Clinical Research Network criteria. The NASH group included those with at least a grade 1 severity in accumulated liver fat, inflammation and cytologic ballooning of at least grade 1 severity in each. The nonalcoholic nature of the disease was established by clinical assessment that the alcohol consumption was less than 20 gm/day for women and 30 gm/day for men. Lean normal controls were identified by a body mass index between 18-25 kg/m2, absence of symptoms or signs of disease, normal liver enzymes and hepatic sonogram.

The research team, headed by Arun Sanyal, M.B.B.S., M.D., used mass spectrometry (a technique that determines the basic composition of a sample) to analyze blood lipids and metabolites of the NAFL and NASH subjects comparing them with the control group. Data revealed that the development of NAFL is accompanied by increased lipogenesis, ∆ 9 desaturase and LOX activity. "Our study provides the most comprehensive picture of lipid metabolism in NAFLD to date," said Dr. Sanyal.

Results indicate that when the condition of the liver progresses to NASH the lipogenic activity levels off or declines modestly while the LOX activity increases. Simultaneously, there is impaired peroxisomal PUFA metabolism and increase in levels of products of non-enzymatic oxidation of arachidonic acid. "Further study of the role specific metabolic pathways play in the establishment and progression of NASH are needed," concluded Dr. Sanyal. "Our findings serve as a basis for future research of NAFLD."


'/>"/>

Contact: Dawn Peters
medicalnews@wiley.com
781-388-8408
Wiley-Blackwell
Source:Eurekalert

Related medicine news :

1. U-M study uncovers key to how triggering event in cancer occurs
2. Hard to Treat Diseases, Inc. (HTDS) Attorney Brad Essman Uncovers Reports of Retail Brokers Making False Statements
3. OCI Analytic Uncovers Duplicate Billing in Over 4% Of Workers Comp Claims
4. Worlds largest DNA scan for autism uncovers new gene variant for disorder
5. Further Testing With Breast-Specific Gamma Imaging (BSGI) Uncovers Additional Cancer in Breast Cancer Patients, Changes Surgical Management
6. Team Uncovers Discrepancy in Death Certificates Listing Suicide
7. Article One Partners Uncovers New Prior Art Impacting the Validity of Mercks SINGULAIR Patent
8. Breast-Specific Gamma Imaging (BSGI) Uncovers Additional Breast Cancer in Newly Diagnosed Breast Cancer Patients
9. Discovery Health Uncovers the Truth With Its Mystery March Programming Event
10. OHSU School of Dentistry uncovers mechanism for dental pain
11. Lumension Uncovers Results of Security Data Protection Survey
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/28/2017)... ... April 28, 2017 , ... Intellitec Solutions announced ... Foundation implement a Microsoft Dynamics GP solution that integrates to their PointClickCare EHR ... specializes in long-term care, Brooke Grove now has the capability to achieve its ...
(Date:4/28/2017)... ... April 28, 2017 , ... Semrock’s highly popular SearchLight Spectra ... modeling resource for fluorescence microscopists and optical system designers, enabling The Right Solution, ... spanning the globe, SearchLight has become a tremendously popular tool for the fluorescence ...
(Date:4/27/2017)... (PRWEB) , ... April 27, 2017 , ... Healthcare companies ... But they will rapidly reject an outdated healthcare executive resume. , “If you’re a ... at your executive resume and wondering if it’s as ready as you are for ...
(Date:4/27/2017)... Reston, VA (PRWEB) , ... April 27, 2017 ... ... mobile application containerization, today announced an exhibitor sponsorship at MobileIron Live! 2017 ... leaders, and new technologies for an immersive, educational approach to helping organizations maximize ...
(Date:4/27/2017)... ... April 27, 2017 , ... Plastic Surgery Associates is excited to announce ... present at the upcoming Aesthetic Meeting. Held in San Diego, at the San Diego ... Canales will lend their expertise to the Premier Global Hot Topics session, speaking on ...
Breaking Medicine News(10 mins):
(Date:4/20/2017)... 20, 2017  CVS Pharmacy, the retail division ... new store design to enhance the retail customer ... health-focused products and expanded beauty selections paired with ... discover new offerings. Together with its innovative digital ... the customer experience at CVS Pharmacy.  ...
(Date:4/20/2017)... Eyevensys, a private biotechnology company ... expression technology that enables the safe, local, sustained production ... wide range of ophthalmic diseases, announces it has received ... Agency (MHRA) to advance its technology into clinical development. ... The EyeCET ...
(Date:4/19/2017)... , April 19, 2017 Cardiology devices segment is ... period The Cardiology Devices segment is likely to ... 15 Mn in 2018 over 2017. By the end of ... valuation close to US$ 700 Mn, expanding at a CAGR ... dominated the Asia Pacific reprocessed medical ...
Breaking Medicine Technology: