Navigation Links
Method to estimate LDL-C may provide more accurate risk classification
Date:11/17/2013

Chicago Seth S. Martin, M.D., of the Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Baltimore, and colleagues developed a method for estimating low-density lipoprotein cholesterol (LDL-C) levels that is more accurate than the standard measure.

Low-density lipoprotein cholesterol is the primary target for treatment in national and international clinical practice guidelines. Conventionally, LDL-C is estimated by the Friedewald equation, which estimates LDL-C as (total cholesterol) - (high-density lipoprotein cholesterol [HDL-C]) - (triglycerides/5) in mg/dL. The final term assumes a fixed ratio of triglyceride levels to very low-density lipoprotein cholesterol (TG:VLDL-C) of 5:1. "Applying a factor of 5 to every individual patient is problematic given variance in the TG:VLDL-C ratio across the range of triglyceride and non-HDL-C levels," according to background information in the study.

The researchers used a sample of lipid profiles obtained from 2009 through 2011 from 1,350,908 children, adolescents, and adults in the United States.

From this large sample of lipid profiles, the authors created and validated a novel method to estimate LDL-C from the standard lipid profile, consisting of a 180-cell table (grid) of median TG:VLDL-C values based on triglyceride and non-HDL-C values. Rather than assuming a fixed factor of 5, it applies an adjustable factor for the TG:VLDL-C ratio based on triglyceride and non-HDL-C concentrations. "The greatest advantage occurs in classification of LDL-C concentrations lower than 70 mg/dL, especially in patients with elevated triglyceride concentrations. In addition to the novel analytic approach, a major strength of this study is its size, 3,015 times larger than the original Friedewald database."

"These findings require external validation, as well as assessment of their clinical importance. The novel method could be easily implemented in most laboratory reporting systems at virtually no cost."


'/>"/>

Contact: Ellen Beth Levitt
eblevitt@jhmi.edu
410-598-4711
The JAMA Network Journals
Source:Eurekalert

Related medicine news :

1. Nonsurgical Method to Measure Brain Pressure Shows Promise
2. New Method to Reveal Alzheimers Marker Shows Promise
3. New method to measure work addiction
4. Advanced genetic screening method may speed vaccine development
5. OHSU Oregon National Primate Research Center develops new, safer method for making vaccines
6. Hear to see: New method for the treatment of visual field defects
7. Safer Grilling Methods Might Cut Cancer Risk
8. Quick-Reversal Method May Be at Hand for New Blood Thinner
9. New delivery method improves efficacy of 2 common Parkinsons disease medications
10. Electronic data methods research seeks to build a learning health care system
11. New Stanford method enables sequencing of fetal genomes using only maternal blood sample
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/20/2020)... MILFORD, Pa. (PRWEB) , ... February 20, 2020 , ... ... Cosmetic Dermatology Surgery & Laser Center in Milford, Penn requesting treatments to achieve “ ... 2019. And it doesn’t look like it is slowing down into 2020. It’s a ...
(Date:2/19/2020)... ... February 19, 2020 , ... Drs. Richard ... Implant Center of Connecticut, celebrate 30 years of serving Monroe, CT with a ... fees that they charged in 1989, only thirty dollars. To further serve their ...
(Date:2/19/2020)... , ... February 19, 2020 , ... ... Start Up Founders Encouraged to Apply to Participate in 2020 Cohort , The ... MedTech IGNITE program is now accepting applications from startup founders and CEOs ...
(Date:2/19/2020)... ... February 19, 2020 , ... ... highlight its growing product portfolio for lower extremities at the American College of ... Gonzalez Convention Center. The Trigon® Ti Stand-Alone Osteotomy Wedge Fixation System will lead ...
(Date:2/16/2020)... ... February 16, 2020 , ... Accumen Inc., the ... with AABB and The Joint Commission to provide a complimentary series of Patient ... managers, coordinators and transfusion safety officers) within U.S. hospitals. , “Accumen’s ...
Breaking Medicine News(10 mins):
(Date:2/21/2020)... ... ... Special Learning, Inc. is the leading global provider of Autism and Applied ... of people with autism and other special needs. , It has recently ... Special Learning will be providing some of the key components of a comprehensive training ...
(Date:2/20/2020)... ... February 20, 2020 , ... NeoTract, a wholly owned subsidiary ... urology, today announced that Jayant Uberoi, MD, Chesapeake Urology in Baltimore MD, has ... Uberoi has achieved a high level of training and experience with the UroLift® ...
(Date:2/19/2020)... ... February 19, 2020 , ... Today, ... skilled nursing facility rehospitalization rate are the lowest in the company’s history. ... 29 percent drop year over year. GHC’s skilled nursing facility (SNF) rehospitalization rate ...
Breaking Medicine Technology: