Navigation Links
Method to estimate LDL-C may provide more accurate risk classification
Date:11/17/2013

Chicago Seth S. Martin, M.D., of the Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Baltimore, and colleagues developed a method for estimating low-density lipoprotein cholesterol (LDL-C) levels that is more accurate than the standard measure.

Low-density lipoprotein cholesterol is the primary target for treatment in national and international clinical practice guidelines. Conventionally, LDL-C is estimated by the Friedewald equation, which estimates LDL-C as (total cholesterol) - (high-density lipoprotein cholesterol [HDL-C]) - (triglycerides/5) in mg/dL. The final term assumes a fixed ratio of triglyceride levels to very low-density lipoprotein cholesterol (TG:VLDL-C) of 5:1. "Applying a factor of 5 to every individual patient is problematic given variance in the TG:VLDL-C ratio across the range of triglyceride and non-HDL-C levels," according to background information in the study.

The researchers used a sample of lipid profiles obtained from 2009 through 2011 from 1,350,908 children, adolescents, and adults in the United States.

From this large sample of lipid profiles, the authors created and validated a novel method to estimate LDL-C from the standard lipid profile, consisting of a 180-cell table (grid) of median TG:VLDL-C values based on triglyceride and non-HDL-C values. Rather than assuming a fixed factor of 5, it applies an adjustable factor for the TG:VLDL-C ratio based on triglyceride and non-HDL-C concentrations. "The greatest advantage occurs in classification of LDL-C concentrations lower than 70 mg/dL, especially in patients with elevated triglyceride concentrations. In addition to the novel analytic approach, a major strength of this study is its size, 3,015 times larger than the original Friedewald database."

"These findings require external validation, as well as assessment of their clinical importance. The novel method could be easily implemented in most laboratory reporting system
'/>"/>

Contact: Ellen Beth Levitt
eblevitt@jhmi.edu
410-598-4711
The JAMA Network Journals
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Nonsurgical Method to Measure Brain Pressure Shows Promise
2. New Method to Reveal Alzheimers Marker Shows Promise
3. New method to measure work addiction
4. Advanced genetic screening method may speed vaccine development
5. OHSU Oregon National Primate Research Center develops new, safer method for making vaccines
6. Hear to see: New method for the treatment of visual field defects
7. Safer Grilling Methods Might Cut Cancer Risk
8. Quick-Reversal Method May Be at Hand for New Blood Thinner
9. New delivery method improves efficacy of 2 common Parkinsons disease medications
10. Electronic data methods research seeks to build a learning health care system
11. New Stanford method enables sequencing of fetal genomes using only maternal blood sample
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... PA (PRWEB) January 22, 2015 Woodloch Pines, ... Mountains, has been selected by TripAdvisor as the number one ... the 6th best in the world for their annual Travelers’ ... online travel community . The website is home to millions ...
(Date:1/22/2015)... Angelweddingdress is a famous wedding dress company ... to follow it on Facebook, Twitter, and Pinterest. The fans ... Angelweddingdress draws a lottery every week. , Moreover, the company ... 2015. Click Angelweddingdress homepage for more information. ...
(Date:1/22/2015)... Dallas, TX (PRWEB) January 22, 2015 ... the issue of experience and person-centeredness in the long-term ... moving towards action across the continuum. The paper, “The ... the Continuum,” engages perspectives and practices of the patient, ...
(Date:1/22/2015)... 22, 2015 Joan Lunden, award-winning American ... at the upcoming 32nd Annual Miami Breast Cancer ... Education Resource®, LLC (PER®) , shares that “a fast-growing, ... undetected if she had not followed up her clean ...
(Date:1/22/2015)... 2015 Four years since the release of their ... with the marriage of Avasa & Matthew Love – the duo ... scheduled for release through White Swan Records on February 24, 2015. ... a sacred path available to all of us to walk out ...
Breaking Medicine News(10 mins):Health News:TripAdvisor Names Woodloch Pines Best Hotel for Families in America 2Health News:TripAdvisor Names Woodloch Pines Best Hotel for Families in America 3Health News:Angelweddingdress Invites Its Customers To Follow It On Facebook, Twitter, And Pinterest 2Health News:The Power of Person-Centeredness in Long-Term Care Explored by The Beryl Institute 2Health News:The Power of Person-Centeredness in Long-Term Care Explored by The Beryl Institute 3Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 2Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 3Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 4Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 5Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 6Health News:THE ROAD by Avasa & Matthew Love -- A New Album 2Health News:THE ROAD by Avasa & Matthew Love -- A New Album 3Health News:THE ROAD by Avasa & Matthew Love -- A New Album 4
... Feb. 21 AK Steel (NYSE:,AKS) said today that ... agreement between AK Steel and a group of retirees ... from the company,s,initiatives in 2006 to reduce its health ... settlement agreement, which established a Voluntary Employees,Beneficiary Association (VEBA) ...
... Feb. 21 The needs of,pregnant women, babies and toddlers ... Healthy Start of Southwest Florida has received a $6,000,grant from ... how we,can best help the 18,000 clients we serve each ... in the last five,years. The population has increased and the ...
... new electron microscope recently installed in Cornell,s Duffield Hall ... images that uniquely identify individual atoms in a crystal ... And in living color. , "The current generation of ... and white cameras where different atoms appear as different ...
... whose discoveries have led to fundamental advances in the ... two prestigious international prizes offered by the Kirk A. ... for Cancer Research (AACR). , The Kirk A. ... Landon-AACR Prize for Translational Cancer Research are among the ...
... Sons, Inc. (NYSE: JWa), (NYSE: JWb), today announced that it ... its worldwide operations that were formerly part of Blackwell Publishing, ... addition to offsetting the carbon footprint of 10 offices around ... that result from the global product shipments from this part ...
... of adverse side effects , , THURSDAY, Feb. ... one nonsteroidal anti-inflammatory drug (NSAID) may have poorer health-related ... which are available in both prescription and over-the-counter (OTC) ... drugs are widely available, and patients may take both ...
Cached Medicine News:Health News:U.S. Court Approves AK Steel's VEBA Health Care Settlement With Middletown Works Retirees 2Health News:Healthy Start of Southwest Florida Receives Grant From March of Dimes to Assess Needs of Pregnant Women and Babies 2Health News:By color-coding atoms, new Cornell electron microscope promises big advance in materials analysis 2Health News:By color-coding atoms, new Cornell electron microscope promises big advance in materials analysis 3Health News:AACR's Seventh Annual Landon Awards 2Health News:AACR's Seventh Annual Landon Awards 3Health News:AACR's Seventh Annual Landon Awards 4Health News:AACR's Seventh Annual Landon Awards 5Health News:Taking Multiple Pain Relievers May Cause Complications 2
(Date:1/23/2015)... DES MOINES, Iowa , Jan. 23, 2015  The Partnership to ... Iowa health care leaders and a new study ... prescription medications. The PFCD is a nationwide coalition working to educate ... The research released at the Capitol was focused on how the ...
(Date:1/23/2015)... 23, 2015  MedScope ( www.medscope.org ), the leading provider ... 2015 Connected World magazine Connected World Award ... that can be used anywhere, anytime. The nomination was ... In nominating MedScope, Landon Garner , Director ...
(Date:1/23/2015)... 2015 /PRNewswire/-- Harwood Feffer LLP ( www.hfesq.com ) is investigating ... Inc. ("Advaxis" or the "Company") (NASDAQ: ADXS ... duties to shareholders. On January 21, 2015, ... that Advaxis had misrepresented the clinical data for its ...
Breaking Medicine Technology:New research shows Iowa health exchange would benefit from improvements 2New research shows Iowa health exchange would benefit from improvements 3MedScope Nominated by RacoWireless for Prestigious 2015 Connected World Magazine Connected World Award 2Harwood Feffer LLP Announces Investigation of Advaxis, Inc. 2
... 20, 2011 Isis Pharmaceuticals, Inc. (Nasdaq: ISIS ... PresentationWhen: , Thursday, January 05, 2012 at 9:00 a.m. PT ... Live on the Internet.  Simply log on to our Web ... the live event, a replay of the webcast will be ...
... 2011  Double Eagle Holdings, Ltd. (OTCQB: DROP), the parent ... today the formal launch of its Hypoglycemic, Hyperglycemic, and ... and pharmaceutical licensing efforts.   Some of ... are oral fuse delivery technologies (OFD,s). These OFD,s are ...
Cached Medicine Technology:Fuse Science Announces the Launch of its Analgesic and Diabetic Oral Fuse Delivery (OFD) Research Project Platforms 2Fuse Science Announces the Launch of its Analgesic and Diabetic Oral Fuse Delivery (OFD) Research Project Platforms 3
Blunt cannula for injection or aspiration of fluid. Thinwall cannula allows high flow rate. Blunt tip is smooth all around for easy insertion. Luer lock hub for easy, secure connection to a backflus...
PLX30s, 30 Watt Sealed CO2 Laser System....
... Pulse sealed CO2 surgical lasers offer unmatched ... experience and support services of a company ... experience. All settings are available at the ... Super Pulse surgical lasers are compatible with ...
Ophthalmic Nd Yag Laser with excellent quality optics for clear image and good laser delivery. Compact and light-weight for portability....
Medicine Products: