Navigation Links
Method patent issued for investigational new class of pain medication
Date:1/25/2013

, but only in those cells that express VR1.

"Capsaicin is the equivalent of trying to put out a house fire with a low-pressure garden hose," said Andrew Mannes, M. D., a scientist with NIH's Clinical Center, who is involved in RTX's clinical development. "RTX acts like a high-pressure fire hose. Just as the heavy blast of water from the fire hose can extinguish the flames, the heavy influx of calcium that RTX causes overwhelms the specific nerve cells that carry painful sensations and kills them."

Because nerve cells in the peripheral nervous system must first route their sensory signals to the spine, where they then are processed and sent onward to the brain, Iadarola's finding raised an intriguing therapeutic scenario: The cell bodies of these peripheral neurons bundle together in groups near the spine. If RTX were applied intrathecally and directly to the bundles, called dorsal root ganglia, the scientists believed that they could selectively kill specific neurons that express large amounts of the VR1 protein on their surface. By doing this, they also could turn off permanently certain painful sensations, such as noxious heat and certain inflammatory signals that can be involved in severe arthritis, peripheral neuromas, trigeminal neuralgia, and advanced cancer.

The research baton soon passed to NIH's National Institute on Drug Abuse to perform the needed toxicology studies on the intrathecal administration of RTX. Once completed, staff at the NIH Clinical Center painstakingly formulated RTX and produced the needed supply of the drug for NIH's current early-phase clinical study. The investigation is co-supported by NIDCR and NINDS.

"In recent years, NIH scientists have worked to enhance pain research and promote collaboration in the field," said NINDS Director Story Landis, Ph.D. "The unique scientific collaboration of five NIH components leading up to today's announcement has created an opportunity to develop a compound th
'/>"/>

Contact: Bob Kuska
kuskar@nidcr.nih.gov
301-594-7560
NIH/National Institute of Dental and Craniofacial Research
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. New method identifies genes that can predict prognoses of cancer patients
2. New Book The MELT Method Offers a Breakthrough Self-Treatment System to Eliminate Chronic Pain, Erase the Signs of Aging, and Feel Fantastic in Just 10 Minutes a Day!
3. Kantar Health Further Strengthens Its Advanced Methods and Client Consulting Capabilities in the UK
4. Developed new method to diagnose hereditary breast and ovarian cancer
5. When Can You Get Pregnant? Many Women Don’t Know, But a Simple Family Planning Method Now Available from Cycle Technologies Can Help
6. Research Reveals Which Learning Methods Get an A
7. New Research Survey Indicates That Natural Family Planning Method CycleBeads® Helps Women Planning Pregnancies
8. Targeted gene silencing drugs are more than 500 times more effective with new delivery method
9. Methodist Retirement Communities Set to Open the First Memory Support Community in Huntsville, TX Area
10. Method developed by VTT targets diagnosis of early Alzheimers disease
11. Researchers explore social media as preventative method for infectious diseases
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/1/2014)... Building on the success of the 2014 ... Breathing Academy (ASBA) has officially announced its 2015 ... The event will be taking place at the DoubleTree ... This years’ event promises to be yet another educational ... In recent years, Pro Player Health Alliance ...
(Date:9/1/2014)... health and substance use problems in adolescents but ... consequences of cyberbullying and also be beneficial for ... Ph.D., of McGill University, Montreal, Canada, and colleagues. ... experienced recent online bullying and cyberbullying, like traditional ... problems in teens as well as the misuse ...
(Date:9/1/2014)... You may be able to convince your brain that healthy ... The study included eight overweight and obese people who were ... how people react to different foods. These participants were compared ... who weren,t in the program. Both groups had MRI ... six months later. The scans revealed that the people in ...
(Date:9/1/2014)... Currently, scientists continue to face ... Alzheimer's disease (AD), which reflects their poor understanding ... diagnosis of the disease, especially in its early ... tests. In 2014, after decades that have ... the medicine world, there are still no disease-modifying ...
(Date:9/1/2014)... 01, 2014 "Women struggle with weight ... daily changes begin as early as 15, if not ... negotiating the ups and downs of hormone related weight ... even healthy sizes seems to rage against the hidden ... woman in her 40's begin to face menopause and ...
Breaking Medicine News(10 mins):Health News:Pro Player Health Alliance Confirms Big Name Speakers at 2015 American Sleep and Breathing Academy Conference 2Health News:Pro Player Health Alliance Confirms Big Name Speakers at 2015 American Sleep and Breathing Academy Conference 3Health News:Pro Player Health Alliance Confirms Big Name Speakers at 2015 American Sleep and Breathing Academy Conference 4Health News:Family dinners good for teens' mental health, could protect from cyberbullying 2Health News:Family dinners good for teens' mental health, could protect from cyberbullying 3Health News:Train Your Brain to Choose Fruit Salad Over French Fries 2Health News:Early Stage Minimally Invasive Candidate AD Biomarkers Reviewed in New Study by Biopharm Reports Available at MarketPublishers.com 2Health News:Early Stage Minimally Invasive Candidate AD Biomarkers Reviewed in New Study by Biopharm Reports Available at MarketPublishers.com 3Health News:Female Hormonal Imbalances - Can’t Seem to Shed Those Extra Pounds? Discussion with Medical Expert Dr. Clairborne on Dr. Carol Francis Talk Radio Today 2Health News:Female Hormonal Imbalances - Can’t Seem to Shed Those Extra Pounds? Discussion with Medical Expert Dr. Clairborne on Dr. Carol Francis Talk Radio Today 3
... Pa., Nov. 21 Universal,Health Services, Inc. (NYSE: ... to pay a cash dividend of $0.08 per share ... December 3, 2007., Universal Health Services, Inc. is ... and behavioral health hospitals, and,ambulatory centers nationwide and in ...
... counters idea that seniors are by nature sedentary , WEDNESDAY, ... believe that becoming less active is just a normal part ... to dispel such notions. , The program led to a ... of walking participants did each week, according to the leaders ...
... egg follicles, mouse study shows , , WEDNESDAY, Nov. 21 ... by which a mother,s smoking before and after pregnancy ... two-thirds. , Cigarette smoking during pregnancy has been shown ... woman,s offspring, but this is the first study to ...
... at St. Jude Children,s Research Hospital have discovered a ... amok and damaging the body. The finding could lead ... vaccines; for autoimmune diseases, such as Type 1 diabetes; ... (IBD) and asthma. , The St. Jude team ...
... would you do if you,suddenly found yourself unable to ... a drinker, exercised and got an adequate amount of,sleep ... suffered a stroke. In his new,book, "My Glitch: Personal ... -- http://www.authorhouse.com ), Beel shares his,experiences of being ...
... 8 a.m. CT, MINNEAPOLIS, Nov. 21 Vital ... enterprise-wide advanced,visualization and analysis solutions, will Webcast its analyst ... of the Radiological,Society of North America (RSNA), on Monday, ... D. Miller, president and chief executive officer, and Michael ...
Cached Medicine News:Health News:Aging Isn't About Slowing Down, Experts Say 2Health News:Smoking Before, After Pregnancy Harms Daughters' Fertility 2Health News:Smoking Before, After Pregnancy Harms Daughters' Fertility 3Health News:Smoking Before, After Pregnancy Harms Daughters' Fertility 4Health News:St. Jude finds molecule that could improve cancer vaccines and therapy for other diseases 2Health News:St. Jude finds molecule that could improve cancer vaccines and therapy for other diseases 3Health News:The Blessing of a Brain Injury: Author Survives Injury to Brain Following Stroke, Uses Injury as Fuel to Overcome Odds 2Health News:Vital Images to Webcast Analyst and Investor Meeting at RSNA on Monday, November 26 2
(Date:8/29/2014)... WEST JORDAN, Utah , Aug. 29, 2014 /PRNewswire/ ... Imaging Solutions, has acquired Polaris Medical Imaging, a leader ... CT scanners. This strategic acquisition allows BC Technical to ... their capabilities, specifically within MR and CT modalities. ... lower cost service," said Mark Alvarez , president ...
(Date:8/29/2014)... Research and Markets has announced the addition ... Pipeline Insight 2014" report to their offering. ... eradicate the prevalence of cancer have achieved limited success ... specificity, safety and large number of side effects, which ... It has been discovered that peptides can be used ...
(Date:8/29/2014)... According to a new ... type (SFE, Cold Pressed, Organic Solvent, & Others), and ... Fragrance, & Others) - Global Trends & Forecast ... the Amaranth Seed Oil Market with an analysis ... of value. The Amaranth Seed Oil Market size ...
Breaking Medicine Technology:BC Technical Acquires Polaris Medical Imaging 2Global Peptide Cancer Therapeutics Market & Pipeline Insight 2014 2Amaranth Seed Oil Market worth $700.6 Million by 2019 2Amaranth Seed Oil Market worth $700.6 Million by 2019 3Amaranth Seed Oil Market worth $700.6 Million by 2019 4
... SAN DIEGO, May 26, 2011 Volcano Corporation ... following statement: Earlier this year, the ... a wholly-owned subsidiary of St. Jude Medical, that ... misappropriated LightLab,s confidential information in connection for use ...
... YORK, May 26, 2011 A new prostate cancer ... Medicine comparing surgical treatment to "watchful waiting" ... cancer and currently debating their treatment options. ... the most commonly offered clinical options for early prostate ...
Cached Medicine Technology:Statement From Volcano Corporation on Latest St. Jude Lawsuit 2Robotic Prostatectomy Expert Dr. David Samadi on a High Impact Study Advocating Aggressive Early-Stage Prostate Cancer Treatment 2Robotic Prostatectomy Expert Dr. David Samadi on a High Impact Study Advocating Aggressive Early-Stage Prostate Cancer Treatment 3
... Autoref / Ker Accuref K ... inch LCD color monitor. 3 ... range. 2.3 mm Minimum pupil ... light adjuster. Auto start function. ...
... is the child-friendly, portable autorefractor that ... adults. It can perform objective refraction ... cm) away even through glasses and ... and sounds engage the patient throughout ...
Neomycin and Polymyxin B sulfates and Dexamethasone ophthalmic ointment is a multiple dose anti-infective steroid combination in sterile ointment form for topical applications....
Optoelectronic stimulator, "ganzfeld" stimulations for flash VEP, flash ERG and sensory EOG. Pattern stimulations for ERG and VEP, multifocal stimulations for ERG and VEP, complies with international...
Medicine Products: