Navigation Links
Method patent issued for investigational new class of pain medication
Date:1/25/2013

y of RTX that investigates the safety and efficacy of RTX administered intrathecally to advanced cancer patients with severe pain. The study continues to recruit patients, and more information can be found at:

http://cancerpainstudynih.com and www.clinicaltrials.gov

RTX first came to the attention of researchers in the mid 1970s when German scientists isolated it as the active compound in a dried white resin and centuries-old folk remedy that is extracted from a spiny, cactus-like plant called Euphorbia resinifera. The discovery soon caught the investigative eye of Dr. Peter Blumberg, a scientist with NIH's National Cancer Institute (NCI). He was intrigued by RTX's unique chemical structure, a natural hybrid between capsaicin, the irritant in red peppers, and daphnane, a unique class of plant-derived, irritant compounds.

Blumberg received several patents in the United States and abroad during the late 1980s and early 1990s related to RTX. He and his colleagues showed among their many discoveries that the compound was a 1,000 times more potent than capsaicin when binding to the surface of certain types of heat-pain sensing neurons. While Blumberg and colleagues laid the scientific groundwork, the optimal means to administer RTX as a new, ultra-potent class of pain medication remained open for discovery.

In the early 2000s, Dr. Michael Iadarola, a basic scientist with NIH's National Institute of Dental and Craniofacial Research (NIDCR), and colleagues began to piece together one such alternative. They had homed in on RTX's reported unique ability to bind to a much studied protein called vanilloid receptor 1 (VR1), which is a channel, or pore, displayed on the surface of certain types of heat-pain-sensing neurons, or nerve cells. RTX attaches to VR1, and, like water flowing through a hose, prompts an influx of calcium ions through the channel
'/>"/>

Contact: Bob Kuska
kuskar@nidcr.nih.gov
301-594-7560
NIH/National Institute of Dental and Craniofacial Research
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. New method identifies genes that can predict prognoses of cancer patients
2. New Book The MELT Method Offers a Breakthrough Self-Treatment System to Eliminate Chronic Pain, Erase the Signs of Aging, and Feel Fantastic in Just 10 Minutes a Day!
3. Kantar Health Further Strengthens Its Advanced Methods and Client Consulting Capabilities in the UK
4. Developed new method to diagnose hereditary breast and ovarian cancer
5. When Can You Get Pregnant? Many Women Don’t Know, But a Simple Family Planning Method Now Available from Cycle Technologies Can Help
6. Research Reveals Which Learning Methods Get an A
7. New Research Survey Indicates That Natural Family Planning Method CycleBeads® Helps Women Planning Pregnancies
8. Targeted gene silencing drugs are more than 500 times more effective with new delivery method
9. Methodist Retirement Communities Set to Open the First Memory Support Community in Huntsville, TX Area
10. Method developed by VTT targets diagnosis of early Alzheimers disease
11. Researchers explore social media as preventative method for infectious diseases
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/3/2015)... (PRWEB) , ... August 03, 2015 , ... ... Health notes that while an overwhelming number of Hispanics believe people can ... The overwhelming 70 percent of participants queried said making diet changes was important. ...
(Date:8/3/2015)... (PRWEB) , ... August 03, ... ... bodybuilding and fitness site and the largest online retailer of nutritional supplements, ... BPI Sports is up for 11 awards in the following categories:, ...
(Date:8/3/2015)... Beach, CA (PRWEB) , ... August 03, 2015 ... ... individuals suffering from ALS and amputation , AUGUST 3, 2015 – Since winning ... category in March 2015, Not Impossible – an organization whose mission is to ...
(Date:8/3/2015)... NC (PRWEB) , ... August 03, 2015 , ... The ... by experience. Learning from her grandmother’s side at a young age, Nasreen Zereshki was ... Zereshki has decided to share her cookbook Recipes from My Persian Kitchen with the ...
(Date:8/3/2015)... FL (PRWEB) , ... August 03, 2015 , ... AxoGen, ... nerve injuries, is scheduled to present at the Wedbush Healthcare Conference on Wednesday, August ... A live webcast and subsequent archived replay of the Company’s presentation may be accessed ...
Breaking Medicine News(10 mins):Health News:Hispanics More Likely to Struggle with Misinformation About Diabetes 2Health News:Hispanics More Likely to Struggle with Misinformation About Diabetes 3Health News:Hispanics More Likely to Struggle with Misinformation About Diabetes 4Health News:BPI Sports is Nominated for 11 Different 2015 Bodybuilding.com Supplement Awards 2Health News:BPI Sports is Nominated for 11 Different 2015 Bodybuilding.com Supplement Awards 3Health News:Not Impossible Earns Top Awards for Technologies Benefiting Humanity 2Health News:Not Impossible Earns Top Awards for Technologies Benefiting Humanity 3Health News:Not Impossible Earns Top Awards for Technologies Benefiting Humanity 4Health News:Persian Cuisine: Colorful and Extremely Healthy 2Health News:AxoGen, Inc. to Present at the Wedbush Healthcare Conference 2
... 20 CHF,International has been selected as the ... Fund) new Principal Recipient (PR) for,HIV/AIDS prevention, treatment ... awarded an HIV proposal in Round 3 programming., ... years, CHF will be directly responsible for,managing Honduras, ...
... How familiar are you,with the health of your family ... festivity of the Thanksgiving holiday, taking a good look ... That,s why Acting Surgeon General Steven K. Galson, ... Family History Day.,He encourages everyone to use the occasion ...
... System Sets ... Space-Saving Standard, WARRENDALE, ... EP Mobile MR Injection System today, MEDRAD once again,addresses the ... with market-leading injector technology suited for,small spaces. (Logo: ...
... ... ... Subspecialty,Radiology (F&S) has added 31 subspecialty radiologists to support the,growing ... industry,s largest subspecialty teleradiology network. F&S,radiologists are musculoskeletal, body, cardiac, ...
... day the Los,Angeles Times reported that cancer survivors could ... care proposals, smooth,talking Mitt Romney is slated to discuss ... report, cancer survivors "could not be,sure of getting coverage ... government or job-related plan and had to seek insurance ...
... Irvine, Calif., Nov. 20 2007 Vase or face" When presented ... a vase or the faces of two people, what we observe ... brains. , In this example, whether you see faces ... since the image always stays exactly the same, said John Serences, ...
Cached Medicine News:Health News:CHF International Named Global Fund Principal Recipient in Honduras 2Health News:Acting Surgeon General Encourages Americans to Know Their Health History During Fourth Annual Family History Day 2Health News:Acting Surgeon General Encourages Americans to Know Their Health History During Fourth Annual Family History Day 3Health News:MEDRAD Mobile MR Injector Meets Challenges of MR Trailers 2Health News:Franklin & Seidelmann Adds 31 Subspecialty Radiologists to Support Growing Demand for Subspecialty Expertise 2Health News:Franklin & Seidelmann Adds 31 Subspecialty Radiologists to Support Growing Demand for Subspecialty Expertise 3Health News:Franklin & Seidelmann Adds 31 Subspecialty Radiologists to Support Growing Demand for Subspecialty Expertise 4Health News:Franklin & Seidelmann Adds 31 Subspecialty Radiologists to Support Growing Demand for Subspecialty Expertise 5Health News:Franklin & Seidelmann Adds 31 Subspecialty Radiologists to Support Growing Demand for Subspecialty Expertise 6Health News:Franklin & Seidelmann Adds 31 Subspecialty Radiologists to Support Growing Demand for Subspecialty Expertise 7Health News:Franklin & Seidelmann Adds 31 Subspecialty Radiologists to Support Growing Demand for Subspecialty Expertise 8Health News:Mitt's Millions Can't Buy Iowans Health Care Reform 2Health News:Scientists uncover how the brain controls what the eyes see 2
(Date:7/31/2015)... 31, 2015  In today,s ever-changing marketplace, call centers ... mobile, increasingly connected, and increasingly impatient with slow service. ... interaction channels and tools is driving call centers to ... According to research by benchmarking firm, Best ... segment in a call center study realize the impact ...
(Date:7/31/2015)... 31, 2015 More than 1,500 substance abuse ... convene in Indianapolis Aug. 2-6 ... Mid-Year Training Institute . The week-long training, held at ... one of our nation,s biggest public health challenges – ... Institute is a one-of-a-kind intensive training opportunity, offering more ...
(Date:7/31/2015)... RnRMarketResearch.com adds Syringes and ... that provides an overview of syringes and needles ... in-house databases, secondary and primary research. ... pipeline spread across 124 pages, talking about 13 ... 5 figures is now available at http://www.rnrmarketresearch.com/syringes-and-needles-pipeline-review-2015-market-report.html ...
Breaking Medicine Technology:Best Practices in Building World-Class Consumer & Over-the-Counter Call Centers 2Community Leaders From Across The Country Head To Indianapolis For CADCA 2015 Mid-Year Training Institute Aug. 2-6 2Syringes and Needles Market Products Pipeline Review 2015 Report 2Syringes and Needles Market Products Pipeline Review 2015 Report 3Syringes and Needles Market Products Pipeline Review 2015 Report 4Syringes and Needles Market Products Pipeline Review 2015 Report 5
... July 28, 2011 /PRNewswire-Asia/ -- China Kanghui Holdings (NYSE: ... developer, manufacturer and marketer of orthopedic implants in China, today ... financial results on August 16, 2011, before the market opens. ... a.m. ET on August 16, 2011 to discuss second quarter ...
... Soligenix, Inc. (Soligenix or the Company) (OTC BB: ... amendment of its North American licensing partnership with Sigma ... development and commercialization of orBec® (oral beclomethasone dipropionate or ... part of the amended agreement, Sigma - Tau has ...
Cached Medicine Technology:China Kanghui Holdings to Report Second Quarter 2011 Financial Results on August 16, 2011 2Soligenix Announces Expansion of Partnership With Sigma-Tau Pharmaceuticals for orBec® in Europe 2Soligenix Announces Expansion of Partnership With Sigma-Tau Pharmaceuticals for orBec® in Europe 3Soligenix Announces Expansion of Partnership With Sigma-Tau Pharmaceuticals for orBec® in Europe 4Soligenix Announces Expansion of Partnership With Sigma-Tau Pharmaceuticals for orBec® in Europe 5Soligenix Announces Expansion of Partnership With Sigma-Tau Pharmaceuticals for orBec® in Europe 6Soligenix Announces Expansion of Partnership With Sigma-Tau Pharmaceuticals for orBec® in Europe 7Soligenix Announces Expansion of Partnership With Sigma-Tau Pharmaceuticals for orBec® in Europe 8
Ideal for nucleus manipulation during phacoemulsification. Also used for manipulating and rotating IOLs within the anterior chamber. Round knurled handle...
Short, narrow paddle angled 45 degree inserts through the side port stab incision and is ideal for effective manipulation of the lens during anterior chamber phacoemulsification....
Nucleus divider with 1.25 mm tip and blade offset at a 60 degree angle is ideal for performing the "Phaco Chop" technique. Round knurled handle. Manufactured in titanium....
#2 10 mm hook. Flat serrated handle with polished finish. Overall length: 5.5 inches....
Medicine Products: