Navigation Links
Method makes it easier to separate useful stem cells from 'problem' ones for therapies
Date:4/22/2013

Pluripotent stem cells can turn, or differentiate, into any cell type in the body, such as nerve, muscle or bone, but inevitably some of these stem cells fail to differentiate and end up mixed in with their newly differentiated daughter cells.

Because these remaining pluripotent stem cells can subsequently develop into unintended cell types bone cells among blood, for instance or form tumors known as teratomas, identifying and separating them from their differentiated progeny is of utmost importance in keeping stem cellbased therapeutics safe.

Now, UCLA scientists have discovered a new agent that may be useful in strategies to remove these cells. Their research was published online April 15 in the journal Developmental Cell and will appear in an upcoming print edition of the journal.

The study was led by Carla Koehler, a professor of chemistry and biochemistry at UCLA, and Dr. Michael Teitell, a UCLA professor of pathology and pediatrics. Both are members of the Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at UCLA and UCLA's Jonsson Comprehensive Cancer Center.

In work using the single-celled microorganism known as baker's yeast, or Saccharomyces cerevisiae, as a model system, Koehler, Teitell and their colleagues had discovered a molecule called MitoBloCK-6, which inhibits the assembly of cells' mitochondria the energy-producing "power plants" that drive most cell functions. The research team then tested the molecule in a more complex model organism, the zebrafish, and demonstrated that MitoBloCK-6 blocked cardiac development.

However, when the scientists introduced MitoBloCK-6 to differentiated cell lines, which are typically cultured in the lab, they found that the molecule had no effect at all. UCLA postdoctoral fellow Deepa Dabir tested the compound on many differentiated lines, but the results were always the same: The cells remained healthy.

'/>"/>
Contact: Shaun Mason
smason@mednet.ucla.edu
310-206-2805
University of California - Los Angeles
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. New Method May Help Pinpoint Womans Final Menstrual Period
2. Arlington, VA Cosmetic Dentist, Dr. Duke Kim Now Offers Modern Alternatives to Traditional Braces with the Invisalign and Six Month Smiles Teeth Straightening Methods
3. New method developed to expand blood stem cells for bone marrow transplant
4. Researchers new method may sharpen microscopic images
5. Non-Animal Testing Alternatives are on the Rise; Bovine Corneal Opacity and Permeability (BCOP) Test and Mattek Test Methods are Gaining Popularity.
6. hCGTreatments / Diet Doc hCG Diets and Weight Loss Plans Reveals Their Most Effective Method to Rapidly Lose Weight with 100% Pure Prescription hCG
7. New Method Quickly Spots Kidney Damage After Surgery
8. AOM North America Announces Proven Methodology Designed to Help Customers Unleash the Power of People
9. CycleBeads Natural Birth Control Method Ranks High in Perfect Use and Typical Use Efficacy According to Most Recent Review of Global Family Planning Reports
10. Jersey Shore Rescue Mission and United Methodist Homes Partner to Serve Hot Evening Meals
11. New methodology to predict pandemics
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... 2015 Deer Path of Huntley -- ... Day Happy Hour from 3 p.m. to 4 p.m. on Feb. ... in Huntley, Illinois, serves adults with physical disabilities between the ages ... Valentine's Day treats, games and sweetheart-themed karaoke. , For more information ...
(Date:1/22/2015)... 22, 2015 Woodloch Pines, an all-inclusive ... selected by TripAdvisor as the number one best large hotel ... in the world for their annual Travelers’ Choice Awards. ... . The website is home to millions of unbiased and ...
(Date:1/22/2015)... Angelweddingdress is a famous wedding dress company offering many trendy ... on Facebook, Twitter, and Pinterest. The fans will have an ... lottery every week. , Moreover, the company has extended its ... Angelweddingdress homepage for more information. , Angelweddingdress is ...
(Date:1/22/2015)... (PRWEB) January 22, 2015 A new ... of experience and person-centeredness in the long-term care environment ... action across the continuum. The paper, “The Power of ... engages perspectives and practices of the patient, resident and ...
(Date:1/22/2015)... NJ (PRWEB) January 22, 2015 Joan ... and keynote speaker at the upcoming 32nd Annual ... ACCME-accredited Physicians’ Education Resource®, LLC (PER®) , shares ... would have gone undetected if she had not followed ...
Breaking Medicine News(10 mins):Health News:Deer Path of Huntley Affordable Assisted Living to Host Valentine's Day Happy Hour 2Health News:TripAdvisor Names Woodloch Pines Best Hotel for Families in America 2Health News:TripAdvisor Names Woodloch Pines Best Hotel for Families in America 3Health News:Angelweddingdress Invites Its Customers To Follow It On Facebook, Twitter, And Pinterest 2Health News:The Power of Person-Centeredness in Long-Term Care Explored by The Beryl Institute 2Health News:The Power of Person-Centeredness in Long-Term Care Explored by The Beryl Institute 3Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 2Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 3Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 4Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 5Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 6
... (Nasdaq: BFRM ) announced that on Thursday, December ... quarter fiscal year 2008 financial,results. The Company will issue ... and will hold a conference call with investors at ... Chief Executive Officer Steve Basta and Chief Financial Officer,Derek ...
... Activists Awarded Three-Year $5.2,Million Grant, SAN FRANCISCO, ... of the International Treatment Preparedness Coalition,and Tides, announced ... for $5.2,million from the Bill & Melinda Gates ... in advocacy and educational,activities to increase access to ...
... Tenn., Dec. 5 National partners,from the 16th ... presented more than $1.7 million of the projected ... in the fight against,childhood cancer. Companies represented at ... Wild Wings, Casey,s General Store, Fox,& Hound, Hess ...
... Donates "Asthma & Allergy Friendly" Toys to Kids ... Dec. 5 The oldest and largest,allergy patient ... Allergy,Foundation of America (AAFA), made the holidays a ... to asthma, allergies or,other respiratory diseases by donating ...
... believe,in themselves can raise their aspirations, motivation and accomplishments,and ... others do them., So says Albert Bandura, a ... won the 2008 University of Louisville,Grawemeyer Award for Psychology. ... among 31 nominations from five countries., Bandura,s ideas ...
... MYL ),today announced that Matrix Laboratories Limited* ... Drug Administration (FDA) under the,President,s Emergency Plan for ... (ANDA) for Tenofovir Disoproxil Fumarate Tablets, 300 mg.,Matrix,s ... generic,tentative approval of Gilead Sciences Inc.,s Viread Tablets, ...
Cached Medicine News:Health News:BioForm to Announce First Quarter Fiscal 2008 Financial Results and Host Conference Call and Webcast on December 13, 2007 2Health News:HIV Collaborative Fund Receives Gates Foundation Grant for AIDS Treatment and Prevention Advocacy 2Health News:HIV Collaborative Fund Receives Gates Foundation Grant for AIDS Treatment and Prevention Advocacy 3Health News:National Partners from St. Jude Halloween Promotion Presents More Than $1.7 Million to Help Fight Childhood Cancer 2Health News:Allergy Foundation Thinks Globally, Gifts Locally 2Health News:Self-Confidence Can Make Us Better, Says Grawemeyer Psychology Winner 2Health News:Mylan Announces Tentative FDA Approval Under PEPFAR for Tenofovir Disoproxil Fumarate Tablets 2
(Date:1/22/2015)... Inc. (NASDAQ: UPI ), a medical device company ... treat voiding dysfunctions, today reported financial results for the ... Global revenue for the Company,s Urgent ®  PC Neuromodulation ... revenue record, as compared to $3.9 million in the ...
(Date:1/22/2015)... Calif. , Jan. 22, 2015  Amgen (NASDAQ: AMGN ... full year 2014 financial results on Tuesday, Jan. 27, 2015, after ... followed by a conference call with the investment community at 2 ... Robert A. Bradway , chairman and chief executive officer, and other ...
(Date:1/22/2015)... PARK, Calif. , Jan. 22, 2015 Increasing ... the continued consolidation of localization purchasing in 2015, says ... According to a recent study by market research ... chose a single-source solution for their translation and localization ...
Breaking Medicine Technology:Uroplasty Reports Record Revenue in Fiscal Third Quarter 2Uroplasty Reports Record Revenue in Fiscal Third Quarter 3Uroplasty Reports Record Revenue in Fiscal Third Quarter 4Uroplasty Reports Record Revenue in Fiscal Third Quarter 5Uroplasty Reports Record Revenue in Fiscal Third Quarter 6Uroplasty Reports Record Revenue in Fiscal Third Quarter 7Uroplasty Reports Record Revenue in Fiscal Third Quarter 8Uroplasty Reports Record Revenue in Fiscal Third Quarter 9Uroplasty Reports Record Revenue in Fiscal Third Quarter 10Uroplasty Reports Record Revenue in Fiscal Third Quarter 11Uroplasty Reports Record Revenue in Fiscal Third Quarter 12Uroplasty Reports Record Revenue in Fiscal Third Quarter 13Uroplasty Reports Record Revenue in Fiscal Third Quarter 14Uroplasty Reports Record Revenue in Fiscal Third Quarter 15Uroplasty Reports Record Revenue in Fiscal Third Quarter 16Uroplasty Reports Record Revenue in Fiscal Third Quarter 17Uroplasty Reports Record Revenue in Fiscal Third Quarter 18Amgen Announces Webcast of 2014 Fourth Quarter and Full Year Financial Results 2Moravia Sees Single-Sourcing as Key Localization Trend in 2015 2
Inquire...
EPS 3501 : 3500 V, 150 mA, 100 W maximum. Constant voltage, constant current, or constant power modes. Stores and recalls three protocols. Excellent for manual DNA sequencing and IEF applications....
... The digital 200 V/2000 mA PSE Power ... 1 volt and 10 mA increments. • It ... 2000® apparatus simultaneously at 55°C. Features: Direct ... voltage, current and time • Voltage, mA and ...
... PowerPac Universal power supply, 100-120 and 220-240 ... A, and 1-500 W. The two-line, 16-character ... and monitoring of run progress. Built-in infrared ... unit contains a built-in switch when using ...
Medicine Products: