Navigation Links
Metformin improves blood glucose levels and BMI in very obese children
Date:12/10/2012

Chevy Chase, MD Metformin therapy has a beneficial treatment effect over placebo in improving body mass index (BMI) and fasting glucose levels in obese children, according to a recent study accepted for publication in The Endocrine Society's Journal of Clinical Endocrinology & Metabolism (JCEM). The study showed reduction in BMI was sustained for six months.

Childhood obesity has increased globally over the last two decades and it is linked to an increase in the diagnosis of type 2 diabetes in childhood, previously a condition that was only diagnosed in adults. Metformin is a first line drug for type 2 diabetes, and has been used for many decades. In adults metformin delays the onset of type 2 diabetes, but there is no evidence that the drug has a similar effect on children.

"Our findings provide evidence that a treatment course of metformin is clinically useful, safe and well-tolerated in obese children who are at risk for type 2 diabetes," said Deborah Kendall, MD, of Royal Manchester Children's Hospital in the United Kingdom and lead author of the study. "Metformin may also provide stimulus for lifestyle changes and potentially reduce long-term risk for type 2 diabetes and its associated health problems."

This prospective, randomized, double-blind, placebo-controlled trial was conducted at six pediatric endocrine centers in the United Kingdom and involved 151 obese children and young people with hyperinsulinemia and/or impaired fasting glucose or impaired glucose tolerance. Study participants received either metformin or placebo daily for six months. This trial is the largest of its kind to focus on metformin in obese non-diabetic children and young people.

"Our results show that metformin can improve BMI and blood glucose levels in obese children, but longer term effects such as reduction in the incidence of type 2 diabetes need further study," noted Kendall.


'/>"/>

Contact: Aaron Lohr
alohr@endo-society.org
240-482-1380
The Endocrine Society
Source:Eurekalert

Page: 1

Related medicine news :

1. Study: Metformin offers cardio benefits over sulfonylureas in diabetes
2. Metformin may lower cancer risk in people with Type 2 diabetes
3. Metformin Outperforms Common Class of Diabetes Drugs in Study
4. Value of Metformin, Insulin Combo for Type 2 Diabetes Questioned
5. New Treatment Aids Weight Loss, Improves Diabetes in Monkeys
6. Networks it takes a village approach improves dementia care and informs research, study shows
7. 1 week at a health spa improves your health, study shows
8. First-of-its-kind program improves outcomes for seniors admitted for trauma
9. California improves its ranking on March of Dimes Annual Preterm Birth Report Card
10. Smart drug improves survival in older patients with acute myeloid leukemia
11. Cambridge software improves quality of sound for hearing aid users
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/7/2016)... (PRWEB) , ... December 07, 2016 , ... ... (NYLF): Medicine will have the unique opportunity to get hands-on experience in ... high school students an immersive experience to gain invaluable, real-life medical skills that ...
(Date:12/7/2016)... ... December 07, 2016 , ... Children exposed to secondhand ... at the Icahn School of Medicine at Mount Sinai has found. The study ... young children are exposed to secondhand marijuana smoke, measurable amounts of primary metabolite ...
(Date:12/7/2016)... ... December 07, 2016 , ... OC87 Recovery Diaries (oc87recoverydiaries.com) recounts ... in a unique, personal perspective through animation. , That woman is Sheri ... at her private psychotherapy practice. Sheri’s mother, Pearl, lived with schizophrenia. , ...
(Date:12/7/2016)... , ... December 07, 2016 , ... It is vital ... is with useful, properly analyzed data. The team at Beckman Coulter has designed Kaluza, ... 'need for speed' and the need to operate in a GLP (Good Laboratory Practice) ...
(Date:12/7/2016)... ... 07, 2016 , ... Levels of a protein in the blood associated with ... online in the journal Radiology. , Heart disease and brain disease exact a major ... rapidly aging population. Damage to both organs often occurs at a subclinical stage, or ...
Breaking Medicine News(10 mins):
(Date:12/8/2016)... N.J., Dec. 8, 2016 CANTEL MEDICAL CORP. (NYSE: ... of $18,800,000, or $0.45 per diluted share, on a 22.1% ... quarter ended October 31, 2016. This compares with net income ... $153,779,000 for the first quarter ended October 31, 2015. ... quarter ended October 31, 2016 to $21,323,000, or $0.51 per ...
(Date:12/8/2016)... SAN DIEGO , Dec. 8, 2016 /PRNewswire/ ... with cutting edge next-generation sequencing and bioinformatics expertise; AITbiotech Pte ... the Genome Institute of Singapore (GIS) ... joint venture between Novogene and AITbiotech – will establish a ... Singapore .   The new centre will ...
(Date:12/7/2016)... Dec. 7, 2016   IQuity, Inc., a ... Don Hardison has been appointed to ... executive with extensive experience as CEO, COO, and ... 500 companies within the molecular, clinical diagnostic, and ... and sales experience within the pharmaceutical industry. His ...
Breaking Medicine Technology: