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Metformin's Anti-Cancer Properties Clarified in an Obesity Cell Model of Pancreatic Cancer
Date:7/22/2013

rticle, online first, in the journal Metabolomics and is titled, “Contextual inhibition of fatty acid synthesis by metformin involves glucose-derived acetyl-CoA and cholesterol in pancreatic tumor cells.” http://link.springer.com/article/10.1007%2Fs11306-013-0555-4

The study was supported by the Hirshberg Foundation for Pancreatic Cancer Research (http://www.pancreatic.org). “It is a key goal of the Foundation to bring lead scientists together to shed light on well-known, yet unexplained disease controlling mechanism of national research interest in obesity, diabetes and pancreatic cancer. This research is significant because it is in line with the National Cancer Institute’s quest to find bold new approaches to answer the perplexing scientific question of why the mechanism of a drug like metformin, which is generally used for other indications, protects against cancer incidence and mortality,“ said Agi Hirshberg, President of the Foundation.

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SiDMAP provides flux-based, metabolic profiling services to pharmaceutical, biotech and research organizations seeking to enhance their drug development processes, and develop further insights into a drug’s mechanism of action and disease states. SiDMAP’s unique tracer technology measures metabolic pathway flux to gain unique insights into cell function. A SiDMAP assay provides clients with an accurate, dynamic metabolic analysis of a compound’s biological impact in both in vitro and in vivo systems, before a company spends millions more on development and clinical trials. SiDMAP is headquartered in Los Angeles, California.

Read the full story at http://www.prweb.com/releases/2013/7/prweb10947481.htm.


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